Application of long-chain non-coding RNA and composition thereof to diagnosis and treatment of cancer of biliary duct

A long-chain non-coding and composition technology, applied to long-chain non-coding RNA, the application in the preparation and diagnosis of cholangiocarcinoma and target drug therapy, and the application field in the preparation of reagents for diagnosing cholangiocarcinoma, which can solve the poor prognosis of cholangiocarcinoma patients , malignant progression of cholangiocarcinoma, etc.

Inactive Publication Date: 2018-06-29
THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Although there are currently clinical treatments such as surgery, radiotherapy, and chemotherapy, the prognosis of patients with cholangiocarcinoma is still poor
Studies have shown that the abnormal expression of lncRNAs mediates the malignant progression of cholangiocarcinoma

Method used

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  • Application of long-chain non-coding RNA and composition thereof to diagnosis and treatment of cancer of biliary duct
  • Application of long-chain non-coding RNA and composition thereof to diagnosis and treatment of cancer of biliary duct
  • Application of long-chain non-coding RNA and composition thereof to diagnosis and treatment of cancer of biliary duct

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Embodiment Construction

[0070] The present invention is further illustrated below with examples, but the present invention is not limited thereto. For the experimental methods without specific conditions indicated in the following examples, the conventional conditions or the conditions suggested by the manufacturer are usually followed.

[0071] 1. Bioinformatics screening and identification of high expression of PVT1 in cholangiocarcinoma

[0072] (1) The inclusion criteria entered the GEO database ( http: / / www.ncbi.nlm.nih.gov / gds), Query "cholangiocarcinoma" and "cancer of biliary duct", limit the filter conditions "Entry type: Series", "Organism: Homo sapiens", "Study type: Expression profiling by array" and "Attribute name: tissue", get information about cholangiocarcinoma According to the results of microarray research query, select research projects that meet the following requirements: cholangiocarcinoma, case-control (or cancer-adjacent), mainstream microarray platforms (Affy, Agilent, and...

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Abstract

The invention belongs to the field of genetic engineering, and particularly relates to application of long-chain non-coding RNA and composition thereof to diagnosis and treatment of cancer of biliaryduct. Meanwhile, the invention further relates to application of a primer thereof to preparation of a reagent for diagnosing colon cancer. By studying the expression of the long-chain non-coding RNA cell, the relationship between the long-chain non-coding RNA and the pathogenesis of cancer of biliary duct is revealed.

Description

technical field [0001] The invention belongs to the field of genetic engineering, and particularly relates to a long-chain non-coding RNA, PVT and its composition, and its application in the preparation and diagnosis of cholangiocarcinoma and target drug treatment. Simultaneously, the present invention also relates to the application of its primers in the preparation of reagents for diagnosing cholangiocarcinoma. By studying the expression of the long non-coding RNA at the cellular level, the relationship between it and the pathogenesis of cholangiocarcinoma was revealed. Background technique [0002] Tumor is a major culprit that seriously threatens human health, and the research on the molecular mechanism of tumor malignant progression has always been the focus and difficulty of the academic circle. It has been reported that tumor cells have cell phenotype characteristics such as promoting proliferation, invasion and metastasis, continuous angiogenesis, immune tolerance a...

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/113C12N15/11A61K31/7088A61P35/00
CPCA61K31/7088C12Q1/6886C12Q2600/118C12Q2600/158C12Q2600/178
Inventor 缪林于洋季国忠李全朋葛贤秀王飞张秀华
Owner THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIV
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