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A kind of cream for treating infantile eczema and preparation method thereof

A technology for infant eczema and cream, applied in the directions of ointment delivery, pharmaceutical formula, emulsion delivery, etc., can solve problems such as skin irritation, and achieve the effect of easy absorption and suitable viscosity

Active Publication Date: 2019-07-23
江苏苏赋科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The current medicines for the treatment of eczema include antihistamines, corticosteroids, etc., and the treatment is prone to relatively large side effects; the common treatment method produces a large irritation to the skin, so it is necessary to develop a new type of eczema that is less irritating to the skin and has no toxic side effects. , effective and easy-to-use baby eczema cream

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1. Take 3 parts of stearic acid, 10 parts of polyethylene glycol-7-stearate, 12 parts of light liquid paraffin, 0.1 part of ethylparaben, and 0.8 part of vitamin E. Heat it in a water bath to 70-80 °C, Melt into a liquid to form an oil phase;

[0025] 2. Weigh 0.1 parts of edetate disodium, 5 parts of 1,2-propanediol, and 60 parts of deionized water, and heat in a water bath to 70-80°C to form the water phase;

[0026] 3. Weigh 2 parts of matrine and disperse in water to form matrine water;

[0027] 4. Slowly add the oil phase to the water phase while stirring. After adding the oil phase and continue to stir for 15 minutes, add matrine water when it is naturally cooled to below 40°C, continue to stir for 15 minutes, cool, and pack, that is have to.

Embodiment 2

[0029] 1. Take 5 parts of stearic acid, 12 parts of polyethylene glycol-7-stearate, 10 parts of light liquid paraffin, 0.1 part of ethylparaben, and 1.0 part of vitamin E. Heat it in a water bath to 70-80 ° C, Melt into a liquid to form an oil phase;

[0030] 2. Weigh 0.1 parts of disodium edetate, 5 parts of 1,2-propanediol, and 70 parts of deionized water, and heat in a water bath to 70-80°C to form the water phase;

[0031] 3. Weigh 2 parts of matrine and disperse in water to form matrine water;

[0032] 4. Slowly add the oil phase to the water phase while stirring. After adding the oil phase and continue to stir for 15 minutes, add matrine water when it is naturally cooled to below 40°C, continue to stir for 15 minutes, cool, and pack, that is have to.

Embodiment 3

[0033] Embodiment 3: thermal stability experiment

[0034] The infant eczema cream prepared in Example 1 or Example 2 was placed in a 55°C incubator for 24 hours, and it was found that the prepared cream remained uniform and stable without delamination. It shows that the infant eczema emulsifiable cream prepared by the patent of the present invention has thermal stability.

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PUM

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Abstract

The invention relates to the field of sanitizers, and provides cream for treating infant eczema and a preparation method thereof. The cream is mainly prepared from 3-5 parts of stearic acid, 8-12 parts of polyethylene glycol-7-stearate, 10-14 parts of light liquid paraffin, 0.08-0.12 part of ethylparaben, 0.8-1.5 parts of vitamin E, 0.08-0.12 part of edetate disodium, 4-6 parts of 1,2-propylene glycol, 1.5-2.5 parts of sophocarpidine and 60-70 parts of deionized water. The prepared cream for treating the infant eczema has the advantages of being uniform, fine, proper in viscosity and easy to absorb and has the advantages of eliminating inflammation, achieving sterilizing and causing no stimulation to skin; the cream is particularly suitable for infant eczema, and the total effective rate is 91.1%.

Description

technical field [0001] The invention relates to the technical field of disinfectants, in particular to an infant eczema cream and a preparation method thereof. Background technique [0002] Eczema is a common skin disease closely related to allergies caused by various internal and external factors. Clinically, it is often accompanied by itching of varying severity, various forms of skin lesions, and sometimes exudation and repeated attacks. Infant eczema is the most common in childhood, followed by childhood eczema. Most of the onset is 1 to 3 months after birth, and gradually alleviates after 6 months, and most children gradually recover spontaneously after 1 and a half years old. Part of the children delayed to infancy or childhood. The severity of the condition varies. The rash is more common on the head and face, such as the forehead, cheeks, and top of the head. At the beginning, it is scattered or clustered small red papules or erythema, which gradually increase, a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K47/06A61K47/10A61K47/12A61K47/14A61K31/4375A61K31/355A61P17/00A61P31/02
CPCA61K9/0014A61K9/06A61K31/355A61K31/4375A61K47/06A61K47/10A61K47/12A61K47/14A61K2300/00
Inventor 刘继勇钱丹顾永卫施倩倩顾清王婷
Owner 江苏苏赋科技发展有限公司
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