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Sodium alginate and preparation method and application of sodium alginate

A technology of sodium alginate and alginic acid, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, pill delivery, etc. It can solve the problems of large particle size distribution, large molecular weight distribution, unstable viscosity of sodium alginate, etc., and achieve particle size Narrow distribution, narrow molecular weight distribution, and stable sustained-release effect

Active Publication Date: 2018-06-22
QINGDAO BRIGHT MOON SEAWEED GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide a kind of sodium alginate and its preparation method and application, to solve the defects of existing sodium alginate viscosity instability, large molecular weight distribution, large particle size distribution

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0018] The preparation method of sodium alginate of the present invention comprises the steps:

[0019] (1) Soak and wash brown algae in water, mix and digest with alkaline agent, then dilute with water, add diatomaceous earth to filter, and then obtain alginic acid monomer through calcification;

[0020] (2) Degrade the alginic acid monomer at 30-50°C, and the degradation time is less than 2 hours;

[0021] (3) Use solid sodium carbonate as a neutralizer and alginic acid to mix and stir to obtain semi-finished sodium alginate, then stir with ethanol solution to disperse the semi-finished sodium alginate into powder, then granulate, dry, and pulverize to obtain sodium alginate .

[0022] In step (1), the brown algae include one or more of kelp, wakame, ascophyllum nodosum, sargassum and macroalgae, the soaking time is 3-15 hours, the water consumption is 3-6 times the quality of the brown algae, and the brown algae Adding water to soak and wash can remove impurity particles ...

Embodiment 1

[0039] The preparation method of the sodium alginate of the present embodiment comprises the steps:

[0040] (1) Soak and wash the kelp with water, and then mix it with sodium carbonate evenly. The soaking time is 10 hours, the amount of water is 6 times the mass of kelp, the amount of sodium carbonate is 40% of the mass of kelp, the digestion temperature is 54°C, and the digestion time is 5h; then add water to dilute, add diatomaceous earth to filter, and then obtain alginic acid monomer by calcium coagulation acidification method, the water content of alginic acid monomer is 70%;

[0041] (2) Degrade 600Kg of alginic acid monomer at 45°C for 1 hour;

[0042](3) Mix and react 54Kg of solid sodium carbonate with alginic acid for 30 minutes to obtain semi-finished sodium alginate, then add 20Kg of ethanol solution with a mass concentration of 80% and stir for 20 minutes to disperse the semi-finished sodium alginate into powder , then granulated, dried, pulverized, and passed t...

Embodiment 2

[0045] The preparation method of the sodium alginate of the present embodiment comprises the steps:

[0046] (1) Soak and wash macroalgae with water, and then mix them with sodium carbonate evenly. The soaking time is 10 hours. The time is 5 hours; then add water to dilute, add diatomaceous earth to filter, and then obtain alginic acid monomer through calcification acidification method, the water content of alginic acid monomer is 75%;

[0047] (2) Degrade 500Kg of alginic acid monomer at 45°C for 1 hour;

[0048] (3) Mix and react 45Kg of solid sodium carbonate with alginic acid for 30 minutes to obtain semi-finished sodium alginate, then add 20Kg of ethanol solution with a mass concentration of 80% and stir for 20 minutes to disperse the semi-finished sodium alginate into powder , then granulated, dried, pulverized, and passed through a 120-mesh sieve to obtain milky white sodium alginate.

[0049] The obtained sodium alginate has a viscosity of 350mpa.s, a viscosity decre...

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Abstract

The invention discloses sodium alginate and a preparation method and an application of the sodium alginate. The preparation method comprises the following steps: (1) soaking water to soak and wash brown algae, mixing and digesting with an alkaline agent, adding water to dilute, adding kieselguhr, filtering, and obtaining an alginic acid monomer according to a calcium coagulation acidification method; (2) degrading the alginic acid monomer at the temperature of 30-50 DEG C; (3) taking solid sodium carbonate as a neutralizer, mixing with the alginic acid, stirring, carrying out a reaction to obtain a semi-finished product of sodium alginate, then adding an ethanol solution, stirring to disperse the semi-finished product of sodium alginate into a powder, pelleting, drying and crushing to obtain the sodium alginate. The viscosity of the sodium alginate is 200-700 mpas, the viscosity drop rate is lower than 5%, the Mw / Mn is less than 1.85, the water content is less than 11%, the transparency is more than 30 cm, the specific gravity of a powder is 0.65-0.75 g / cm<3>, the granularity is 120 meshes, and the distribution of the powder granularity is narrow. The sodium alginate can be used ina slow release formulation, and the slow release effect is stable.

Description

technical field [0001] The invention relates to the technical field of sodium alginate for sustained-release preparations, in particular to a sodium alginate and its preparation method and application. Background technique [0002] Sodium alginate is used in tablets as a slow-release agent and binder, and forms an insoluble gel layer under acidic conditions to play a slow-release role. The viscosity (molecular weight) and gel strength (M / G) of sodium alginate, Powder characteristics affect the penetration effect of the gel layer. It is difficult to control the consistency of these factors in production, which leads to the problem of poor linear relationship between the dosage of sodium alginate and the release rate of tablets when used by pharmaceutical factories, which is not conducive to the adjustment of pharmaceutical factory formulations, and even Not available. [0003] The extraction process of sodium alginate is washing and soaking of brown algae, alkali digestion, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/04A61K9/22A61K47/36
CPCA61K9/205A61K47/36C08B37/0084
Inventor 王超杨照悦张德蒙徐泽斌张健王鹏
Owner QINGDAO BRIGHT MOON SEAWEED GROUP
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