50results about How to "Meet release requirements" patented technology

The present invention discloses a phenol-formaldehyde cyanate resin. It provides its chemical formula and synthesis method, and ablative composite material formed from the the above-mentioned phenol-formaldehyde cyanate resin.

The invention discloses pH response four-arm star block copolymer and a preparation method and application thereof. According to the copolymer, pentaerythritol is used as an inner core, each arm is connected with a hydrophobic group, a pH response group and a hydrophilic group; and the preparation method comprises the following steps of: performing ring opening polymerization on pentaerythritol to obtain hydrophobic group copolymer, performing acylation on the tail end of the hydrophobic group copolymer, and sequentially initiating pH response monomer and the hydrophilic group to perform electron transfer activating agent regeneration-atom transfer radical polymerization by using hydrophobic group copolymer of which the tail end is subjected to acylation and which is used as macroinitiator to obtain the pH response four-arm star block copolymer. The copolymer is self-assembled into nano micelle in an aqueous solution, so that insoluble medicines can be effectively solubilized; the copolymer is used for preparing a micelle medicine carrying system for insoluble anti-cancer medicines, and the medicines can be kept to be slowly released when pH of normal tissues is 7.4, and can be quickly released in a controllable way under the faintly acid condition that pH of cancer cells is 5 to 6; and the proportion of foundational groups of the copolymer is easy to control, and the copolymer is simple in synthesis process and high in yield.

The invention discloses a pH-responsive 6-arm star block copolymer and a preparation method and application thereof. In the structure of the copolymer, pentaerythritol is adopted as a kernel, and each arm is connected with a hydrophobic group, a pH-responsive group and a hydrophilic group. The preparation method comprises the steps of: carrying out ring opening polymerization of the pentaerythritol to obtain a hydrophobic group polymer, carrying out acylation of the end of the hydrophobic group polymer to prepare a macromolecular initiator, carrying out sequential initiation of regeneration of an electron transfer activator for a pH-responsive monomer and the hydrophilic group, i.e. radical polymerization for atom transfer, thereby obtaining the pH-responsive 6-arm star block copolymer. The polymer is self-assembled into nano micelles in aqueous solution, the dissolution of water-insoluble drugs can be enhanced effectively, the polymer can be applied in preparation of a micelle carrying system for water-insoluble anticancer drugs, and the drugs can be released slowly when the pH of normal tissues is 7.4 and rapidly in a controlled way under acidic conditions when the pH of tumor cells is 5-6; and the proportion of functional groups can be easily adjusted, the synthesis process is simple, and the yield is higher.

Belonging to the technical field of biomedical polymer materials, the invention discloses a beta-cyclodextrin based amphiphilic pH responsive star polymer and a preparation method thereof, a micelle system based thereon, a composite material and application thereof. The polymer has a structure shown as the formula (1) in the specification, wherein x=3-20, y=2-30, z=5-35, and n=2-10. The polymer can be reduced in situ to obtain nanogold with small particle size and good stability. The invention also provides a micelle system based on the polymer, the micelle system has strengthened entrapment ability to water-insoluble drugs, can efficiently load hydrophobic drugs, gold nanoparticles and other substances, realizes the combination of tumor imaging diagnosis and tumor chemotherapy, and improves the therapeutic efficiency of cancer. And the polymer is easy to control the proportion of each block, and can be applied to preparation of the water-insoluble drug loaded micelle system to satisfy the release requirements of different drugs.

The invention belongs to the technical field of preparation of biomedical high molecular polymer materials and discloses a cholesterol modified amphiphilic pH response pennicuius copolymer and a preparation method and a micelle system prepared based thereof. The copolymer has a structure shown in the formula I in the specification, wherein x is 10-36, y is 15-40 and z is 8-30. The copolymer is obtained by virtue of irregular copolymerization of a hydrophilic block hydroxyethyl methylacrylate, hydrophobic cholesterol and pH response block methacrylic acid N, N-diethyl aminoethyl combined with hydrophilic poly(ethylene glycol) methyl ether methacrylate. The copolymer is dissolved in a solvent to obtain a nanoscale micelle system, wherein the inner layer is a cholesterol modified hydrophobic chain segment, the middle layer is a pH response chain segment and the shell is a hydrophilic chain segment, so that the function of high entrapment performance, stable existence of a neutral condition and quick release in a weak acidic condition is achieved. By adjusting the proportions of the blocks in the polymer, the release rates of medicines can be regulated to satisfy the release requirements on different drugs.

