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Manufacturing method of amorphous alloy microneedle

A manufacturing method and technology of amorphous alloys, applied in the direction of manufacturing tools, metal processing equipment, laser welding equipment, etc.

Active Publication Date: 2018-07-03
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There have been no reports of skin infections caused by the use of microneedles, studies have shown that MN can be inserted into the skin without additional applicator devices

Method used

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  • Manufacturing method of amorphous alloy microneedle
  • Manufacturing method of amorphous alloy microneedle
  • Manufacturing method of amorphous alloy microneedle

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Embodiment Construction

[0036] Embodiments of the present invention are described below through specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific implementation modes, and various modifications or changes can be made to the details in this specification based on different viewpoints and applications without departing from the spirit of the present invention.

[0037] It should be noted that the diagrams provided in this embodiment are only schematically illustrating the basic idea of ​​the present invention, and only the components related to the present invention are shown in the diagrams rather than the number, shape and shape of the components in actual implementation. Dimensional drawing, the type, quantity and proportion of each component can be changed arbitrarily during actual impleme...

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Abstract

The invention provides an amorphous alloy microneedle and a manufacturing method thereof. The manufacturing method comprises the following steps: manufacturing a microneedle forming silicon mold on asilicon wafer by employing a micro-nano machining technology; then assembling the silicon mold on a copper base of a lower mold of the mold; then smelting the mixed raw materials repeatedly; then vacuumizing a cavity to a vacuum state; then injecting the molten raw materials into the cavity for pressure casting; and finally, taking out a formed amorphous alloy microneedle workpiece after a part isformed. Compared with a conventional metal microneedle, the amorphous alloy provided by the invention is high in injection moulding capacity, good in mechanical property and higher in corrosion resistance, has certain antibacterial activity, and has a wide prospect in the biochemical field.

Description

technical field [0001] The invention belongs to the field of micro-nano medical parts manufacturing, and relates to amorphous alloy micro-nano injection molding and laser microhole processing on the amorphous surface, in particular to a method for manufacturing amorphous alloy microneedles. Background technique [0002] Numerous studies have shown that the skin is very promising for the delivery of active pharmaceutical ingredients (APIs). Transdermal delivery mainly has the following advantages: efficient and precise controlled delivery, allowing sustained drug release, avoiding first liver metabolism and being drug-friendly to patients. Most APIs are fairly hydrophilic, charged or large in molecular size, making them far from ideal skin penetrants. Recent advances in transdermal drug delivery thus heighten the need for strategies to overcome the barrier function of the stratum corneum (SC) of the skin in order to facilitate rapid and efficient penetration of a wider range...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22D17/14B22D17/22B23K26/362
CPCB22D17/14B22D17/22B23K26/361
Inventor 王成勇袁志山杜策之张涛
Owner GUANGDONG UNIV OF TECH
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