Potential of hydrogen (pH) response random copolymer based on poly-beta amino ester and preparation method and application thereof
A technology of random copolymers and amino esters, which is applied in the direction of medical preparations of non-active ingredients, drug combinations, antineoplastic drugs, etc., can solve the problems of drug side effects, slow process, and aggravated burst release, and achieve high load The effect of the dose
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[0091] Example 1
[0092] (1) Synthesis of HO-PLA-OH (A:B:C=100:5:1, A represents monomer lactide, B represents initiator 1,4-butanediol, C represents catalyst Sn(Oct) 2 , The ratio is the mass percentage, the same below). Add a stir bar and monomer lactide (20 g, 93.9 parts) into a 100 mL reaction flask with a stir bar, seal and vent-vent three times. Under the protection of argon, add the solvent toluene (40 mL) with a syringe. ) And catalyst Sn(Oct) 2 (0.3 mg, 1.41 parts) and the initiator 1,4-butanediol (1 g, 4.69 parts). After freezing with liquid nitrogen, vacuum-heat-inflate three times, and react for 24 h in an oil bath at 100 ℃ under the protection of argon. After the reaction is completed, the resulting solution is rotary evaporated under reduced pressure to remove toluene, and then the polymer is dissolved in chloroform to obtain a solution, which is slowly added to 300 mL (equivalent to 10 times the volume of the solution) of frozen methanol / water (1:1, v / v), afte...
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[0097] Example 2
[0098] (1) Synthesis of HO-PLA-OH (A:B:C=100:15:3, A represents monomer lactide, B represents initiator 1,4-butanediol, C represents catalyst Sn(Oct) 2 , The ratio is the mass percentage, the same below). Add a stir bar and monomer lactide (10 g, 91.32 parts) into a 100 mL reaction flask with a stir bar, seal and ventilate three times. Under the protection of argon, add the solvent toluene (40 mL) with a syringe. ) And catalyst Sn(Oct) 2 (0.15 mg, 1.37 parts) and the initiator 1,4-butanediol (0.8 g, 7.31 parts). After freezing with liquid nitrogen, vacuum-heat-inflate three times, and react in an oil bath at 95 ℃ for 30 h under argon protection. After the reaction is completed, the resulting solution is rotary evaporated under reduced pressure to remove toluene, and then the polymer is dissolved in chloroform to obtain a solution, which is slowly added to 300 mL (equivalent to 10 times the volume of the solution) of frozen methanol / water (1:1, v / v), after w...
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[0102] Example 3
[0103] (1) Synthesis of HO-PLA-OH (A:B:C=300:5:1, A represents monomer lactide, B represents initiator 1,4-butanediol, C represents catalyst Sn(Oct) 2 , The ratio is the mass percentage, the same below). Add a stir bar and monomer lactide (30 g, 98.04 parts) into a 100 mL reaction flask with a stir bar, seal and vent-vent three times. Under the protection of argon, add the solvent toluene (40 mL) with a syringe. ) And catalyst Sn(Oct) 2 (0.1 mg, 0.33 parts) and the initiator 1,4-butanediol (0.5 g, 1.63 parts). After freezing with liquid nitrogen, vacuum-heat-inflate three times, and react in an oil bath at 105 ℃ for 20 h under the protection of argon. After the reaction is completed, the resulting solution is rotary evaporated under reduced pressure to remove toluene, and then the polymer is dissolved in chloroform to obtain a solution, which is slowly added to 300 mL (equivalent to 10 times the volume of the solution) of frozen methanol / water (1:1, v / v), a...
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