Heart chip on basis of structural color hydrogel and application of heart chip

Abstract

The invention discloses a heart chip on the basis of structural color hydrogel. The heart chip comprises a chip top plate, a chip bottom plate and a s structural color hydrogel membrane. Myocardial cells grow on the structural color hydrogel membrane, the chip bottom plate is provided with a liquid storage micro-tank, one end of the liquid storage micro-tank is communicated with a liquid inlet inthe chip bottom plate via flow distribution micro-channels, the other end of the liquid storage micro-tank is communicated with a liquid outlet in the chip bottom plate, and hydrogel membrane mountingmicro-columns are arranged in the liquid storage micro-tank and are used for arranging the structural color hydrogel membrane; a liquid inlet hole and a liquid outlet hole are formed in the chip topplate and correspond to the liquid inlet and the liquid outlet in the chip bottom plate. The heart chip constructed on the basis of structural color hydrogel materials has the unique intrinsic advantages that complicated detection systems can be omitted, and the heart chip is intuitive and is free of influence in the physiological and pharmaceutical aspects and the like on detected systems; more importantly, detection methods are free of influence of factors such as external environments and chemical reagents, and the heart chip is sensitive and efficient during heart medicine screening and evaluation and is free of influence of external conditions.

Description

technical field [0001] The invention relates to a heart chip based on structural color hydrogel and its application, belonging to the field of organ chips. Background technique [0002] The human body is an organism composed of various complex organs. The interconnection between organs enables human beings to achieve various metabolic behaviors in the body. At present, for the development of drugs for humans, it is mainly through in vitro cell culture and animal in vivo experiments to detect the effect of drugs on target objects, so as to judge the characteristics of drugs; however, the two-dimensional cell structure produced by in vitro cell culture cannot truly simulate the human microenvironment As well as the complex physiological processes between various tissues and organs, while animal experiments are also restricted by the uncertainty of animal models, the complexity of different animals and some humanitarian factors; for this reason, constructing cells or organs at ...

AI Technical Summary

Problems solved by technology

At present, for the development of drugs for humans, it is mainly through in vitro cell culture and animal in vivo experiments to detect the effect of drugs on target objects, so as to judge the characteristics of drugs; however, the two-dimensional cell structure produced by in vitro cell culture cannot truly simulate the human microenvironment As well as the complex physiological processes between various tissues and organs, while animal experiments are also restricted by the uncertainty of animal models, the complexity of different animals and some humanitarian factors; for this reason, constructing cells or organs at the level of cells or organs Organ-on-a-chip to mimic real physiological processes has attracted widespread interest

[0003] The heart is one of the most important organs of the human body. The heart chip is an important way to realize the simulation of human heart function and detection behavior. However, the heart chip needs complex detection systems after construction, and these detection systems often consume a lot of time and energy. And Lack of intuition; in the research of heart and cardiomyocytes, the contractility and beating frequency of cardiomyocytes are the most important evaluation parameters, which are usually important indicators for judging cardiac function and cardiomyocyte activity; therefore, the research and development of Sensing materials for detecting the contractility and beating frequency of cardiomyocytes with high sensitivity, and the construction of a stable contraction force and beating frequency sensing heart chip and drug research platform are still facing severe challenges

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