Compound methoxyphenamine sustained release preparation

A technology for methoxyphenamine and sustained-release preparations, which is applied to medical preparations containing no active ingredients, medical preparations containing active ingredients, and pill delivery, etc. Methoxyphenamine products do not have problems such as sustained release

Active Publication Date: 2011-10-12
SALUS PHARMA TECH SHANGHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chinese patent 200410065967.4 discloses a preparation method for oral solid preparations containing methoxypheniramine, narcotine, aminophylline, and chlorpheniramine maleate. The compound methoxyphenamine product obtained by this method does not have sustained release release effect
According to the existing methods of taking medicines on the market, not only the dosage is relatively large, but also the number of takings is many, which is not conducive to ensuring that patients take medicine on time

Method used

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  • Compound methoxyphenamine sustained release preparation
  • Compound methoxyphenamine sustained release preparation
  • Compound methoxyphenamine sustained release preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] Example 1: Compound tablet with sustained release up to 12 hours

[0094]

[0095] Preparation Process:

[0096] According to the proportion of the above formula, the active ingredients (methoxamine, noscapine, aminophylline, chlorpheniramine maleate) are mixed with hydroxypropyl methylcellulose and xanthan gum and stirred evenly; add an appropriate amount of The ethanol solution is stirred into fine particles and dried; pulverized to make them all pass through the No. 2 sieve of the Chinese Pharmacopoeia; the pulverized particles are added with filler microcrystalline cellulose and lubricant magnesium stearate, and compressed into tablets;

Embodiment 2

[0097] Example 2: Compound tablet with sustained release up to 24 hours

[0098]

[0099]

[0100] Preparation Process:

[0101] According to the ratio of the above-mentioned formula amount, the active ingredients (methoxyphenamine, noscapine, aminophylline, chlorpheniramine maleate) are mixed with hydroxypropyl methylcellulose and sodium alginate and stirred evenly; add an appropriate amount of The ethanol solution is stirred into fine particles and dried; pulverized to make them all pass through the No. 2 sieve of the Chinese Pharmacopoeia; the pulverized particles are added with filler microcrystalline cellulose and lubricant magnesium stearate, and compressed into tablets;

Embodiment 3

[0102] Example 3: Compound capsules with sustained release up to 12 hours

[0103]

[0104] Preparation Process:

[0105] The active ingredients (Methoxamine, Noscapine, Aminophylline, Chlorpheniramine Maleate), polyethylene glycol, sodium alginate and filler microcrystalline cellulose are mixed and stirred according to the above formula amounts Evenly; add an appropriate amount of aqueous solution, use an extrusion spheronizer to form pellets with a diameter of about 1.0mm, dry them, and put them into capsules;

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Abstract

The invention discloses a sustained release preparation of which the active components comprise methoxyphenamine or hydrochloride thereof, narcotine, aminophylline and chlorphenamine maleate, wherein the ratio of the active components to sustained release auxiliary materials is 1:0.03 to 1:30, preferably 1:0.05 to 1:16, more preferably 1:0.08 to 1:10, and the drug is controlled to continuously release for 12-24 hours. The compound sustained release preparation comprises tablets, capsules and suspension.

Description

technical field [0001] The invention relates to a compound sustained-release preparation containing methoxnamin or its hydrochloride, noscapine, aminophylline, and chlorpheniramine maleate, which can be continuously released for 12 to 24 hours. Background technique [0002] Compound methoxyphenamine is an anti-asthma drug used for bronchial asthma and asthmatic bronchitis. Methoxynamine or its hydrochloride salt inhibits bronchospasm and relieves cough during asthma attacks. Nacodin is a peripheral cough suppressant that suppresses cough. Aminophylline can also inhibit bronchospasm, and can inhibit the swelling of bronchial mucosa, relieve cough during asthma attack, and make phlegm easy to cough up. Chlorpheniramine maleate has antihistamine properties. The compatibility of this product can not only relieve cough caused by throat and bronchial inflammation, but also relieve cough during asthma attack, which is beneficial to expectoration. At present, the taking method o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/522A61K31/137A61K31/4741A61K31/4402A61K9/22A61K9/52A61K9/10A61P11/06A61P11/14
CPCA61K9/0095A61K9/1652A61K9/205A61K9/2054A61K9/5042A61K31/137A61K31/4402A61K31/4741A61K31/522A61K47/36A61K47/38A61P11/06A61P11/14
Inventor 田武王诺郑礼亮
Owner SALUS PHARMA TECH SHANGHAI
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