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Ginkgo leaf total flavone controlled-release tablet and preparation method thereof
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A technology of total flavonoids and ginkgo leaves, which is applied in the field of controlled-release tablets and preparation of total flavonoids from ginkgo leaves, which can solve the problems of cumbersome coating of controlled-release tablets and adverse health effects
Inactive Publication Date: 2014-02-26
SHENYANG PHARMA UNIVERSITY
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However, the coating of the controlled-release tablet is relatively cumbersome, and the coatingsolvent is an organic solvent, which is harmful to health
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[0041] Pass the total flavonoids of Ginkgo biloba leaves, polyoxyethylene, methylcellulose, and lactose through 80-mesh sieves (grind first if necessary), weigh each excipient according to the prescription amount, mix them with total flavonoids of Ginkgo biloba leaves, and press into tablets. have to.
[0051] Pass the total flavonoids of Ginkgo biloba leaves, polyoxyethylene, carbomer, and microcrystallinecellulose through an 80-mesh sieve (grind first if necessary), weigh each auxiliary material and total flavonoids of Ginkgo biloba leaves according to the prescription amount, and use the method of equal addition Mix evenly, then add absolute ethanol to granulate, dry at 45°C for 12 hours, add magnesiumstearate, mix evenly, and press into tablets to obtain.
[0061] Pass the total flavonoids of Ginkgo biloba leaves, polyoxyethylene, hydroxypropyl cellulose, and microcrystallinecellulose through 80-mesh sieves (if necessary, grind them first), weigh each auxiliary material and total flavonoids of Ginkgo biloba leaves according to the prescription amount, and weigh Mix by incremental method, then add 90% ethanol to granulate, dry at 45°C for 12 hours, add magnesiumstearate, mix evenly, and press into tablets.
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Abstract
The invention belongs to the technical field of medicines, and particularly discloses a ginkgo leaf total flavone controlled-release tablet and a preparation method thereof. The controlled-release tablet disclosed by the invention is a tablet which is prepared by combining polyoxyethylene and a controlled-release skeleton material and adopting a conventional tablet preparation technology and has the zero-order release behavior characteristic. The controlled-release tablet consists of an active ingredientginkgo leaf total flavone, a high polymer material polyoxyethylene (PEO), the controlled-release skeleton material and a certain amount of release rate conditioning agent. The active ingredients of the ginkgo leaf total flavone mainly comprise isorhamnetin, kaempferide and quercetin, and the total flavonoidglycoside content of the quercetin is not lower than 20%. Compared with a common tablet, the ginkgo leaf total flavone controlled-release tablet has the advantages that the controlled-release tablet can be used for maintaining the constancy of the blood concentration, reducing the adverse reactions of the medicines and improving the compliance of the patients. The preparation method is simple in technological operation, low in cost, easy to control and suitable for industrial large-scale production.
Description
technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a ginkgo leaf total flavonoids controlled-release tablet and a preparation method. Background technique [0002] The total flavonoids of Ginkgo biloba is Ginkgo biloba extract, with a content of more than 20%. It mainly contains some flavonoids and flavonoid glycosides, including quercetin, isorhamnetin, and kaempferins. Pharmacological studies have shown that the total flavonoids in Ginkgo biloba can increase cerebrovascular flow, improve cerebrovascular circulation, protect brain cells, expand coronary arteries, prevent angina pectoris and myocardial infarction, prevent thrombosis, and improve the body's immunity. It is very beneficial to patients with coronary heart disease, angina pectoris, cerebral arteriosclerosis, senile dementia, and hypertension. [0003] At present, there are Chinese patentmedicine preparations using the total flavonoids of Ginkg...
Claims
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