Donepezil hydrochloride oral instantfilm agent and preparation method thereof

Abstract

The invention belongs to the field of pharmaceutical preparations and relates to a donepezil hydrochloride oral instant film agent adopting a simple technical process and a preparation method of the donepezil hydrochloride oral instant film agent. The oral instant film agent with good taste, provided by the invention, is prepared from the following components in percentage by weight: 1 to 40 percent of donepezil hydrochloride, 20 to 80 percent of film-forming material, 1 to 20 percent of plasticizer, 1 to 20 percent of taste masking agent, 10 to 30 percent of filler and 0 to 5 percent of otherauxiliary materials. The preparation method is simple; the donepezil hydrochloride oral instant film agent is prepared by directly dissolving all the components in an appropriate solvent, uniformly dispersing, coating on a backing material and drying. The prepared film agent has the advantages of uniform and smooth appearance, good physical and mechanical properties, high dissolution speed and good taste; in addition, the donepezil hydrochloride oral instant film agent is easy to carry and can improve the compliance of medication of patients with Alzheimer's disease.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a donepezil hydrochloride oral instant film and a preparation method thereof. Background technique [0002] Alzheimer's disease is a neurodegenerative disease with insidious onset and progressive development, commonly known as senile dementia. Alzheimer's disease was discovered in the last century. It often starts in old age or early old age. It usually develops slowly and progresses gradually. The etiology of generalized dementia such as personality and behavioral changes is still unknown, and clinical treatment is still facing great challenges. It is generally believed that the prevalence rate will double for every 5 years of age increase. In today's increasingly serious aging situation, Alzheimer's disease has become a serious social public health problem, a major disease affecting human health, and a heavy burden for society and families. [0003] Donepezil hydro...

AI Technical Summary

Problems solved by technology

Alzheimer's disease was discovered in the last century. It often starts in old age or early old age. It usually develops slowly and progresses gradually. Generalized dementia such as personality and behavior changes, the etiology is still unknown, and clinical treatment is still facing great challenges

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