The invention provides a pH and Redox dual-response amphiphilic block copolymer as well as a preparation method and application thereof. The molecular formula of the copolymer provided by the invention is MPEG-Linker-PAE-ss-PLGA and the copolymer has a structure as shown in the formula I and can be prepared through the following steps of performing reaction to modify macromonomer methoxypolyethylene glycols (MPEG), thereby obtaining hydrophilic macromonomer (MPEG-Linker) with pH responsiveness; performing reaction to modify macromonomer polylactic acid-poly lactic-co-glycolic acid (PLGA) by use of disulfide bonds, thereby obtaining a hydrophobic macromonomer (PLGA-Cys) with Redox responsiveness; and performing michael addition reaction through a one-step method so as to obtain the copolymer. The copolymer provided by the invention can be used in systems for loading water-insoluble drug micelle, is capable of controlling slow release of loaded drugs in normal tissues, is low in release amount accumulated for a long time, and can be enriched and rapidly released in focus tissues, thereby improving the bioavailability and treatment effect of the medicaments.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a medicament microsphere and a preparation method thereof. The medicament microsphere comprises medicinal materials, a high polymer material and a surfactant, wherein the ratio of the medicament to the high polymer material is 1:(1-3); the medicament preferably is celecoxib, ketoprofen, dipyridamole and nimodipine. The medicament microsphere is prepared by adopting an O / W emulsified solvent diffusion-volatilization method. The O / W emulsified solvent diffusion-volatilization method comprises the following steps: respectively weighing the medicinal materials, the high polymer material and a release regulator according to the prescription amount, and then adding the weighted materials to an organic solvent; ultrasonically or mechanically stirring and dissolving as a disperse phase; taking a surfactant solution as a continuous phase; warming and stirring after low-temperature emulsification under an agitation state, so as to remove an organic solvent; and then carrying out solid separation, washing by distilled water, and drying, so as to obtain the medicament microsphere. Thus, the prepared microsphere is high in encapsulation efficiency and high in yield.

The invention belongs to the technical field of biological medical macromolecule polymer materials, and discloses an amphipathic four-arm star-like polymer and a shell reversible crosslinked micelle system based on the same, and a preparation method and an application of the amphipathic four-arm star-like polymer. The polymer specifically has a structure shown by a formula (I) as shown in the specification, wherein x=10-30, y=5-20, and z=5-20. The invention also provides the shell reversible crosslinked micelle system based on the amphipathic four-arm star-like polymer. For the polymer disclosed by the invention, under the condition that the pH value is 6.5 and a catalyst namely aniline exists, an aldehyde group at a shell crosslinked site reacts with a crosslinking agent 3,3'-dithio-bis(propionic acid dihydrazide) to form a reversible crosslinked structure containing a disulfide bond and an acylhydrazone bond, and the reversible crosslinked structure has good stability and significantly-improved dilution resistance; and when the polymer is applied to loading water-insoluble medicines, controllable and rapid release of the water-insoluble medicines in different environments can be realized, efficient delivery release of medicines is realized, and the treatment efficiency of cancers is improved.

The invention relates to double-pH-response amphiphilic copolymer, the molecular formula of the double-pH-response amphiphilic copolymer is MPEG-Dliable-PAE-g-Chol, and the structure of the double-pH-response amphiphilic copolymer is as shown in formula I. The double-pH-response amphiphilic copolymer is copolymerized by hydrophilic block methoxy polyethylene glycol, hydrophobic cholesterol and pH response block poly(beta-amino ester). The double-pH-response amphiphilic copolymer has the advantages that the double-pH-response amphiphilic copolymer can self-assemble in an aqueous solution to obtain a nanoscale micellar system, the inner layer of the nanoscale micellar system is a hydrophobic core modified by cholesterol, the middle of the nanoscale micellar system is a pH-sensitive-response PAE layer, the shell of the nanoscale micellar system is hydrophilic block MPEG, the hydrophilic shell is connected sensitive middle layer through a pH-sensitive benzimide bond, the cell intake of a micelle drug-loading system is increased effectively while the requirements of high entrapment performance, stable system structure, long in-vivo circulation time, stability under neutral conditions and controllable drug release under weak acid conditions of hydrophobic drugs are satisfied, and accordingly drug bioavailability is increased, and a tumor treatment effect is optimized.

