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A kind of Shengmai granule and preparation method thereof

A granule and Shengmai technology, applied in the field of Shengmai granules and their preparation, can solve the problems of low extraction rate and transfer rate, poor solubility of extract, low bioavailability, etc., saving raw materials and working time, and shortening preparation time. , the effect of low labor intensity

Active Publication Date: 2021-03-16
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Based on the prescription of Shengmaisan, the pharmaceutical forms of Shengmai that have been developed include Shengmai injection, Shengmaiyin oral liquid, Shengmai capsule, Shengmai granule, etc. The existing dosage forms and formulas have some defects in use gradually. Exposure, such as low stability, short storage period, low bioavailability, large dosage, etc., these problems need to be effectively resolved
[0006] In addition, at present, there are many problems in the preparation process of Shengmai Granules on the market, such as complex process, long time consumption, large amount of solvent, low extraction rate and transfer rate, poor solubility of extract, poor taste, etc.

Method used

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  • A kind of Shengmai granule and preparation method thereof
  • A kind of Shengmai granule and preparation method thereof
  • A kind of Shengmai granule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Dangshen 300g Ophiopogon japonicus 200g Schisandra 100g

[0033] Sucrose 500g Dextrin 15g

[0034] (1) Schisandra chinensis, Codonopsis pilosula, and Ophiopogon japonicus are pulverized respectively, and the number of sieves is 20 mesh;

[0035] (2) get Schisandra chinensis and soak 12 hours in 65% ethanol aqueous solution with volume percentage concentration, heat and reflux for 3 hours, collect volatile oil, and extract for subsequent use; then add volume percentage concentration again and be 65% ethanol aqueous solution and heat and reflux for 2 hours, collect extract, Combine two extracts to obtain Schisandra extract;

[0036] (3) Take Codonopsis pilosula and Radix Ophiopogon japonicus at 95° C. and perform dynamic extraction with water 10 times the weight of the medicinal materials. The rotational speed is controlled at 55 rpm, and the extract is obtained after 2 hours;

[0037] (4) After the Schisandra extract prepared in step (2) and the Ophiopogon japonicus ex...

Embodiment 2

[0041] Codonopsis 250g Ophiopogon japonicus 200g Schisandra 80g

[0042] Sucrose 450g Dextrin 12g

[0043] (1) Schisandra chinensis, Codonopsis pilosula and Ophiopogon japonicus are pulverized respectively, and the number of sieves is 30 mesh;

[0044] (2) Get Schisandra chinensis and soak it in 50% ethanol aqueous solution for 24 hours, heat and reflux for 5 hours, collect volatile oil, and extract for subsequent use; then add 50% ethanol aqueous solution for 4 hours and collect the extract, Combine two extracts to obtain Schisandra extract;

[0045] (3) Take Codonopsis pilosula and Radix Ophiopogon japonicus at 95°C, and perform dynamic extraction with water 11 times the weight of the medicinal materials, and control the rotation speed at 50 rpm, and obtain the extract after 3 hours;

[0046] (4) After the Schisandra extract prepared in step (2) and the Ophiopogon japonicus extract prepared in step (3) are combined, they are filtered, ultracentrifuged and concentrated unde...

Embodiment 3

[0050] Dangshen 250g Ophiopogon japonicus 250g Schisandra 60g

[0051] Sucrose 400g Dextrin 13g

[0052] (1) Schisandra chinensis, Codonopsis pilosula, and Ophiopogon japonicus are crushed separately, and the number of sieves is 10 mesh;

[0053] (2) get Schisandra chinensis and soak 15 hours in 70% ethanol aqueous solution with volume percentage concentration, heat and reflux for 3 hours, collect volatile oil, extract for subsequent use; then add volume percentage concentration again and be that 65% ethanol aqueous solution heat and reflux for 3 hours, collect extract, Combine two extracts to obtain Schisandra extract;

[0054] (3) Take Codonopsis pilosula and Radix Ophiopogon japonicus at 90°C and perform dynamic extraction with water 9 times the weight of the medicinal materials, and control the rotation speed at 60 rpm, and obtain the extract after 2 hours;

[0055] (4) After the Schisandra extract prepared in step (2) and the Ophiopogon japonicus extract prepared in ste...

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Abstract

The invention discloses a pulse-activating particle and a preparation method thereof. Fructus schisandrae is extracted through an ethanol aqueous solution; after volatile oil is collected, the contentis obviously increased; radix codonopsis and radix ophiopogonis are dynamically extracted, so that raw materials and working time are greatly saved; the effective concentrations of extracting solutions are improved; the spray granulation is carried out by adopting a fluidized bed; the volatile oil is firstly sprayed; afterwards, and a radix codonopsis concentrated solution is sprayed, so that thestability of a medicine is obviously improved. The preparation method provided by the invention has the advantages of simpleness, high bioavailability, short production cycle, low cost and suitability for industrialized production and does not need any special equipment.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a Shengmai granule and a preparation method thereof. Background technique [0002] Shengmai granules are derived from the ancient prescription Shengmaisan, which is a famous ancient prescription for nourishing qi and nourishing yin in traditional Chinese medicine. The prescription is composed of three medicines: ginseng, Ophiopogon japonicus, and Schisandra chinensis. Ginseng is sweet in nature and can nourish the middle and Qi, nourish the lungs and promote body fluid; Ophiopogon japonicus is sweet in nature, slightly bitter, and slightly cold, which can nourish yin and benefit the stomach, moisten the lungs and clear the heart. , so it is a good medicine for nourishing yin and nourishing yin; schisandra, sour and warm, has the effects of solidifying the surface and astringing sweat, astringing the lungs, nourishing the kidney and strengthening essence, p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8968A61K9/16A61P39/00A61P1/14
CPCA61K9/1652A61K36/344A61K36/57A61K36/79A61K36/8968A61K2236/331A61K2236/333A61K2236/39A61K2236/53A61K2300/00
Inventor 刘景萍刘全国陈克领林文君王家李党
Owner HAINAN HULUWA PHARMA GRP CO LTD
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