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Felodipine sustained-release tablet

A gentle and non-alcoholic technology, applied in the field of medicine, can solve the problems of non-constant release rate, not close to constant rate, and not stable blood pressure, so as to improve compliance, uniform release rate and reduce blood pressure fluctuations Effect

Inactive Publication Date: 2018-05-04
SOUTHWEST MEDICAL UNIVERISTY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the sustained-release tablets currently available in the market have the problem that the release rate is not constant or not close to the constant rate, which leads to insufficient blood pressure reduction and reduces the clinical application effect of felodipine sustained-release tablets.

Method used

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  • Felodipine sustained-release tablet
  • Felodipine sustained-release tablet
  • Felodipine sustained-release tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021]

[0022]

Embodiment 2

[0024]

Embodiment 3

[0026]

[0027]

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Abstract

The invention belongs to the technical field of drugs, and relates to a felodipine sustained-release tablet. The felodipine sustained-release tablet is prepared from the following components in weightby percent: 1 to 5% of felodipine, 5 to 20% of hydroxypropyl methylcellulose, 1 to 10% of hydroxypropyl cellulose, 10 to 40% of hydrophobic fillers, 40 to 70% of hydrophilic fillers, and 5 to 20% ofother pharmaceutical excipients. The felodipine sustained-release tablet can make release degree of the drugs more uniform at a constant speed.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a felodipine slow-release tablet. Background technique [0002] Felodipine, chemical name is (±)-2,6-Dimethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate ethyl ester , the English name is FELODIPINE, the molecular formula is C18H19Cl2NO4, the molecular weight is 384.25, and the chemical structure is as follows: [0003] [0004] It is white to light yellow crystal or crystalline powder; odorless, tasteless; unstable when exposed to light; easily soluble in acetone, methanol or ethanol, almost insoluble in water. [0005] Felodipine is a new type of dihydropyridine calcium channel blocker with a high degree of vascular selectivity, with a selectivity ratio of 100 for blood vessels and heart. Lowers arterial pressure by lowering peripheral vascular resistance, has no direct effect on myocardial contractility and cardiac conduction within the therapeutic dose...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/4422A61K47/38A61P9/12
Inventor 赵领魏郁梦皮超刘浩胡美郑文武叶云邓以平
Owner SOUTHWEST MEDICAL UNIVERISTY
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