The invention belongs to the technical field of high molecular polymer materials for biomedicine, and discloses an amphiphilic pH-responsive 4 / 6 heteroarm star-shaped copolymer of which the number-average molecular weight is 30000-54000g / mol. The invention also discloses a preparation method of the amphiphilic pH-responsive 4 / 6 heteroarm star-shaped copolymer, which comprises the following steps: mixing epsilon-caprolactone, stannous octoate and low molecular initiator, reacting at 110-140 DEG C for 24-48 hours, performing reduced pressure distillation, precipitating, filtering, and drying to obtain polycaprolactone high molecular initiator; dissolving the polycaprolactone high molecular initiator, 2-diethylaminoethyl methacrylate, hexamethyltriethylenetetramine and copper bromide in toluene, stirring, then adding stannous octoate, and reacting at 60-90 DEG C for 5-12 hours; and adding methoxy polyoxyethylene methacrylate, continuously polymerizing for 5-12 hours, removing a catalyst, filtering, and performing posttreatment on the filtrate to obtain the amphiphilic pH-responsive 4 / 6 heteroarm star-shaped copolymer. The amphiphilic pH-responsive 4 / 6 heteroarm star-shaped copolymer is used for preparation of a micelle system for carrying water insoluble medicaments.

The invention discloses a potential of hydrogen (pH) response random copolymer based on poly-beta amino ester and a preparation method and application thereof. Firstly, polylactic acid with two ends sealed with hydroxide radicals is synthesized through a solution polymerization method, propylene serves as a macro-monomer after acidification, and a pH response amphiphilic copolymer is prepared through the Michael gradual addition reaction. The proportion of functional groups in the polymer molecule can be regulated. The synthetic process is simple, and the production rate is high. By means of a polymeric micelle obtained through a dialysis method and with a hydrophobic group (polylactic acid) and a pH response group (poly-beta amino ester) forming a kernel and a hydrophilic group forming acasing, water slight-solubility anti-cancer drugs can be coated into the kernel of the micelle, and the drugs can be slowly released in low quantity under neutral or weak alkaline conditions and can be quickly and controllably released under weakly acidic conditions.

The invention discloses a pH response / membrane adhesive amphiphilic block copolymer as well as a preparation method and application thereof. According to the preparation method, methacrylic acid with an isoelectric point of 5.0-6.5 is utilized as a pH response monomer, methacrylic aminoethyl ester with pH-insensitive hydrophilia is utilized as a membrane-adhesive monomer, an electron transfer activator regeneration-atom transfer free radical active polymerization method is adopted, a pH response monomer and hydrophobic monomer block copolymer is firstly prepared; and by taking the pH response monomer and hydrophobic monomer block copolymer as a macroinitiator, the membrane-adhesive monomer, namely the methacrylic aminoethyl ester is polymerized, and finally acidolysis reaction is performed, so that the pH response / membrane adhesive amphiphilic block copolymer is prepared. The pH response / membrane adhesive amphiphilic block copolymer is capable of being self-assembled to form a core-shell structure micelle in an aqueous solution, has favorable pH sensibility and membrane adhesion property, lower critical micelle concentration and relaively small micelle particle size, and can be used in drug delivery systems for oral medication application of polypeptide or proteinic drugs.

The invention relates to a water-soluble polymer coated agent, a coated controlled release fertilizer that contains a coated agent and a preparation method thereof. The water-soluble polymer coated agent of the invention is characterized in that the coated agent contains alkyd resin prepolymer in a way of neutralization. The coated controlled release fertilizer of the invention consists of a fertilizer core and a capsule which is outside the fertilizer core; wherein, the capsule contains a polymer film that contains the water-soluble polymer coated agent of the invention, and an inorganic layer that is arbitrarily arranged on the polymer film and contains inorganic powders.

