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Bifunctional collagen scaffold material, its preparation method and its application in spinal cord injury repair

A collagen scaffold, dual-function technology, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems of insufficient neuron differentiation, insufficient number of neural stem cells, etc., to reduce proliferation and promote the recovery of motor function.

Active Publication Date: 2021-03-16
DUBU BIOSCIENCES
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  • Description
  • Claims
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Problems solved by technology

However, the rapid proliferation of cells and functional biomolecules can lead to insufficient numbers of neural stem cells and insufficient neuronal differentiation at the site of spinal cord injury.

Method used

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  • Bifunctional collagen scaffold material, its preparation method and its application in spinal cord injury repair
  • Bifunctional collagen scaffold material, its preparation method and its application in spinal cord injury repair
  • Bifunctional collagen scaffold material, its preparation method and its application in spinal cord injury repair

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Embodiment Construction

[0047] In view of the shortcomings in the prior art, the inventors of the present invention have been used for long-term research and a large amount of practice, and the CBD-EGFR-Fab antibody with collagen-specific binding capacity is adsorbed on the neural regeneration bracket, and prepared a dual function collagen stent material. . The double functional collagen bracket material can be combined with exogenous neural stem cells to translate in the spinal cord full transverse part of the rat. Through in vitro and in vivo trials, the double functional collagen bracket material can bind exogenous neural stem cells to stay in damage zone and promote its differentiation to neurons. This has a good effect on the reconstruction of neuronal circuits after spinal cord injury, and the recovery of motion function can effectively solve the prior art transplantation neural stem cells in the treatment of spinal cord injury, exogenous neural stem cells from transplantation site diffusion and lo...

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Abstract

The invention discloses a dual-functional collagen scaffold material as well as a preparation method and an application thereof in spinal cord injury repair. The dual-functional collagen scaffold material consists of a nerve regeneration scaffold and a CBD-EGFR-Fab antibody which is bonded with the nerve regeneration scaffold, wherein the CBD-EGFR-Fab antibody comprises a collagen bonding area anda Fab area of an EGFR antibody which is linked to the collagen bonding area. According to the dual-functional collagen scaffold material provided by the invention, in vitro, exogenous neural stem cell bonding can be promoted and differentiation of inhibited neural stem cells towards neurons with the presence of myelin protein can be rescued, and in vivo, spread of the exogenous neural stem cellsfrom a transplantation site can be effectively relieved and a neuronal circuit can be reconstructed by promoting the differentiation of the neural stem cells towards functional neurons, so that the recovery of motor functions after spinal cord injury can be finally promoted.

Description

Technical field [0001] The present application relates to a bio-stent material, and more particularly to a dual functional collagen bracket material, a preparation method thereof, and an application in spinal cord injury. Background technique [0002] Spinal cord injury typically causes obstacles to permanent sensation and motion function below damage to the cross section. In recent years, there has been a huge progress in therapy based on neural stem cell treatment of spinal cord injury. Neural stem cells have a differentiated potential to neuron, astrocytes and less epitonal cells, and can self-renew, repair and replace nerve cells from spinal cord injuries. At the same time, neural stem cells are undifferentiated raw cells, and there is no mature cell antigen, which will not be identified by the host immune system after transplantation. In addition, it can also be integrated with the neuromic tissue of the host and survive in the host. However, small cells in the impairment in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/36A61L27/38A61L27/54
CPCA61L27/3604A61L27/3675A61L27/3834A61L27/3878A61L27/54A61L2300/256A61L2430/32
Inventor 戴建武赵燕南陈冰李晓然徐白
Owner DUBU BIOSCIENCES
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