Preparation method and application of metallic phosphorescence complex

A technology of metal complexes and phosphorescence, applied in the direction of fluorescence/phosphorescence, indium organic compounds, platinum group organic compounds, etc., can solve the problem of inaccurate determination of oxygen content, etc., achieve reliable detection results and broad application prospects

Active Publication Date: 2018-04-06
NANJING UNIV OF POSTS & TELECOMM
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0006] In organisms, the oxygen content of different organelles is different, and it is not very accurate to judge the oxygen content by the luminescence intensity of the complex

Method used

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  • Preparation method and application of metallic phosphorescence complex
  • Preparation method and application of metallic phosphorescence complex
  • Preparation method and application of metallic phosphorescence complex

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Experimental program
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Effect test

Embodiment 1

[0032]

[0033] Synthesis of complex 1: Weigh NH 2 Add 1mmol of -C4 dichloro bridge and 2.2mmol of 4-methyl 4'-carboxy-2,2'-bipyridine into the reaction flask, vacuumize, under nitrogen protection, react at 40°C for 10h, then add KPF 6 30 mmol was reacted for 2 h, spin-dried, extracted with dichloromethane (3×150 mL), the organic phase was taken, spin-dried and loaded into a silica gel powder column, separated and purified, and the yield was 59%.

Embodiment 2

[0035]

[0036] Synthesis of complex 2: Weigh NH 2 Add 1mmol of -C8 dichloro bridge and 2.2mmol of 4-methyl 4'-carboxy-2,2'-bipyridine into the reaction flask, vacuumize, under nitrogen protection, react at 40°C for 10h, then add KPF 6 30 mmol was reacted for 2 h, spin-dried, extracted with dichloromethane (3×150 mL), the organic phase was taken, spin-dried and loaded into a silica gel powder column, separated and purified, and the yield was 64%.

Embodiment 3

[0038]

[0039] Synthesis of complex 3: Weigh NH 2 Add 1mmol of -C8 dichloro bridge and 2.2mmol of 4,4'-dicarboxy-2,2'-bipyridine into the reaction flask, vacuumize, under nitrogen protection, react at 40°C for 10h, then add KPF 6 30 mmol was reacted for 2 h, spin-dried, extracted with dichloromethane (3×150 mL), the organic phase was taken, spin-dried and loaded into a silica gel powder column, separated and purified, and the yield was 45%.

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Abstract

The invention belongs to the technical field of photoelectric functional organic materials and in particular relates to a preparation method and application of a metallic phosphorescence complex. Themetallic phosphorescence complex comprises a metal center and a cyclic metallic complex. The preparation method comprises the following step: performing a complexing reaction on N-N ligand and a C-N ligand with an amino chain, thereby obtaining the metallic phosphorescence complex. Through variations of service lives, the content of oxygen in organelle is relatively effectively judged, and different types of organelle can be well separated by using an FLIM (Fluorescence-Lifetime Imaging Microscopy) technique, so that the metallic phosphorescence complex has great significance for oxygen detection in cells, cytomembrane and mitochondria can be effectively separated by using the FILM technique, and the invention further discloses application of the metallic phosphorescence complex in fieldssuch as biological imaging, cell marking and oxygen detection.

Description

technical field [0001] The invention belongs to the technical field of photoelectric functional organic materials, and in particular relates to a preparation method and application of a phosphorescent metal complex. Background technique [0002] With the continuous development of cell biology, the resolution requirements of biological imaging technology for scientific research are also increasing. In recent years, many biological imaging technologies have been developed, and the research achievements in the field of cell imaging are remarkable. At present, the main biological imaging technologies cover two categories, namely, imaging diagnostic technology and optical imaging technology. Among them, imaging diagnostic technology includes ultrasonic imaging, X X-ray tomography, nuclear magnetic resonance imaging technology, etc., optical imaging technology includes chemiluminescence imaging technology, fluorescence microscopy imaging, etc. Optical imaging combined with lumine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F15/00C09K11/06G01N21/64
CPCC07F15/0033C09K11/06C09K2211/185G01N21/64G01N21/6486
Inventor 张寅位换杰张太伟赵强刘淑娟黄维
Owner NANJING UNIV OF POSTS & TELECOMM
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