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A kind of α crystal form of motherwortine hydrochloride and its preparation method and application

A technology of Leonurine hydrochloride and crystal form, which is applied in the field of Leonurine hydrochloride alpha crystal form and preparation thereof, can solve problems such as no report on the crystal form of Leonurine hydrochloride, and achieve the effect of good stability

Active Publication Date: 2020-12-15
ANHUI NEW STAR PHARMA DEV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] However, there is no report on the crystal form research of leonurine hydrochloride

Method used

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  • A kind of α crystal form of motherwortine hydrochloride and its preparation method and application
  • A kind of α crystal form of motherwortine hydrochloride and its preparation method and application
  • A kind of α crystal form of motherwortine hydrochloride and its preparation method and application

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Embodiment 1

[0039] Embodiment 1 Preparation of Leonurine Hydrochloride Alpha Crystal Form

[0040] Add 10g of motherwortine hydrochloride into a 250mL round bottom flask, then add 90mL of purified water and 0.2g of activated carbon, heat to reflux for 30 minutes, filter while hot, cool the filtrate to 5°C at a rate of 2°C / min, and let it stand for 5h to precipitate crystals , after the crystallization was complete, filtered, the filtrate was recovered and used mechanically, the obtained crystals were combined, and dried under reduced pressure at 60° C. to obtain a white solid, which was the α-crystal form of motherwortine hydrochloride, with a weight of 8.4 g and a yield of 84%.

[0041] X-ray powder diffraction, infrared spectroscopy and DSC were used to characterize the α-crystal form of motherurine hydrochloride. The result is as Figure 1~3 and shown in Table 1.

[0042] The X-diffraction analysis data of table 1 motherurine hydrochloride α crystal form

[0043]

[0044]

[0...

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Abstract

The invention discloses a leonurine hydrochloride alpha crystal form, as well as a preparation method and application thereof. The crystal form has stronger diffraction peaks displayed in a powder X ray diffraction photograph expressed by a diffraction angle 2 theta as follows: 11.57 (100 percent), 12.44 (25 percent), 13.34 (16 percent), 16.85 (31 percent), 19.85 (16 percent), 21.35 (16 percent),22.31 (19 percent), 23.18 (37 percent), 24.50 (25 percent), 25.61 (67 percent), 26.36 (20 percent) and 30.14 (17 percent). The leonurine hydrochloride alpha crystal form prepared through the preparation method provided by the invention has the characteristic of good stability, can maintain stability under the conditions of high-illumination, high-temperature, high-humidity and long-time storage, and can be used for preparing a medicine composition.

Description

technical field [0001] The invention relates to the technical field of medicinal chemistry, in particular to a α crystal form of leonurine hydrochloride and a preparation method and application thereof. Background technique [0002] Motherwort is the fresh or dry aerial part of Motherwort (Leonurus Japonicus Houtt) of Labiatae. Bitter and slightly cold in nature, it returns to the liver and pericardium meridians; it has the effects of active blood stasis regulating, diuresis and swelling reduction, and is clinically used for the treatment of irregular menstruation, postpartum stasis, blood diseases, and cardiovascular and cerebrovascular diseases. It is known as "sacred medicine" and "good recipe for economic production". [0003] Leonurine (Leonurine) is one of the main active substances of Motherwort. It has significant effects of directly expanding peripheral blood vessels, increasing blood flow, and anti-platelet aggregation. It can effectively reduce blood viscosity an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C279/08C07C277/08A61K31/235A61K45/06A61P9/00A61P9/08A61P7/02A61P9/10A61P7/04A61P15/00
CPCA61K45/06C07B2200/13C07C277/08C07C279/08
Inventor 徐自奥李德刚李晓祥
Owner ANHUI NEW STAR PHARMA DEV
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