The invention relates to a novel long-acting sustained-release preparation and a preparation method thereof, in particular to a matrix sustained-release tablet with a controlled retardant layer and a preparation method thereof. The invention enables the matrix sustained-release tablet to be changed from the traditional single-layer tablet core structure to a double-layer structure including a drug containing layer and the controlled retardant layer by adding the controlled retardant layer to the structure of the traditional matrix sustained-release tablet, can also control the time of the retardant layer playing a retardant role by controlling the dissolving or corroding time of the retardant layer through predesign, very efficiently control the drug release and reduce the burst release and the late residuals, thereby obtaining excellent release effect.

The invention belongs to the technical field of high-molecular polymer materials for biological medicines, and discloses a cholesterol modification based pH response polypeptide polymer as well as a preparation method and application thereof. The polypeptide polymer has a structure shown in a formula (1): mPEG-R-Chol (1). The polypeptide polymer disclosed by the invention is a polypeptide pH response amphiphilic tri-block polymer material which is hydrophilically modified by methoxy polyethylene glycol and is hydrophobically modified by cholesterol, can be self-assembled to be nano-micelles in an aqueous solution, can be used for effectively encapsulating water-insoluble medicines, can be applied to the field of medicines, and is particularly suitable for preparing a targeted medicine delivery system of water-insoluble anti-cancer medicines. Moreover, the polypeptide polymer is adjustable and controllable in topological structure and simple in synthesis process, and can be used for adjusting and controlling the release rate of the medicines by adjusting the content of polypeptide with pH response so as to ensure that the release requirements of different medicines can be met. The polypeptide polymer disclosed by the invention has relatively low critical aggregation concentration, and the critical aggregation concentration is only 1.8-4.8mg / L, so that high stability of the medicine delivery micelles can be achieved.

The invention discloses an amphipathic tri-block copolymer having pH responsiveness and a preparation method of same, wherein the amphipathic tri-block copolymer is in a linear structure and is composed of functional polymethyl methacrylate (PMMA), polymethylacrylic acid (PMAA) and polymethylacryloxyethyltrimethyl ammonium chloride (PDMC), number-average molecular weight being 4000-13000 g / mol. Ina water solution, the copolymer can be self-assembled to form spherical micelle which has a hydrophobic inner layer and a hydrophilic outer layer. The copolymer has high pH responsiveness, small micelle particle size and low critical micelle concentration, and is suitable for coating a hydrophobic drug as a carrier in the fields of targeted transmission and controllable sustained release.

The invention provides a phenolic cyanate resin ablator composed by mixture of alloied linear phenolic cyanate resin and linear fused ring phenolic cyanate resin and strengthen material which can satisfy the demand of high corbon residu ratio (>60 percent), high heat-resistance temp. (>350 deg.C), low fusant viscosity, low solidify agravity ratio and long gel time.

The invention discloses an easily degradable response type core-crosslinkable amphiphilic block polymer, a preparation method thereof and an application of the amphiphilic block polymer as a drug carrier. According to the amphiphilic block polymer, methoxypolyethylene glycol-b-polylactide serves as a main chain, and a side chain is modified with carboxyl and a dithiopyridine group; the amphiphilic block polymer and a water-insoluble drug can easily form a response type core cross-linked micelle, and the micelle is stable in a normal physiological environment, and is easy to be stimulated by environment after reaching tumour cells, and then, the cross-linked structure is damaged, so that the controlled release of the medicine is realized, the utilization rate of the medicine is improved, and the toxic and side effects of the loaded medicine are reduced; theamphiphilic block polymer is easy to degrade, so thatlong-term toxicity caused by accumulation of micelles in human tissues and organs is avoided; the amphiphilic block polymer has goodbiocompatibility, and has wide potential application prospects in the field of cancer chemotherapy; and the synthetic method of the amphiphilic block polymer is simple, mild in condition, few in side reaction and beneficial to expanded production.

