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Preparation of sugarcane leaf polysaccharide and its application to treat and prevent diabetes

A sugarcane leaf, diabetes technology, applied in the field of diabetes treatment, can solve problems such as not being able to truly simulate diabetes

Inactive Publication Date: 2018-03-09
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Chemically induced diabetes models are widely used in diabetes research due to their high success rate and simple methods, but chemically induced diabetes models cannot really simulate the mechanism of diabetes in the body

Method used

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  • Preparation of sugarcane leaf polysaccharide and its application to treat and prevent diabetes
  • Preparation of sugarcane leaf polysaccharide and its application to treat and prevent diabetes
  • Preparation of sugarcane leaf polysaccharide and its application to treat and prevent diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] Preventive effect and mechanism of sugarcane leaf polysaccharide on diabetes in NOD mice

[0016] 1 Experimental instruments and materials

[0017] 1.1 Experimental Instruments

[0018] High-speed refrigerated centrifuge, model: X1R, Thermo Scientific, USA; -20°C refrigerator, model: BC-45M, Guangdong Midea Group Co., Ltd.; CO 2 Constant temperature incubator, model: MCO-18AIC, Japan SANYO company; full-wavelength microplate reader, model: Epoch, American BioTek Co., Ltd.; electronic scale, model: JCS-300, Zhejiang Kaifeng Group Co., Ltd.; Roche excellent blood glucose meter And blood glucose test strips, Germany Roche Co., Ltd.

[0019] 1.2 Experimental reagents

[0020] FTY720, TCI (Shanghai) Chemical Industry Development Co., Ltd., lot number F1018; mouse insulin Elisa kit, lot number 15019657, mouse IL-2 Elisa kit, lot number 01019659, mouse TNF-alpha Elisa kit, lot number 03019658, Mouse IL-17 Elisa kit, batch number 03019660, Wuhan Huamei Technology Co., Ltd.;...

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Abstract

The invention discloses a preparation method of sugarcane leaf polysaccharide and its application to treat and prevent diabetes. An inventor extracts and acquires sugarcane leaf polysaccharide from sugarcane leaves; the inventor carries out deep study by adopting non-obese diabetic mice, and finds that the sugarcane leaf polysaccharide has preventive effect to the mice diabetes of the non-obese diabetic mice. The experiment result shows that there are 8 mice with diabetes from 12 NOD mice of a model group, wherein the morbidity is 66.7%; there are 3 mice with diabetes from 12 NOD mice of a sugarcane leaf polysaccharide group, the morbidity is 25%; the morbidity is obviously reduced (P is less than 0.05); the mechanism may be related to the sugarcane leaf polysaccharide ability of improvinginflammatory reaction in the NOD mice body and enhancing the oxidization resistance in the NOD mice body. Hereby, the sugarcane leaf polysaccharide has a certain application prospect in treating andpreventing diabetes, in particular to I-type diabetes.

Description

technical field [0001] The invention belongs to the field of diabetes treatment, in particular to the preparation of sugarcane leaf polysaccharide and its application in treating and preventing diabetes. Background technique [0002] Chemically induced diabetes models are widely used in diabetes research because of their high success rate and simple methods, but chemically induced diabetes models cannot truly simulate the mechanism of diabetes in vivo. Spontaneous diabetes animal models are animal models that are produced naturally under natural conditions, or appear similar to human diabetes due to gene mutations. This model is closer to the natural onset and development of human diabetes. [0003] Non-obese diabetic mice (Non-obese diabetic, NOD) are inbred from ICR / Jcl mice, which can spontaneously develop insulin-dependent diabetes, that is, type 1 diabetes. Its pathogenesis is similar to the pathogenesis of human type 1 diabetes. Insulitis occurs in the early stage of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K31/715A61P3/10
CPCA61K31/715C08B37/0003
Inventor 侯小涛邓家刚郝二伟杜正彩何耀涛
Owner GUANGXI UNIV OF CHINESE MEDICINE
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