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Vitamin premix suitable for soft capsule preparation and preparation method of vitamin premix

A vitamin premix and vitamin technology, which is applied in capsule delivery, pharmaceutical formula, food forming, etc., can solve the problem of no grading phenomenon, and achieve the effects of avoiding component changes, simple preparation process, and enhancing physical fitness

Inactive Publication Date: 2018-05-01
山东禹王制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to overcome the existing problems in the production of existing premixes, the present invention provides a vitamin premix suitable for soft capsules and a preparation method thereof. The particle fineness of the obtained vitamin premixes reaches the standard, and the coefficient of variation of material uniformity is less than 5%. No grading occurs during transportation

Method used

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  • Vitamin premix suitable for soft capsule preparation and preparation method of vitamin premix
  • Vitamin premix suitable for soft capsule preparation and preparation method of vitamin premix
  • Vitamin premix suitable for soft capsule preparation and preparation method of vitamin premix

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Embodiment 1: A kind of vitamin premix material suitable for soft capsule dosage form, consists of vitamin B 1 , Vitamin B 2 , vitamin C, niacinamide, vitamin B 6 , calcium pantothenate, vitamin B 12 , biotin, folic acid, maltodextrin, the process is as follows figure 1 shown.

[0033] The composition of raw materials is as follows:

[0034]

[0035] The preparation steps are as follows:

[0036] (1) Put vitamin B in a clean bag 1 , Vitamin B 2 , vitamin C, niacinamide, vitamin B 6 , calcium pantothenate, biotin, and folic acid are increased by the same amount. First, mix 0.2g of biotin with an equal amount of folic acid (0.2g) to obtain a 0.4g mixture; then add the same amount of folic acid (0.4g) as the mixture and mix , to get 0.8g mixture; then add the same amount of folic acid (0.6g) and vitamin B 1 (0.2g), to get 1.6g of the mixture; and so on, until the maximum amount of vitamin C is added, the mixture and maltodextrin are placed in a high-speed wet m...

Embodiment 2

[0039] Embodiment 2: As described in Embodiment 1, the difference is that the raw material weight composition is changed into:

[0040]

[0041] According to the method described in Example 1, the vitamin premix B suitable for soft capsule preparations was prepared.

Embodiment 3

[0042] Embodiment 3: as described in embodiment 1, difference is, raw material weight composition changes into:

[0043]

[0044] According to the method described in Example 1, the vitamin premix C suitable for soft capsule preparations was prepared.

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Abstract

The invention relates to a vitamin premix suitable for soft capsules and a preparation method of the vitamin premix. The vitamin premix comprises the following raw materials of vitamin B1, vitamin B2,vitamin C, nicotinamide, vitamin B6, calcium pantothenate, vitamin B12, biotin, folic acid and maltodextrin. The preparation method comprises the following steps of making the raw materials into softmaterials, performing drying, performing crushing, and performing screening so as to make uniform fine powder of which the fineness is greater than or equal to 100 meshes. According to the vitamin premix and the preparation method thereof, a technology for making the soft materials by a wet method material mixing manner is firstly used, so that the condition of component changes caused by spray drying and high temperature generally used in the preparation of the premix is avoided. The fineness of granules of the prepared vitamin premix can achieve 200 meshes, the materials are uniformly distributed, the classifying phenomenon in the production and transportation process cannot occur, and the stability is good.

Description

technical field [0001] The invention relates to a vitamin premix suitable for soft capsule preparations and a preparation method thereof, belonging to the technical field of vitamin nutritional preparations. Background technique [0002] Vitamins are a type of trace organic substances that must be obtained from food to maintain normal physiological functions of humans, and play an important role in the growth, metabolism, and development of the human body. Such substances are neither raw materials for body tissue nor sources of energy, but a class of regulating substances that play an important role in substance metabolism. With the acceleration of the pace of life, it is difficult to ensure the human body’s demand for vitamins only through food supplements. Multidimensional soft capsules are a preparation that can supplement various vitamins at the same time. It mainly uses soybean oil and beeswax as auxiliary materials, but it is easy to cause oil leakage. The main reason...

Claims

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Application Information

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IPC IPC(8): A23L33/15A23L33/155A23P10/22A61K31/714A61K9/48A61P3/02A61K31/525A61K31/519A61K31/51A61K31/455A61K31/4415A61K31/4188A61K31/375A61K31/197
CPCA23L33/15A23L33/155A23P10/22A23V2002/00A61K9/4866A61K31/197A61K31/375A61K31/4188A61K31/4415A61K31/455A61K31/51A61K31/519A61K31/525A61K31/714A23V2200/30A23V2250/7044A23V2250/7052A23V2250/7042A23V2250/7046A23V2250/708A23V2250/706A23V2250/7056A61K2300/00
Inventor 刘汝萃范书琴张建全肖晶马良
Owner 山东禹王制药有限公司
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