Detection method of purity of 3-ethoxy-4-methoxybenzaldehyde

A methoxybenzaldehyde and detection method technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., to achieve the effect of reliable detection method, high repeatability, and simple detection method

Active Publication Date: 2018-05-08
GUANGXI ENANTIOTECH PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report on the detection of the purity of 3-ethoxy-4-methoxybenzaldehyde by high performance liquid chromatography.

Method used

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  • Detection method of purity of 3-ethoxy-4-methoxybenzaldehyde
  • Detection method of purity of 3-ethoxy-4-methoxybenzaldehyde
  • Detection method of purity of 3-ethoxy-4-methoxybenzaldehyde

Examples

Experimental program
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Effect test

Embodiment 1

[0030] A method for detecting the purity of 3-ethoxy-4-methoxybenzaldehyde includes the following steps:

[0031] 1) System adaptability solution preparation: Take appropriate amount of 3-ethoxy-4-methoxybenzaldehyde, isovanillin and ethyl vanillin in the same volumetric flask, dissolve it with acetonitrile, and configure it to each milliliter A solution containing 1 mg of 3-ethoxy-4-methoxybenzaldehyde, isovanillin and ethyl vanillin to obtain a system suitability solution;

[0032] 2) Preparation of test product solution: Take an appropriate amount of test product 3-ethoxy-4-methoxybenzaldehyde, dissolve it with acetonitrile, and configure it into a solution with a concentration of 0.5 mg / mL to obtain the test product solution;

[0033] 3) Blank test: accurately measure 20μL of acetonitrile, inject it into the liquid chromatograph, and record the chromatogram;

[0034] 4) System adaptability test: accurately measure 5μL of the system adaptability solution, inject it into the liquid ...

Embodiment 2

[0049] A method for detecting the purity of 3-ethoxy-4-methoxybenzaldehyde includes the following steps:

[0050] 1) System adaptability solution preparation: Take appropriate amount of 3-ethoxy-4-methoxybenzaldehyde, isovanillin and ethyl vanillin in the same volumetric flask, dissolve it with acetonitrile, and configure it to each milliliter A solution containing 1 mg of 3-ethoxy-4-methoxybenzaldehyde, isovanillin and ethyl vanillin to obtain a system suitability solution;

[0051] 2) Preparation of test product solution: Take an appropriate amount of test product 3-ethoxy-4-methoxybenzaldehyde, dissolve it with acetonitrile, and configure it into a solution with a concentration of 0.6 mg / mL to obtain the test product solution;

[0052] 3) Blank test: accurately measure 20μL of acetonitrile, inject it into the liquid chromatograph, and record the chromatogram;

[0053] 4) System adaptability test: Precisely measure 10μL of the system adaptability solution, inject it into the liquid ...

Embodiment 3

[0062] A method for detecting the purity of 3-ethoxy-4-methoxybenzaldehyde includes the following steps:

[0063] 1) System adaptability solution preparation: Take appropriate amount of 3-ethoxy-4-methoxybenzaldehyde, isovanillin and ethyl vanillin in the same volumetric flask, dissolve it with acetonitrile, and configure it to each milliliter A solution containing 1 mg of 3-ethoxy-4-methoxybenzaldehyde, isovanillin and ethyl vanillin to obtain a system suitability solution;

[0064] 2) Preparation of test product solution: Take an appropriate amount of test product 3-ethoxy-4-methoxybenzaldehyde, dissolve it with acetonitrile, and configure it into a solution with a concentration of 0.5-1 mg / mL to obtain the test product solution;

[0065] 3) Blank test: accurately measure 20μL of acetonitrile, inject it into the liquid chromatograph, and record the chromatogram;

[0066] 4) System adaptability test: Precisely measure 15μL of the system adaptability solution, inject it into the liqui...

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Abstract

The invention discloses a detection method of purity of 3-ethoxy-4-methoxybenzaldehyde. In the detection method, a phenomenon chromatographic column is adopted, two mobile phases are adopted for gradient elution, a mobile phase A is KH2PO4 buffer solution, a mobile phase B is acetonitrile, and the flow velocity of the each mobile phase is 0.7-1.2mL / min; a detector is an ultraviolet detector. The detection method is simple, convenient, accurate, fast, reliable, highly repeatable and stable, the 3-ethoxy-4-methoxybenzaldehyde and known impurities thereof can be effectively separated, and the simple, convenient, accurate, fast and reliable detection method is provided for industrial production of the 3-ethoxy-4-methoxybenzaldehyde.

Description

Technical field [0001] The present invention relates to the technical field of material purity analysis, in particular to the detection of the purity of 3-ethoxy-4-methoxybenzaldehyde, known impurities and unknown impurities, and more specifically to the detection of 3-ethoxy by liquid chromatography. The purity of 4-methoxybenzaldehyde, known impurities, unknown impurities. Background technique [0002] The chemical formula of 3-ethoxy-4-methoxybenzaldehyde is C 10 H 12 O 3 , Its CAS number is 1131-52-8, which is an important intermediate for the production of Apster. The impurity content of 3-ethoxy-4-methoxybenzaldehyde is an important indicator to measure its quality. If its impurity content is too high, it will affect the efficacy and quality of the prepared Aplast, because of its purity and impurities It directly affects the purity of Apsite and the size of impurities. [0003] High performance liquid chromatography has the advantages of high resolution, high sensitivity, h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 蒙发明邓超芹徐亮曹欢燕
Owner GUANGXI ENANTIOTECH PHARM CO LTD
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