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Method and fermentation medium for fermentation production of nosiheptide

A fermentation medium and fermentation culture technology, applied in the field of fermentation, can solve the problems of unfavorable product marketization, low production level, high production cost, etc., and achieve the effects of easy popularization and application, reduction of raw material cost, and reduction of raw material cost.

Active Publication Date: 2018-04-03
牡丹江佰佳信生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limitation of production technology level, such as low production level of strains, viscous fermentation broth, large oxygen demand and other factors, the production cost is relatively high, which is not conducive to the marketization of this product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] A fermentation medium for fermentative production of nosiheptide, comprising the following components by weight: KNO 3 0.5 parts, (NH 4 ) 2 SO 4 0.8 parts, NaCl 3 parts, soybean powder 35 parts, soybean meal powder 1 part, corn starch 45 parts, amylase 0.01 part, light calcium carbonate 3.5 parts.

[0049] The fermentation medium of this example is a dry product medium, and its preparation method includes taking each raw material according to the formula, and mixing them uniformly according to a conventional method.

Embodiment 2

[0051] A fermentation medium for fermentative production of nosiheptide, comprising the following components by weight: KNO 3 1 part, (NH 4 ) 2 SO 4 1.5 parts, NaCl 5 parts, soybean powder 45 parts, soybean meal powder 2.5 parts, corn starch 56 parts, amylase 0.02 parts, light calcium carbonate 5 parts.

[0052] The fermentation medium of this example is a dry product medium, and its preparation method includes taking each raw material according to the formula, and mixing them uniformly according to a conventional method.

Embodiment 3

[0054] A fermentation medium for fermentative production of nosiheptide, comprising the following components by weight: KNO 3 0.5 parts, (NH 4 ) 2 SO 4 1 part, 3.5 parts of NaCl, 38 parts of soybean flour, 1.5 parts of soybean meal powder, 50 parts of corn starch, 0.01 part of amylase, 4 parts of light calcium carbonate.

[0055] The fermentation medium of this example is a dry product medium, and its preparation method includes taking each raw material according to the formula, and mixing them uniformly according to a conventional method.

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Abstract

The invention belongs to the technical field of fermentation, and in particular relates to a method and a fermentation medium for fermentation production of nosiheptide. The fermentation medium is prepared from the following components in parts by weight: 0.5-1 part of KNO3, 0.8-1.5 parts of (NH4)2SO4, 3-5 parts of NaCl, 35-45 parts of soybean meal, 1-2.5 parts of soya bean meal, 45-56 parts of corn starch, 0.01-0.02 part of amylase, and 3.5-5 parts of light calcium carbonate. The fermentation medium provided by the invention has the advantages that the raw materials are low in cost and easilyavailable, and the cost of the raw materials can be reduced by about 23.6%. After the fermentation medium provided by the invention is used for fermentation production of nosiheptide, the content ofnosiheptide in the fermented liquid can be improved to 5630ug / mL, the effect is obviously superior to that of the prior art, and thus the method and the fermentation medium can be widely popularized and applied easily.

Description

technical field [0001] The invention belongs to the technical field of fermentation, and in particular relates to a method for producing nosiheptide by fermentation and a fermentation medium. Background technique [0002] Nosiheptide, also known as Nosiheptide, is a polypeptide antibiotic with 5 thiazole rings, and its molecular formula is C 51 h 43 N 13 o 12 S 6 , the relative molecular weight is 1222. Nosiheptide can be used as a feed additive and was approved by China as a three-category new veterinary drug in 1998. Nosiheptide is a macromolecular substance that is not absorbed in the body, so there is no residue. It has been widely used in the European Community, North America, Japan and other countries. use. As a feed additive, nosiheptide can improve feed utilization, low dosage, only antibacterial effect but no bactericidal effect, effective on Gram-positive bacteria, no cross-resistance with other antibiotics, no residue, safe to use, safe for animals and It h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P21/02C12N1/20C12R1/465
CPCC07K5/06139C12N1/20C12P21/02
Inventor 周贤龙石怀月刘静
Owner 牡丹江佰佳信生物科技有限公司
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