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Aifu soft capsule and its production method and application

A production method and a technology for soft capsules are applied in the field of pharmaceutical preparations and can solve the problems of large dosage and difficulty in storage.

Active Publication Date: 2021-03-26
河南省食品药品检验所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Aifu Nuangong Pills have the disadvantages of large dosage (the large dosage is related to the use of raw medicinal materials), not easy to store, etc.

Method used

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  • Aifu soft capsule and its production method and application
  • Aifu soft capsule and its production method and application
  • Aifu soft capsule and its production method and application

Examples

Experimental program
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Embodiment Construction

[0029] The technical solutions of the present invention will be further described in detail below in conjunction with the examples, but the protection scope of the present invention is not limited thereto.

[0030] 1. Instruments and materials

[0031] 1.1 Experimental equipment

[0032] YWJ100-II fully automatic soft capsule machine (Beijing Xinhangcheng Technology Development Co., Ltd.); Bright Medical Instrument Co., Ltd.); Volatile Oil Extractor (Nanjing Chemical Reagent Co., Ltd.); Electric Heating Mantle (Nanjing Kerr Instrument Experiment Co., Ltd.); Digital Display Constant Temperature Water Bath (Shanghai Jiangxing Instrument Co., Ltd.); (Shanghai Jinghong Instrument Equipment Co., Ltd.); JML-100 Colloid Mill (Zhengzhou Yuxiang Machinery Equipment Co., Ltd.); Homogenizer.

[0033] 1.2 Experimental materials

[0034] Prescription medicinal materials [Artemisia argyi (charcoal), Rhizoma Cyperi (made from vinegar), Evodia (made from), cinnamon, angelica, Chuanxiong, R...

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Abstract

The invention relates to a production method of a soft capsule with folium artemisiae argyi and rhizoma cyperi. The method comprises the following steps: (1) extracting volatile oil to obtain total volatile oil, filter residue (1) and filtrate (1); (1) extracting a water-soluble part to obtain filter residue (2) and filtrate (2), mixing the filtrate (1) with the filtrate (2), heating and concentrating under normal pressure, then drying in vacuum to obtain extract (1); (3) extracting an alcohol-soluble part, mixing the filter residue (1) with the filter residue (2), and treating to obtain extract (2), wherein the extract (1) and the extract (2) are extract powder; (4) uniformly mixing soybean oil, beewax, the extract powder and the total volatile oil to obtain soft capsule content; (5) heating and uniformly mixing glycerinum, water, ethylparaben and gelatin to obtain a soft capsule shell gelatin solution; and (6) adding the soft capsule content obtained in the step (4) and the soft capsule shell gelatin solution obtained in the step (5) into a soft capsule making machine, and preparing to obtain the soft capsule with folium artemisiae argyi and rhizoma cyperi. The soft capsule withfolium artemisiae argyi and rhizoma cyperi is low in administration dosage, rapid medicine releasing speed and high in stability, and can also be used as an anti-inflammatory drug.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to an Aifu soft capsule, a production method and application thereof. Background technique [0002] The prescription of Aifu Nuangong Wan is composed of 120g mugwort leaves (charcoal), 240g vinegar cyperus, 80g evodia rutaecarpa, 20g cinnamon, 120g angelica, 80g Chuanxiong, 80g white peony (wine fried), 40g rehmannia, 80g sunburned astragalus and 60g diapsis. Composed of ten medicines (see: National Pharmacopoeia Commission. Pharmacopoeia of the People's Republic of China (2015 Edition) Volume 1, China Medical Science and Technology Press, 2015.), has the effects of regulating qi and nourishing blood, warming the palace and regulating menstruation; used for blood deficiency and stagnation of qi , Irregular menstruation, dysmenorrhea, waist and knee pain caused by deficiency and cold in the lower Jiao. "Chinese Pharmacopoeia" stipulates the preparatio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/8905A61K47/44A61K47/42A61P29/00
CPCA61K9/4808A61K9/4825A61K9/4858A61K36/185A61K36/232A61K36/236A61K36/282A61K36/481A61K36/54A61K36/65A61K36/71A61K36/754A61K36/804A61K36/8905A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 王健杨海燕宋汉敏李振国张壮丽李海燕李逢春王莉张竞
Owner 河南省食品药品检验所