Glomerulus system based on micro-fluidic chip and applications of glomerulus system

A technology of microfluidic chip and glomerulus, applied in the field of glomerular system, can solve the problem of inability to reproduce renal filtration function in vitro, and achieve the effect of reducing the failure rate
CN107955786AActive Publication Date: 2018-04-24DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Publication Date
2018-04-24

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Abstract

The invention relates to a glomerulus system based on a micro-fluidic chip and applications of the glomerulus system. The micro-fluidic chip is composed of a left main channel, a right main channel, acollagen channel, a collagen channel inlet, a left main channel inlet and a right main channel inlet, wherein the left main channel is connected to the left side of the collagen channel, and the right main channel is connected to the right side of the collagen channel; the left main channel is inoculated with a glomerulus micro-tissue, the right main channel is used as a collecting area, the filtering effect of the glomeruli can be observed, and the influences of the renal toxicity caused by the chemical ingredients on the filtering function of the glomeruli also can be observed. According tothe technical scheme, the construction of a glomerulus chip with the filtering function outside the body is realized, and the application in the kidney toxicity evaluation of the medicines is also realized.
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Description

technical field

[0001] The invention relates to the technical field of applying microfluidic chip technology to the construction of in vitro organ models, in particular to a glomerular system based on a microfluidic chip and its application. Background technique

[0002] Kidney is one of the main target organs of drug toxicity. The kidney is composed of more than 20 kinds of cells with different ultrastructure, metabolic capacity and transport function, and is an important organ for drug excretion. When chemical drugs are excreted by the kidneys, they will be selectively enriched in renal cells, causing damage to cell membranes, mitochondria, endoplasmic reticulum and lysosomes, destroying cell integrity, and causing renal cell apoptosis or necrosis. Reduce glomerular filtration and renal tubular reabsorption, resulting in an imbalance of water and electrolytes in the body, and even acute renal failure in severe cases. Therefore, observation of drug nephrotoxicity is an im...

Claims

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