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Method for preparing phensuximide molecular imprinting electrochemical sensor

A technology of molecular imprinting and phensuccinyl, which is applied in scientific instruments, instruments, analytical materials, etc., can solve the problems of poor cross-linking rigidity, low sensitivity, inability to properly match functional monomers and template molecules, etc., and achieve easy production , simple equipment, excellent sensitivity effect

Inactive Publication Date: 2018-05-04
GUANGXI UNIV FOR NATITIES
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  • Abstract
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  • Application Information

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Problems solved by technology

The current method is not sensitive because the selected functional monomers cannot be properly matched with the template molecules, and the rigidity of the cross-linking is also poor.

Method used

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  • Method for preparing phensuximide molecular imprinting electrochemical sensor

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Embodiment 1

[0014] 1. Treatment of glassy carbon electrodes

[0015] The glassy carbon electrode was polished with 1.0 μm, 0.3 μm and 0.05 μm alumina powder on a polishing cloth in turn, then placed in nitric acid with a volume ratio of 1:1 for 8 minutes, and then placed in absolute ethanol for 8 minutes , and finally ultrasonically cleaned with pure water.

[0016] 2. Preparation of phenylsuccinyl molecularly imprinted electrochemical sensor

[0017] To 10.0 mL of solvent ethanol, add 1.0 mmol of template molecule phensuximide, 3.0 mmol of functional monomer young shoots containing broken oxyloganin, 3.0 mmol of cross-linking agent N-trans-feruloyl tyramide, 0.10 mmol Initiator azobisisobutyronitrile and 0.0600 g of nanoclay, each adding a chemical reagent ultrasonically dissolved for 8 minutes;

[0018] Take 8 μL of the mixture in step and apply it on the surface of a clean and smooth glassy carbon electrode with a diameter of 2 mm. After standing for 6 hours, place the modified el...

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Abstract

The invention discloses a method for preparing a phensuximide molecular imprinting electrochemical sensor. The method comprises the following steps: taking phensuximide as a template molecule, takingloganin containing broken oxidation in young branches as a functional monomer, taking azodiisobutyronitrile as an initiator, taking nanometer clay as a doping agent, and taking N-trans-feruloyltyramine as a cross-linking agent, thereby obtaining the high-sensitivity nanometer clay doped phensuximide molecular imprinting electrochemical sensor. The analytical method is simple and practical, and overcomes the defects that the conventional method is complicated, expensive in equipment and low in sensitivity.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a preparation method of a benzsuccinyl molecularly imprinted electrochemical sensor. Background technique [0002] Phensuximide, the chemical name is 1-methyl-3-phenylpyrrolidine-2,5-dione. Bensuximide is an antiepileptic drug mainly used for absence seizures and clonic seizures, but not for tonic-clonic and partial seizures. It can be used with other antiepileptic drugs for mixed seizures. For the treatment of absence status epilepticus, it has a good effect. The advantages of phensuximide are that it is safe, effective, has a long elimination half-life, and can control seizures with a single dose per day. The main disadvantage is that long-term or excessive use of such drugs can lead to liver and kidney damage and lupus erythematosus. [0003] Methods for the determination of phensuccinyl include gas chromatography-mass spectrometry, high performance liquid ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/6893
Inventor 陈其锋马祥英刘绍刚余会成韦贻春
Owner GUANGXI UNIV FOR NATITIES