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Nutritive preparation containing butyric acid

A technology of nutritional preparations and enteral nutritional preparations, applied in the functions of dairy products, milk preparations, food ingredients, etc. Reduced duration, less severe effects

Inactive Publication Date: 2018-02-27
SHANGHAI INST OF PEDIATRIC RES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent is used to improve gastrointestinal function by adding several nutritional ingredients, and there is no evidence to prove the effect of this formula in the prevention and treatment of necrotizing enterocolitis
And butyric acid is a weak acid, volatile and smelly
The patent adds butyric acid directly to the enteral nutrition formula, which will not only bring in an unpleasant smell, but more importantly, weak acid substances may not have much impact on the normal and mature intestinal tract, but directly adding weak acid Substances that stimulate the immature gut in newborn individuals, especially those at risk for necrotizing enterocolitis, may accelerate gut damage
[0007] Since necrotizing enterocolitis mainly occurs in infants and young children, the safety of the prevention and treatment method is the first and most important consideration, and if the traditional medicine is used for intervention, it may cause certain side effects, especially for preventive purposes, it is difficult to obtain these years Approval by parents or medical personnel of infants

Method used

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  • Nutritive preparation containing butyric acid
  • Nutritive preparation containing butyric acid
  • Nutritive preparation containing butyric acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] This example provides a nutritional preparation containing sodium butyrate and a preparation method thereof. The method is as follows: adding food-grade or injection-grade sodium butyrate into the nutritional preparation, mixing evenly, and obtaining the product. The concentration of sodium butyrate in the prepared nutritional preparation is 1-100mM.

Embodiment 2

[0075] This example provides a nutritional preparation containing sodium butyrate and a preparation method thereof. The method is as follows: adding food-grade or injection-grade sodium butyrate into the nutritional preparation, mixing evenly, and obtaining the product. The concentration of sodium butyrate in the prepared nutritional preparation is 100-200mM.

Embodiment 3

[0077] This example provides a nutritional preparation containing glyceryl butyrate and a preparation method thereof. The method is as follows: adding glyceryl butyrate of food grade or injection grade into the nutritional preparation, mixing evenly, and obtaining the product. The concentration of butyrin in the prepared nutritional preparation is 0.5-100mM.

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Abstract

The invention provides a nutritive preparation containing butyric acid. The nutritive preparation comprises a nutrient composition and a butyric acid compound, wherein the concentration of the butyricacid compound in the nutritive preparation is 0.5-200mM(mmol / L); and the butyric acid compound is selected from at least one of butyric acid, butyrate and butyric acid derivatives. The butyric acid compound is added to the nutrient composition, so that necrotizing enterocolitis can be prevented and treated, and besides, the nutritive preparation has the effects of promoting growth, and promotingdevelopment of the immune system and maturation of intestinal tracts.

Description

technical field [0001] The invention relates to the field of food technology, in particular to a nutritional preparation containing butyric acid, specifically including a nutritional preparation containing at least one of butyric acid, butyrate and butyric acid derivatives, which can be used to prevent and treat necrotic small intestine and colon inflammation. Background technique [0002] Necrotizing enterocolitis (NEC) is a life-threatening intestinal disease in children and one of the important causes of neonatal death. Currently, there is no effective prevention and treatment method in clinical practice. With the advancement of perinatal medicine technology, the birth rate and survival rate of premature infants continue to increase, especially with the application of in vitro fertilization combined with embryo transfer technology, the incidence of NEC has shown an increasing trend in recent years. The long-term outcome of children with NEC is unsatisfactory, and the mor...

Claims

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Application Information

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IPC IPC(8): A23L33/10A23C9/152
CPCA23C9/152A23L33/10A23V2002/00A23V2200/32
Inventor 文洁蔡威
Owner SHANGHAI INST OF PEDIATRIC RES
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