The invention discloses a sustained release preparation of which the active components comprise methoxyphenamine or hydrochloride thereof, narcotine, aminophylline and chlorphenamine maleate, wherein the ratio of the active components to sustained release auxiliary materials is 1:0.03 to 1:30, preferably 1:0.05 to 1:16, more preferably 1:0.08 to 1:10, and the drug is controlled to continuously release for 12-24 hours. The compound sustained release preparation comprises tablets, capsules and suspension.

The invention relates to an accumulative and free conveying device with adjustable load and its driving device, which includes a motor and a transmission shaft, and is characterized in that it also includes a bearing, a friction block, a sprocket bearing, a sprocket, a locking pin, a spring and a lock A lock nut, the bearing, the friction block, the sprocket bearing, the sprocket, the locking pin, the spring and the lock nut are installed and integrated on the transmission shaft. The accumulative and free conveying equipment is also provided with a workpiece release button and a workpiece blocking block. The workpiece blocking block blocks the workpiece at a single station for assembly. When the blocking force of the workpiece blocking block is greater When the transmission force between the wheels, the workpiece stops flowing into the next station to meet the needs of the assembly line accumulation; when the release button is activated, the workpiece blocking block stops blocking the workpiece, and the workpiece flows into the next station. The invention has the advantages of simple structure and low cost, and scientifically improves the efficiency of personnel assembly while satisfying the driving and accumulating requirements of the production line.

The invention discloses sodium alginate and a preparation method and an application of the sodium alginate. The preparation method comprises the following steps: (1) soaking water to soak and wash brown algae, mixing and digesting with an alkaline agent, adding water to dilute, adding kieselguhr, filtering, and obtaining an alginic acid monomer according to a calcium coagulation acidification method; (2) degrading the alginic acid monomer at the temperature of 30-50 DEG C; (3) taking solid sodium carbonate as a neutralizer, mixing with the alginic acid, stirring, carrying out a reaction to obtain a semi-finished product of sodium alginate, then adding an ethanol solution, stirring to disperse the semi-finished product of sodium alginate into a powder, pelleting, drying and crushing to obtain the sodium alginate. The viscosity of the sodium alginate is 200-700 mpas, the viscosity drop rate is lower than 5%, the Mw / Mn is less than 1.85, the water content is less than 11%, the transparency is more than 30 cm, the specific gravity of a powder is 0.65-0.75 g / cm<3>, the granularity is 120 meshes, and the distribution of the powder granularity is narrow. The sodium alginate can be used ina slow release formulation, and the slow release effect is stable.

The invention aims at providing an anti-depression slow-release capsule which is simple in preparation process, low in cost, small in pollution and high in safety. The slow-release capsule is formed by a drug-containing pill core, an isolating layer and a slow-release layer. The preparation method comprises the steps of adopting an extruding rounding method to prepare the drug-containing pill core, then coating a coating solution with the pill core together in a fluidized bed and drying to prepare the slow-release pellet. The prepared anti-depression slow-release pellet is further prepared into common capsules, and after being taken, the hold time of the effective blood concentration in the body is long and the adverse reaction is reduced. According to the invention, ethyl cellulose aqueous dispersion is adopted as the coating solution of the slow-release layer, plasticizer and antisticking agent are not needed to be added, the preparation method is simple and convenient, an organic solvent is not used in coating, the operation is simple and convenient, the cost is low, the safety is good, and no organic residue exists in the coating pellet, thereby effectively solving the problems of heavy pollution and low safety in coating of the organic solvent.

The invention belongs to the technical field of hydraulic control and specifically relates to an energy accumulator liquid filling integrated valve. The energy accumulator liquid filling integrated valve comprises a flow priority valve, a liquid filling valve and an electromagnetic switching valve set. The flow priority valve comprises a three-position four-way valve and a damping II. An oil inletof the three-position four-way valve is connected with an oil port P. The liquid filling valve comprises a one-way valve, a two-position two-way valve I, an overflow valve and an adjustable throttling valve II. An oil port A of the three-position four-way valve communicates with an oil inlet of the one-way valve. An oil outlet of the one-way valve is connected with an oil port P3. The oil port Pis connected with an oil inlet of the two-position two-way valve I through the damping II. An oil outlet of the two-position two-way valve I is connected with an oil port T1. A spring cavity of the three-position four-way valve is connected with an oil inlet of the two-position two-way valve I. The overflow valve and the adjustable throttling valve II are connected between the oil port T1 and theoil port P3 in parallel. An oil port B of the three-position four-way valve is connected with an oil port P1. Through the integrated flow priority valve of the energy accumulator liquid filling integrated valve, switching and synchronous operating of an energy accumulator and a tamping device main valve can be realized.

