Medicine-carried mesoporous silica coated polypyrrole nanoparticles and preparation method thereof
A mesoporous silica and pyrrole nanotechnology, which is applied in the field of medical drugs, can solve the problems of low drug-loading capacity of polypyrrole nanoparticles, drug toxicity and side effects, etc.
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Embodiment 1
[0018] 1. Preparation of Polypyrrole Nanoparticles
[0019] Weigh 299.8 mg of polyvinyl alcohol, add 20 mL of water, stir at room temperature for 0.5 h to disperse, heat and stir in a water bath at 70 to 80 °C for 0.5 h to fully dissolve, and after the solution returns to room temperature, add 255.6 mg of iron trichloride hexa Hydrate, stirred at room temperature for 1 hour, then added 28 μL of pyrrole monomer solution to it, reacted for 4 hours under low temperature conditions (figure 1 (A) shown.
[0020] 2. Preparation of Mesoporous Silica Nanoparticles
[0021] Weigh 0.1g of cetyltrimethylammonium bromide, add 48mL of water, heat and stir in a water bath at 80°C to dissolve, add 0.35mL of 2.0M aqueous sodium hydroxide solution, stir and mix well, then add 0.5mL of ethyl orthosilicate dropwise Esters, stirred at room temperature for 3 hours, centrifuged, washed with hot water and ethanol several times to obtain silica nanoparticles. Prepare 34mL of concentrated hydrochlor...
Embodiment 2
[0028] 1. Infrared spectral analysis
[0029] The polypyrrole nanoparticles, mesoporous silica nanoparticles and mesoporous silica-coated polypyrrole nanoparticles were respectively analyzed by Fourier transform infrared spectroscopy. The characterization results are as follows: image 3 shown. The results showed that the characteristic absorption peak of silicon dioxide appeared in all three samples: 1099cm -1 The stretching vibration peak of Si-O-Si is at 3441cm -1 is the stretching vibration peak of -OH. Compared with the infrared spectrum of blank polypyrrole (PPy) nanoparticles, the spectrum of polypyrrole nanoparticles coated with mesoporous silica (PPy@MSN) is obviously different, and the PPy nanoparticles and silica nanoparticles appear. Characteristic peaks. Furthermore, compared with the infrared spectrum of blank mesoporous silica nanoparticles (MSN), the spectrum of PPy@MSN is at 1635cm -1 The obvious pyrrole ring C=C stretching vibration peak appeared at , wh...
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