High-throughput droplet generation and collection device based on density regulation

Abstract

The invention discloses a high-throughput drop formation and collection device based on density control, which comprises a box body and a drop high-throughput formation module, a buoyancy regulation module and a drop rapid collection module which are arranged in the box body. The drop formation module, the buoyancy regulation module and the drop rapid collection module are positioned in the box body from bottom to top. A micro-passage bottom plate with a fluid uniform dispersion structure on the lower layer of the drop high-throughput formation part module can implement uniform injection of disperse phase liquid; a cover plate layer of array through holes, which has two stages of pressure gradients, on the upper layer of the drop high-throughput formation module can implement formation ofa great amount of drops, stabilizes a pressure when the drops are formed, avoid mutual disturbance, controls sizes of the formed drops and avoids damage generated due to drop collision. The buoyancy regulation module changes a buoyancy and a surface tension which are applied to the disperse phase liquid by regulating a density of continuous phase liquid so as to implement drop formation based on density control, control the size of the formed drops and regulate a rate of drop formation.

Description

technical field [0001] The present invention relates to a droplet generation and collection device, in particular to a high-flux droplet generation and collection device based on density control designed to realize droplet mass production and control droplet generation rate. Background technique [0002] Micro-droplets are a technology developed on microfluidic chips in recent years to manipulate tiny volumes of liquids. phase, the continuous phase and the dispersed phase enter the microchannel at the same time, under the action of the microchannel, the dispersed phase is distributed in the continuous phase in the form of tiny volume units, forming a series of discrete microdroplets, each microdroplet can be used as A microreactor that completes a set of chemical or biological reactions. [0003] At present, the preparation of microdroplets in microfluidic chips mainly relies on designing different microchannels for continuous generation. However, the droplet generation me...

AI Technical Summary

Problems solved by technology

However, the droplet generation method in the existing microfluidic chip is still difficult to achieve not only good monodispersity, but also high-throughput production of micro-droplets. In the case of synthesis, it is difficult to meet the needs of a large number of droplet production

At the same time, it is difficult to ensure that the amount of fluid in each channel is relatively consistent in the microchannel, and the droplets will collide when they flow through the pipeline, which seriously affects the shape of the droplets.

The existing way to adjust the droplet generation speed is to change the injection speed of the dispersed phase or the continuous phase, but the realization method is in the form of emulsification one drop at a time, which affects the generation of a large number of droplets, and if the high-density liquid is directly injected into the generation device , the liquid is difficult to mix evenly, resulting in uneven distribution of liquid density everywhere, affecting the formation of droplets

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