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Separation and purification of gallic acid from suaeda salsa by SF-SMB

A technology of simulated moving bed and gallic acid, which is applied in the field of separation and purification of gallic acid in Suaeda salsa using a supercritical simulated moving bed chromatography system, which can solve the problems of expensive supercritical fluid chromatography equipment, unsatisfactory purification effect, and low purity. Achieve the effect of continuous automatic operation, excellent mass transfer performance and high purity

Inactive Publication Date: 2018-04-13
BOHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Column chromatography mainly uses the principle of separation and purification based on the different adsorption capacities of different components of the fixed phase. The purification effect of this purification method is not ideal, and there are disadvantages such as low purity and poor efficiency.
High-performance liquid chromatography consumes a large amount of solvent products are too diluted and often cannot avoid the use of toxic solvents; supercritical fluid chromatography technology equipment is quite expensive, and the application of this technology in the laboratory is far greater than its application in industrial production

Method used

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  • Separation and purification of gallic acid from suaeda salsa by SF-SMB

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 1.1 Screening of Suaeda salsa

[0036] Choose Suaeda salsa with moderate size, fresh color and no pests;

[0037] 1.2 Pretreatment of Suaeda salsa

[0038] (1) Cleaning treatment

[0039] Soak the Suaeda salsa in clean water and rinse until there is no dirt on the Suaeda salsa;

[0040] (2) Drying treatment

[0041] Spread the Suaeda salsa flat and place it in a well-ventilated environment for drying treatment, and dry it in an oven at 60°C for 2 hours; make the moisture on the surface of Suaeda salsa dry;

[0042] (3) Finished

[0043] Carry out greening under microwave, spread the Suaeda salsa leaf thickness 3 centimeters, 2kw microwave treatment 10 minutes;

[0044] (4) Smash

[0045] Pulverize the Suaeda salsa treated in a pulverizer at room temperature and pass through a 60-mesh sieve;

[0046] 1.3 Extraction of gallic acid and quercetin

[0047] Suaeda salsa gallic acid was extracted by ultrasonic-assisted hydroenzyme method, treated with compound enzyme: ...

Embodiment 2

[0054] 1.1 Screening of Suaeda salsa

[0055] Choose Suaeda salsa with moderate size, fresh color and no pests;

[0056] 1.2 Pretreatment of Suaeda salsa

[0057] (1) Cleaning treatment

[0058] Soak the Suaeda salsa in clean water and rinse until there is no dirt on the Suaeda salsa;

[0059] (2) Drying treatment

[0060] Spread the Suaeda salsa flat and place it in a well-ventilated environment for drying treatment, and dry it in an oven at 60°C for 2 hours; make the moisture on the surface of Suaeda salsa dry;

[0061] (3) Finished

[0062] Carry out greening under microwave, spread the Suaeda salsa leaf thickness 3 centimetres, the microwave treatment of 2kw 10 minutes.

[0063] (4) Smash

[0064] Pulverize the Suaeda salsa treated in a pulverizer at room temperature and pass through a 60-mesh sieve;

[0065] 1.3 Extraction of gallic acid and quercetin

[0066] Suaeda salsa gallic acid was extracted by ultrasonic-assisted hydroenzyme method, treated with compound e...

Embodiment 3

[0073] 1.1 Screening of Suaeda salsa

[0074] Choose Suaeda salsa with moderate size, fresh color and no pests;

[0075] 1.2 Pretreatment of Suaeda salsa

[0076] (1) Cleaning treatment

[0077] Soak the Suaeda salsa in clean water and rinse until there is no dirt on the Suaeda salsa;

[0078] (2) Drying treatment

[0079] Spread the Suaeda salsa flat and place it in a well-ventilated environment for drying treatment, and dry it in an oven at 60°C for 2 hours; make the moisture on the surface of Suaeda salsa dry;

[0080] (3) Finished

[0081] Carry out greening under microwave, spread the Suaeda salsa leaf thickness 3 centimeters, 2kw microwave treatment 10 minutes;

[0082] (4) Smash

[0083] Pulverize the Suaeda salsa treated in a pulverizer at room temperature and pass through a 60-mesh sieve;

[0084] 1.3 Extraction of gallic acid and quercetin

[0085] Suaeda salsa gallic acid was extracted by ultrasonic-assisted hydroenzyme method, treated with compound enzyme: ...

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Abstract

The invention discloses separation and purification of gallic acid from suaeda salsa by SF-SMB, and relates to a method for separating and purifying the gallic acid from the suaeda salsa. In the wholeprocesses of extracting, separating and purifying the gallic acid from the suaeda salsa, water or ethanol which is environmentally-friendly to equipment and environments is taken as a solvent, and the solvent is conveniently recovered and the energy consumption is low; flavonoids constituents are not stable and easily oxidized, especially more susceptibly oxidized in high temperature environments, the separation and purification of the gallic acid from the suaeda salsa can be completed at room temperature by using an extraction method, the highest extraction temperature is controlled to be not higher than 70 DEG C, and conditions are relatively mild, thereby not affecting the extraction effect of flavonoids constituents, and further being beneficial to the stable existence of the flavonoids constituents; and by adopting the method of the invention, the continuity is enhanced, the purity of the gallic acid is high, the production cycle is shortened, and the cost is low.

Description

【Technical field】 [0001] The invention relates to a method for separating and purifying gallic acid in Suaeda salsa, in particular to a method for separating and purifying gallic acid in Suaeda salsa by using a supercritical simulated moving bed chromatography system. 【Background technique】 [0002] Gallic acid is also known as "gallic acid" and "gallic acid", and its scientific name is "3,4,5-trihydroxybenzoic acid". Molecular formula C 7 h 6 o 5 . Widely present in plants such as Rhubarb palmatum, Eucalyptus eucalyptus, and dogwood, it is a polyphenolic compound that exists in nature and is widely used in the fields of food, biology, medicine, and chemical industry. As a polyphenol, gallic acid can protect cells from oxidative damage, significantly reduce lipid peroxidation products, and has anti-oxidation, antibacterial, anti-viral, anti-tumor effects. It can treat joint diseases in medicine, promote blood circulation, remove blood stasis, and soothe Wind dissipates ...

Claims

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Application Information

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IPC IPC(8): C07C51/42C07C51/47C07C51/44C07C65/03
CPCC07C51/42C07C51/44C07C51/47C07C65/03Y02P20/54
Inventor 刘贺李泓胜张红运朱丹实李君杨立娜郝春光赵宏伟李晓娟
Owner BOHAI UNIV
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