Medicine-carried mesoporous silica coated polypyrrole nanoparticles and preparation method thereof

A mesoporous silica and pyrrole nanotechnology, which is applied in the field of medical drugs, can solve the problems of low drug-loading capacity of polypyrrole nanoparticles, drug toxicity and side effects, etc.

Inactive Publication Date: 2018-05-01
CHONGQING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a new drug-loaded mesoporous silica-coated polypyrrole nanoparticle and its preparation method for the problems of low drug-loading capacity of polypyrrole nanoparticles and the toxic and side effects of the loaded drugs.

Method used

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  • Medicine-carried mesoporous silica coated polypyrrole nanoparticles and preparation method thereof
  • Medicine-carried mesoporous silica coated polypyrrole nanoparticles and preparation method thereof
  • Medicine-carried mesoporous silica coated polypyrrole nanoparticles and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0018] 1. Preparation of Polypyrrole Nanoparticles

[0019] Weigh 299.8 mg of polyvinyl alcohol, add 20 mL of water, stir at room temperature for 0.5 h to disperse, heat and stir in a water bath at 70 to 80 °C for 0.5 h to fully dissolve, and after the solution returns to room temperature, add 255.6 mg of iron trichloride hexa Hydrate, stirred at room temperature for 1 hour, then added 28 μL of pyrrole monomer solution to it, reacted for 4 hours under low temperature conditions (figure 1 (A) shown.

[0020] 2. Preparation of Mesoporous Silica Nanoparticles

[0021] Weigh 0.1g of cetyltrimethylammonium bromide, add 48mL of water, heat and stir in a water bath at 80°C to dissolve, add 0.35mL of 2.0M aqueous sodium hydroxide solution, stir and mix well, then add 0.5mL of ethyl orthosilicate dropwise Esters, stirred at room temperature for 3 hours, centrifuged, washed with hot water and ethanol several times to obtain silica nanoparticles. Prepare 34mL of concentrated hydrochlor...

Embodiment 2

[0028] 1. Infrared spectral analysis

[0029] The polypyrrole nanoparticles, mesoporous silica nanoparticles and mesoporous silica-coated polypyrrole nanoparticles were respectively analyzed by Fourier transform infrared spectroscopy. The characterization results are as follows: image 3 shown. The results showed that the characteristic absorption peak of silicon dioxide appeared in all three samples: 1099cm -1 The stretching vibration peak of Si-O-Si is at 3441cm -1 is the stretching vibration peak of -OH. Compared with the infrared spectrum of blank polypyrrole (PPy) nanoparticles, the spectrum of polypyrrole nanoparticles coated with mesoporous silica (PPy@MSN) is obviously different, and the PPy nanoparticles and silica nanoparticles appear. Characteristic peaks. Furthermore, compared with the infrared spectrum of blank mesoporous silica nanoparticles (MSN), the spectrum of PPy@MSN is at 1635cm -1 The obvious pyrrole ring C=C stretching vibration peak appeared at , wh...

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Abstract

The invention discloses medicine-carried mesoporous silica coated polypyrrole nanoparticles and a preparation method thereof. The preparation method comprises preparation of polypyrrole nanoparticlesand preparation of the medicine-carried mesoporous silica coated polypyrrole nanoparticles. The medicine-carried mesoporous silica coated polypyrrole nanoparticles prepared by the preparation method disclosed by the invention are simple in preparation process, low in production cost and easy in industrial production. On the one hand, the novel nano preparation enters the tumor stroma through an EPR (Enhanced Permeability and Retention) effect of a tumor site to realize passive targeted drug delivery of the tumor, thereby improving the bioavailability of the drug, reducing the toxic and side effects of the drug and enhancing the therapeutic action of the drug; and on the other hand, polypyrrole coated in the novel nano preparation has very high photothermal conversion efficiency, so that the novel nano preparation can simultaneously perform photothermal therapy and realize photoacoustic imaging and has potential clinical application values.

Description

technical field [0001] The invention belongs to the field of medical drugs, and in particular relates to a drug-loaded mesoporous silica-coated polypyrrole nanoparticle and a preparation method thereof. Background technique [0002] Tumor photothermal therapy is one of the hotspots in the field of pharmaceutical research. Photothermal therapy refers to the use of materials with high photothermal conversion efficiency, injecting them into the human body, using targeted recognition technology to gather them near the tumor tissue, and irradiating them with an external light source (usually near-infrared light). A treatment in which light energy is converted into heat to kill cancer cells. The organism itself has little absorption of light in the near-infrared region of 700-1100nm, so the light in this region has very good penetration into biological tissues. However, organic photothermal conversion materials have obvious absorption of near-infrared light, and because the elec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K49/22A61K47/69A61P35/00
CPCA61K41/0052A61K49/228
Inventor 张良珂朱文静
Owner CHONGQING MEDICAL UNIVERSITY
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