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Extract, and preparation method and application thereof

A technology for extracts and strains, applied in the field of extracts and their preparation, can solve the problems of low physiological function, large dose-effect ratio, inconvenient use, etc., so as to improve gene expression and inhibit the production of β-galactosidase. Effect

Active Publication Date: 2018-04-10
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The study found that there are the following problems that need to be solved urgently in the effect of Chinese medicinal materials on delaying aging. 1. Chinese medicinal materials with significant effects often have the problem of scarcity of resources; The dose-effect ratio is too large, and it is inconvenient to use

Method used

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  • Extract, and preparation method and application thereof
  • Extract, and preparation method and application thereof
  • Extract, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] 1. Liquid fermentation culture

[0059] Liquid culture medium: take 1kg of potatoes, add 5kg of water, boil the juice, add 20wt% glucose, 5wt% peptone, and 1wt% potassium dihydrogen phosphate to the juice, sterilize at 126°C for 30 minutes, and cool to get the product;

[0060] Liquid fermentation culture: inoculate 2% of the above-mentioned strain 1 on the above-mentioned liquid medium, and ferment at 29°C to 35°C for 5 days to obtain liquid strains of Ganoderma lucidum;

[0061] 2. Solid-state fermentation culture

[0062] Take 100g of safflower and 900g of salvia miltiorrhiza, crush them into 40-60 meshes, add 1.5-2.5 times the mass of water, after sterilization, inoculate 1% liquid strain of Ganoderma lucidum, and ferment for 5 days at 29°C-35°C , followed by high temperature inactivation;

[0063] 3. Extraction and preparation

[0064] Add 18 times the mass of 10% ethanol water solution, decoct for 3 hours at 40°C, take the extract, let it stand for 28 hours at ...

Embodiment 2

[0066] 1. Liquid fermentation culture

[0067] Liquid culture medium: take 1kg of potatoes, add 5kg of water, boil the juice, add 20wt% glucose, 5wt% peptone, and 1wt% potassium dihydrogen phosphate to the juice, sterilize at 126°C for 30 minutes, and cool to get the product;

[0068] Liquid fermentation culture: Inoculate 2% of the above-mentioned strain 2 on the above-mentioned liquid medium, and ferment and cultivate it at 10°C to 16°C for 15 days to obtain liquid strains of Ganoderma lucidum;

[0069] 2. Solid-state fermentation culture

[0070] Take 950g of safflower and 50g of salvia miltiorrhiza, crush them into 40-60 meshes, add 1.5-2.5 times the mass of water, after sterilization, inoculate 10% liquid strain of Ganoderma lucidum, and ferment for 18 days at 10°C-15°C , followed by high temperature inactivation;

[0071] 3. Extraction and preparation

[0072] Add 6 times the mass of water, decoct for 1 hour at a temperature of 95°C; take the extract, let it stand for...

Embodiment 3

[0074] 1. Liquid fermentation culture

[0075] Liquid culture medium: take 1kg of potatoes, add 5kg of water, boil the juice, add 20wt% glucose, 5wt% peptone, and 1wt% potassium dihydrogen phosphate to the juice, sterilize at 126°C for 30 minutes, and cool to get the product;

[0076] Liquid state fermentation culture: inoculate 2% of the above-mentioned strain 2 on the above-mentioned liquid medium, and ferment and cultivate it at 18°C-28°C for 8-10 days to obtain liquid strains of Ganoderma lucidum;

[0077] 2. Solid-state fermentation culture

[0078] Take 800g of safflower and 200g of Salvia miltiorrhiza, crush them into 25-35 meshes, add 1.5-2.5 times the mass of water, after sterilization, inoculate 5% liquid strain of Ganoderma lucidum, and ferment for 12 days at 22-29°C ; After high temperature inactivation;

[0079] 3. Extraction and preparation

[0080] Add 12 times the quality of water, and decoct for 2 hours at a temperature of 80°C; take the extract, let it sta...

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Abstract

The invention relates to the field of health care products, and in particular, relates to an extract, and a preparation method and an application thereof. Safflower and radix salviae miltiorrhizae arebiotransformed by ganoderma lucidum, an extract obtained by extracting an obtained fermentation product can inhibit the production of beta-galactosidase in aging fibroblasts, improves the gene expression of type-I collagen and type-III collagen in an aging process of the fibroblasts, and has the effect of resisting skin aging; the effects are proved significantly (p<0.05) to be better than thoseof conventional plant extracts or a combination thereof.

Description

technical field [0001] The invention relates to the technical field of health care products, in particular to an extract and its preparation method and application. Background technique [0002] In modern society, with the development of economic civilization, electronic devices such as mobile phones, computers, and televisions have become an integral part of human life and are indispensable. The radiation of these electronic devices is constantly accelerating the growth of human skin cells. Aging; at the same time, with the popularization and application of refrigeration equipment and the pollution of the environment, the ozone layer is severely damaged, resulting in the strengthening of the sun's radiation to the surface, which causes the aging problem of human skin to become increasingly serious. [0003] The aging phenomenon of skin mainly manifests in two aspects: 1. Skin tissue decline. The thickness of the skin changes significantly with age. The human epidermis is ...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/9728A61Q19/08
CPCA61K8/97A61K2800/782A61K2800/85A61Q19/08
Inventor 邓文娟杨琼利孙红梅车飙
Owner INFINITUS (CHINA) CO LTD
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