Donepezil hydrochloride oral instantfilm agent and preparation method thereof

A technology of donepezil hydrochloride and oral fast-dissolving film, applied in the field of donepezil hydrochloride oral fast-dissolving film and preparation thereof, can solve problems such as damage to visual space skills, and achieve the effect of solving bitterness and paralysis

Inactive Publication Date: 2018-05-29
CHINA PHARM UNIV
View PDF7 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Alzheimer's disease was discovered in the last century. It often starts in old age or early old age. It usually develops slowly and progresses gradually

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Donepezil hydrochloride oral instantfilm agent and preparation method thereof
  • Donepezil hydrochloride oral instantfilm agent and preparation method thereof
  • Donepezil hydrochloride oral instantfilm agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0013] Example 1

[0014]

[0015]

[0016] Specific preparation process: Weigh Kollicoat IR and glycerin, stir and dissolve in a 60℃ water bath, add donepezil hydrochloride, sucralose, glycyrrhizin, menthol, and titanium dioxide and continue to stir to make them fully dissolved and dispersed. After uniform dispersion, ultrasonic 30min degassing , Coat evenly on the glass plate, dry at 60℃, and cut into 2×1.5cm 2 Large and small film, get donepezil hydrochloride oral instant film.

Example Embodiment

[0017] Example 2

[0018]

[0019] Specific preparation process: Weigh Kollicoat IR and glycerin, stir and dissolve in a 60℃ water bath, add donepezil hydrochloride, sucralose, glycyrrhizin, menthol, and titanium dioxide and continue to stir to make them fully dissolved and dispersed. After uniform dispersion, ultrasonic 30min degassing , Uniformly coated on a glass plate, dried at 60°C, and cut into 2×1.5cm2 size membranes to obtain Donepezil hydrochloride oral instant film.

Example Embodiment

[0020] Example 3

[0021]

[0022] Specific preparation process: Weigh the film-forming material HPMC E5 and glycerin, stir and dissolve in a 60°C water bath, add donepezil hydrochloride, sucralose, glycyrrhizin, menthol, and titanium dioxide and continue to stir to make them fully dissolved and dispersed. After uniform dispersion, ultrasonic 30min degassed, evenly coated on glass plate, dried at 60℃, cut into 2×1.5cm 2 Large and small film, get donepezil hydrochloride oral instant film.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the field of pharmaceutical preparations and relates to a donepezil hydrochloride oral instant film agent adopting a simple technical process and a preparation method of the donepezil hydrochloride oral instant film agent. The oral instant film agent with good taste, provided by the invention, is prepared from the following components in percentage by weight: 1 to 40 percent of donepezil hydrochloride, 20 to 80 percent of film-forming material, 1 to 20 percent of plasticizer, 1 to 20 percent of taste masking agent, 10 to 30 percent of filler and 0 to 5 percent of otherauxiliary materials. The preparation method is simple; the donepezil hydrochloride oral instant film agent is prepared by directly dissolving all the components in an appropriate solvent, uniformly dispersing, coating on a backing material and drying. The prepared film agent has the advantages of uniform and smooth appearance, good physical and mechanical properties, high dissolution speed and good taste; in addition, the donepezil hydrochloride oral instant film agent is easy to carry and can improve the compliance of medication of patients with Alzheimer's disease.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a donepezil hydrochloride oral instant film and a preparation method thereof. Background technique [0002] Alzheimer's disease is a neurodegenerative disease with insidious onset and progressive development, commonly known as senile dementia. Alzheimer's disease was discovered in the last century. It often starts in old age or early old age. It usually develops slowly and progresses gradually. The etiology of generalized dementia such as personality and behavioral changes is still unknown, and clinical treatment is still facing great challenges. It is generally believed that the prevalence rate will double for every 5 years of age increase. In today's increasingly serious aging situation, Alzheimer's disease has become a serious social public health problem, a major disease affecting human health, and a heavy burden for society and families. [0003] Donepezil hydro...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/70A61K47/28A61K47/26A61K47/10A61K47/32A61K31/445A61P25/28
Inventor 涂家生杨慧何东升
Owner CHINA PHARM UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap