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Controlled degradation magnesium-based functional gradient material and preparation method thereof

A technology of functionally graded materials and base materials, applied in electrolytic coatings, metal material coating processes, coatings, etc., can solve problems such as poor corrosion resistance, poor controllability of degradation, inability to be absorbed and degraded, and achieve high bonding strength. , good biocompatibility

Active Publication Date: 2018-06-01
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The bone implant materials widely used clinically are mainly titanium alloy and stainless steel, but their implants cannot be absorbed and degraded in the body. When the injured bone heals, a second operation is required to remove it, which increases the physiological pain and economic burden of the patient. Therefore, more and more attention has been paid to replacing traditional medical metal materials with biomedical degradable materials.
Magnesium alloy has good biodegradability and biocompatibility, and can be gradually degraded in the human body through corrosion. It is expected to become a new type of bone implant material. However, magnesium-based alloys used as implant materials have insufficient mechanical properties and poor corrosion resistance. , the poor controllability of degradation has become an obstacle to its clinical application

Method used

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  • Controlled degradation magnesium-based functional gradient material and preparation method thereof
  • Controlled degradation magnesium-based functional gradient material and preparation method thereof
  • Controlled degradation magnesium-based functional gradient material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0038] A method for preparing a controllable degradation magnesium-based functionally graded material, comprising the following steps:

[0039] 1) The size of the as-cast Mg-Zn-Y-Nd plate is 200mm×50mm×8mm, and it is subjected to homogenization annealing treatment, the annealing temperature is 500°C, and the holding time is 120 hours, and the annealed magnesium alloy plate is taken out of the heat treatment furnace , naturally cooled at room temperature;

[0040] 2) Polish the surface until it is bright, and drill holes with a drill bit with a diameter of 4mm. The hole distribution is designed to be 3 rows, and the distance between the rows is 2.5mm. The distance between the holes in the same row is 16.6mm, and the hole diameter is 4mm. The hole depth is 4mm, and the distribution and quantity of the holes are referred to the stirring needle (see image 3 ), loading of hydroxyapatite (HA) after drilling;

[0041] 3) Fix the magnesium alloy plate loaded with HA on the friction...

Embodiment 2

[0052] A method for preparing a controllable degradation magnesium-based functionally graded material, comprising the following steps:

[0053] 1) The size of the as-cast Mg-Zn-Y-Nd plate is 200mm×50mm×8mm, and it is subjected to homogenization annealing treatment at an annealing temperature of 450°C and kept for 80 hours, and the annealed magnesium alloy plate is taken out of the heat treatment furnace , naturally cooled at room temperature;

[0054] 2) Polish the surface until it is bright, and drill holes with a drill bit with a diameter of 2mm. The hole distribution is designed to be 4 rows, and the distance between the rows is 1mm. The distance between the holes in the same row is 3mm, and the hole diameter is 2mm. The depth is 2mm, and the loading of hydroxyapatite (HA) is carried out after the drilling is completed;

[0055] 3) Fix the magnesium alloy plate loaded with HA on the friction stir processing workbench for friction stir processing. The amount is 1.5mm, and ...

Embodiment 3

[0060] A method for preparing a controllable degradation magnesium-based functionally graded material, comprising the following steps:

[0061] 1) The size of the as-cast Mg-Zn-Y-Nd plate is 200mm×50mm×8mm, and it is subjected to homogenization annealing treatment, the annealing temperature is 200°C, and the holding time is 12 hours. The annealed magnesium alloy plate is taken out from the heat treatment furnace, and cooled naturally at room temperature;

[0062] 2) Polish the surface until it is bright, and drill holes with a drill bit with a diameter of 0.5mm. The hole distribution is designed to be 6 rows, the distance between rows is 3mm, the distance between holes in the same row is 1mm, and the hole diameter is 0.5mm , the hole depth is 1mm. Hydroxyapatite (HA) loading after drilling;

[0063] 3) Fix the magnesium alloy plate loaded with HA on the friction stir processing workbench for friction stir processing. The amount is 0.5mm, and the Mg base / HA layer with a thic...

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Abstract

The invention discloses a preparation method of a controlled degradation magnesium-based functional gradient material. The method comprises the steps of (1) annealing treatment of a magnesium alloy; (2) drilling of the annealed magnesium alloy; (3) HA or beta-TCP loading of the drilled magnesium alloy; (4) friction stir processing of the magnesium alloy loaded with hydroxyapatite or tricalcium phosphate, specifically, under the conditions that the rotary speed is 300-1700 r / min, the feeding speed is 10-50 mm / min and the press amount is 0.5-3 mm, 2-6 passes of friction stirring are conducted, and an Mg-based / HA layer or Mg-based / beta-TCP layer which is 0.5-3 mm thick is obtained; and (5) surface grinding, cleaning and drying with the Mg-based / HA layer or Mg-based / belt-TCP layer as the substrate material, and then electro-deposition so as to obtain a hydroxyapatite coating being 1-12 [mu]m thick on the surface of the substrate material, so that the controlled degradation magnesium-basedfunctional gradient material is obtained. The controlled degradation magnesium-based functional gradient material has good biocompatibility, bone inductivity, corrosion resistance and degradation controllability, and achieves the sequential degradation and controlled degradation of the magnesium alloy as a bone implanting material.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a controllable degradable magnesium-based functional gradient material and a preparation method thereof. Background technique [0002] The bone implant materials widely used clinically are mainly titanium alloy and stainless steel, but their implants cannot be absorbed and degraded in the body. When the injured bone heals, a second operation is required to remove it, which increases the physiological pain and economic burden of the patient. Therefore, more and more attention has been paid to replacing traditional medical metal materials with biomedical degradable materials. Magnesium alloy has good biodegradability and biocompatibility, and can be gradually degraded in the human body through corrosion. It is expected to become a new type of bone implant material. However, magnesium-based alloys used as implant materials have insufficient mechanical proper...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D9/12C22F1/06C23C26/00
CPCC22F1/06C23C26/00C25D9/12
Inventor 朱世杰雷少倩关绍康刘明明徐雪雪王利国王剑锋
Owner ZHENGZHOU UNIV
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