The invention belongs to the technical field of medicines, and particularly discloses a ginkgo leaf total flavone controlled-release tablet and a preparation method thereof. The controlled-release tablet disclosed by the invention is a tablet which is prepared by combining polyoxyethylene and a controlled-release skeleton material and adopting a conventional tablet preparation technology and has the zero-order release behavior characteristic. The controlled-release tablet consists of an active ingredient ginkgo leaf total flavone, a high polymer material polyoxyethylene (PEO), the controlled-release skeleton material and a certain amount of release rate conditioning agent. The active ingredients of the ginkgo leaf total flavone mainly comprise isorhamnetin, kaempferide and quercetin, and the total flavonoid glycoside content of the quercetin is not lower than 20%. Compared with a common tablet, the ginkgo leaf total flavone controlled-release tablet has the advantages that the controlled-release tablet can be used for maintaining the constancy of the blood concentration, reducing the adverse reactions of the medicines and improving the compliance of the patients. The preparation method is simple in technological operation, low in cost, easy to control and suitable for industrial large-scale production.

The invention discloses a phenolic cyanate resin ablation material, which is composed of a blend obtained by blending a linear phenolic cyanate resin and a linear condensed ring phenolic cyanate resin and a reinforcing material. The blended phenolic cyanate can simultaneously meet the characteristics of high carbon residue rate (>60%), high heat resistance temperature (>350°C), low melt viscosity, low curing weight loss rate, long gel time, etc., and can meet Ablation performance requirements for high carbon residue rate and injection process requirements.

The invention belongs to the technical field of high-molecular polymer materials for biological medicines, and discloses a cholesterol modification based pH response polypeptide polymer as well as a preparation method and application thereof. The polypeptide polymer has a structure shown in a formula (1): mPEG-R-Chol (1). The polypeptide polymer disclosed by the invention is a polypeptide pH response amphiphilic tri-block polymer material which is hydrophilically modified by methoxy polyethylene glycol and is hydrophobically modified by cholesterol, can be self-assembled to be nano-micelles in an aqueous solution, can be used for effectively encapsulating water-insoluble medicines, can be applied to the field of medicines, and is particularly suitable for preparing a targeted medicine delivery system of water-insoluble anti-cancer medicines. Moreover, the polypeptide polymer is adjustable and controllable in topological structure and simple in synthesis process, and can be used for adjusting and controlling the release rate of the medicines by adjusting the content of polypeptide with pH response so as to ensure that the release requirements of different medicines can be met. The polypeptide polymer disclosed by the invention has relatively low critical aggregation concentration, and the critical aggregation concentration is only 1.8-4.8mg / L, so that high stability of the medicine delivery micelles can be achieved.

The invention discloses a pH-responsive 6-arm star block copolymer and a preparation method and application thereof. In the structure of the copolymer, pentaerythritol is adopted as a kernel, and each arm is connected with a hydrophobic group, a pH-responsive group and a hydrophilic group. The preparation method comprises the steps of: carrying out ring opening polymerization of the pentaerythritol to obtain a hydrophobic group polymer, carrying out acylation of the end of the hydrophobic group polymer to prepare a macromolecular initiator, carrying out sequential initiation of regeneration of an electron transfer activator for a pH-responsive monomer and the hydrophilic group, i.e. radical polymerization for atom transfer, thereby obtaining the pH-responsive 6-arm star block copolymer. The polymer is self-assembled into nano micelles in aqueous solution, the dissolution of water-insoluble drugs can be enhanced effectively, the polymer can be applied in preparation of a micelle carrying system for water-insoluble anticancer drugs, and the drugs can be released slowly when the pH of normal tissues is 7.4 and rapidly in a controlled way under acidic conditions when the pH of tumor cells is 5-6; and the proportion of functional groups can be easily adjusted, the synthesis process is simple, and the yield is higher.