Novel matrix sustained-release tablet and preparation method thereof

A skeleton slow-release material and slow-release tablet technology, applied in the field of medicine, can solve the problems of accelerated drug release, slow release rate, single release mechanism, etc., and achieve the effect of increasing the release rate and uniform drug release rate
CN101933907AInactive Publication Date: 2011-01-05北京天衡药物研究院有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
北京天衡药物研究院有限公司
Publication Date
2011-01-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a novel long-acting sustained-release preparation and a preparation method thereof, in particular to a matrix sustained-release tablet with a controlled retardant layer and a preparation method thereof. The invention enables the matrix sustained-release tablet to be changed from the traditional single-layer tablet core structure to a double-layer structure including a drug containing layer and the controlled retardant layer by adding the controlled retardant layer to the structure of the traditional matrix sustained-release tablet, can also control the time of the retardant layer playing a retardant role by controlling the dissolving or corroding time of the retardant layer through predesign, very efficiently control the drug release and reduce the burst release and the late residuals, thereby obtaining excellent release effect.
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Description

Technical field

[0001] The invention belongs to the field of medicine, and relates to a novel matrix sustained-release tablet, in particular to a matrix sustained-release tablet with a controllable retardation layer. Background technique

[0002] After nearly 50 years of development, oral drug sustained-release and controlled-release pharmaceutical preparations have become an important direction for the development of domestic and foreign pharmaceutical products. At present, there are more than 200 varieties of such preparations on the market abroad with more than 500 specifications. In 2008, the global market for oral sustained and controlled release preparations exceeded US$30 billion.

[0003] The preferred dosage form of sustained-release pharmaceutical preparations is tablets. At present, the most widely used in the world is the use of hydrophilic gel matrix tableting technology to make hydrophilic gel matrix tablets. When producing such sustained-release tablets, the activ...

Claims

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