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A Class of Near Infrared Fluorescent Small Molecule Probes

A small-molecule probe and near-infrared technology, applied in the field of near-infrared imaging, can solve the problems of complex operation, lack of targeting specificity, and high cost

Active Publication Date: 2020-01-10
阿克索南京生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the current MS diagnosis technology, it mainly relies on magnetic resonance imaging technology, which does not have target specificity, and has the disadvantages of complicated operation and high cost.

Method used

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  • A Class of Near Infrared Fluorescent Small Molecule Probes
  • A Class of Near Infrared Fluorescent Small Molecule Probes
  • A Class of Near Infrared Fluorescent Small Molecule Probes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0010] A class of near-infrared fluorescent small molecule probes, the structure of which is as follows:

[0011]

[0012] Among them, R 1 , R 2 Represents hydrogen, an alkyl group with five carbons (including five), -NH-R 2 The substituent can be located at the 1-position, 2-position, 3-position or 4-position of the benzene ring; it is characterized in that the emission wavelength is greater than 650nm and falls into the near-infrared region.

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Abstract

The invention relates to the field of near-infrared imaging and particularly relates to a near-infrared fluorescent small molecule probe and its application in the field of myelin sheath imaging. Thesmall molecule probe is shown in the description. A fluorescence performance test result shows that the emission wavelength is greater than 650 nm in the near infrared region. The small molecule probecan be effectively bonded to the myelin sheath part, significantly enhance the imaging effect of the myelin sheath part, can be used for myelin sheath imaging under near-infrared conditions and provides a novel method for diagnosis and effect evaluation of central nervous system diseases such as multiple sclerosis.

Description

technical field [0001] The invention relates to the field of near-infrared imaging, in particular to a type of near-infrared fluorescent small molecule probe and its application in the field of myelin imaging. Background technique [0002] Fluorescence imaging technology has been widely used in many fields such as tumor diagnosis, biomolecular detection, drug distribution and metabolism due to its advantages of non-invasiveness, visualization, high spatial and temporal resolution, low cost, safety and speed. Some components of organisms (such as melanin, hemoglobin, cytochrome, etc.) have higher absorption or scattering of visible light bands, which will lead to poor tissue penetration of visible light, and biological tissues in this band have certain autofluorescence interference. In contrast, blood and human tissue have low absorption and scattering of 650-900nm near infrared (NIR) light, so near infrared fluorescence can easily pass through biological tissue for in vivo ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D265/34C09K11/06G01N21/64A61K49/00
CPCA61K49/0028C07D265/34C09K11/06C09K2211/1033G01N21/6486
Inventor 孙宏顺李玉龙蒋蕻许宁陆新华陈玉良
Owner 阿克索南京生物科技有限公司
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