Tablet containing olmesartan medoxomil and preparation method of tablet

A technology of olmesartan medoxomil tablet and olmesartan medoxomil tablet, which is applied in the field of olmesartan medoxomil tablet and its preparation, can solve the problems of easy splitting of olmesartan medoxomil and low dissolution rate of olmesartan medoxomil in vitro, and achieve Covering bad odor, improving bioavailability, and improving the effect of sticking phenomenon

Active Publication Date: 2018-05-08
YANGZIJIANG PHARMA GROUP SHANGHAI HAINI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese invention CN104398485A discloses a kind of olmesartan medoxomil tablet and its preparation method, it adds a kind of polymer material polylactic acid i...

Method used

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  • Tablet containing olmesartan medoxomil and preparation method of tablet
  • Tablet containing olmesartan medoxomil and preparation method of tablet
  • Tablet containing olmesartan medoxomil and preparation method of tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The preparation of embodiment 1 olmesartan medoxomil tablet

[0034] The prescription composition of 10000 described olmesartan medoxomil tablets

[0035] Tablet prescription:

[0036]

[0037] Coating:

[0038]

[0039] Preparation:

[0040] (1) Olmesartan medoxomil is pulverized by air flow, and the pulverization parameters are set to: feeding speed 150V, feeding pressure 0.7Mpa, pulverizing pressure 0.5Mpa; Detect particle diameter with Beckman laser particle size analyzer; Olmesartan medoxomil after pulverizing and Silica mixed through a 30-mesh sieve;

[0041] (2) Adding in sequence: lactose, the sieved mixture of pulverized olmesartan medoxomil and silicon dioxide, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose were premixed in a three-dimensional mixer for 30 minutes. Then add the magnesium stearate of recipe quantity and mix 5min;

[0042] (3) According to the content detection result, the prepared olmesartan medoxomil blend m...

Embodiment 2

[0044] The preparation of embodiment 2 olmesartan medoxomil tablets

[0045] The prescription composition of 10000 described olmesartan medoxomil tablets

[0046]

[0047] Coating:

[0048]

[0049] The preparation method is the same as in Example 1.

Embodiment 3

[0050] The preparation of embodiment 3 olmesartan medoxomil tablets

[0051] The prescription composition of 10000 described olmesartan medoxomil tablets

[0052] Tablet prescription:

[0053]

[0054] Coating:

[0055]

[0056]

[0057] The preparation method is the same as in Example 1.

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Abstract

The invention discloses a tablet containing olmesartan medoxomil and a preparation method of the tablet. The tablet is composed of olmesartan medoxomil, a disintegrating agent, a filling agent, a diluent, an anti-sticking agent and a lubricating agent. The preparation method disclosed by the invention comprises the following steps: performing jet milling treatment on olmesartan medoxomil, and mixing with the anti-sticking agent to pass through a 30-mesh sieve; mixing with other medicinal auxiliary materials, and directly tabletting; performing film coating on the tablet core after tabletting,wherein the film coating premixed agent is composed of the following materials: hydroxypropyl methylcellulose, titanium dioxide and polyethylene glycol. The olmesartan medoxomil tablet provided by theinvention is high in in-vitro dissolution rate, high in bioavailability, excellent in stability and mechanical strength, less in odor, sticking-free and suitable for large-scale mass production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to an olmesartan medoxomil tablet and a preparation method thereof. Background technique [0002] Hypertension is the most common disease with the highest incidence rate in the world. According to statistics, the number of hypertensive patients in my country has exceeded 100 million, and it is showing a younger trend. Among various cardiovascular and cerebrovascular diseases, the prevalence rate caused by hypertension is the highest. Olmesartan medoxomil tablet is a preparation product with good clinical blood pressure lowering effect developed and widely used in recent years. As a prodrug, it is absorbed through the gastrointestinal tract and rapidly and completely deesterified into olmesartan. Olmesartan is a selective angiotensin II type 1 receptor (AT1) antagonist, which blocks the vasoconstrictive effect of angiotensin II by selectively blocki...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K31/4178A61K47/38A61K47/04A61K47/26A61P9/12
CPCA61K9/2009A61K9/2018A61K9/2054A61K9/2095A61K9/2866A61K31/4178
Inventor 潘新冯天才姜锋其他发明人请求不公开姓名
Owner YANGZIJIANG PHARMA GROUP SHANGHAI HAINI PHARMA
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