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Contrast medium for improving nuclear magnetic resonance detection accuracy, preparation method and application

A technology of nuclear magnetic resonance and contrast agent, which is applied in preparations for in vivo tests, pharmaceutical formulas, emulsion delivery, etc., to achieve good water solubility, high relaxation performance, and the effect of saving medical expenses

Inactive Publication Date: 2018-07-06
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Studies have shown that double contrast reagents have many advantages over T1 or T2 imaging reagents alone, such as no difference in penetration depth between T1 and T2 images, no mismatch problems when moving samples between different imaging devices

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  • Contrast medium for improving nuclear magnetic resonance detection accuracy, preparation method and application
  • Contrast medium for improving nuclear magnetic resonance detection accuracy, preparation method and application
  • Contrast medium for improving nuclear magnetic resonance detection accuracy, preparation method and application

Examples

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preparation example Construction

[0042] Preparation method of contrast agent

[0043] In this example, the following steps are used to prepare a contrast agent for improving the accuracy of nuclear magnetic resonance detection. For the preparation process of Fe-Dy NPs, see figure 1 :

Embodiment 1

[0044] Embodiment 1: the preparation method of Fe-Dy NPs with a particle size of 18 nm

[0045] Add 0.1 g of iron and 0.1 g of dysprosium into 6 mM oleic acid and 6 mM oleylamine, and dissolve in 20 g of 1-octadecene. The mixture was heated to 300 ºC for 3 hours, and the obtained black precipitate was naturally cooled to room temperature, and Fe-Dy NPs could be obtained by precipitation with alcohol. Dissolve 2 mg of Fe-Dy NPs in cyclohexane, add 10 mL of dimethylformamide, add 100 mg of NOBF4, stir vigorously, and react at room temperature for 2.5 hours. 10 mL of toluene was added to obtain NPs without oleic acid coating, and the resulting precipitate was dissolved in 7.5 mL of cyclohexane, and PAA (concentration: 20 mg / mL) was added, and the reaction was stirred for more than 20 hours. Add 10 mL of acetone to precipitate PAA-coated NPs. NPs were dissolved in 5 mL of water and sonicated until completely dissolved. Water-soluble NPs were filtered at 2 µM and stored at 4 º...

Embodiment 2

[0046] Embodiment 2: the preparation method of Fe-Dy NPs with a particle size of 10 nm

[0047] Add 0.1 g iron and 0.125 g dysprosium to 6 mM oleic acid and 6 mM oleylamine, and dissolve in 20 g 1-octadecene. The mixture was heated to 300 ºC for 3 hours, and the obtained black precipitate was naturally cooled to room temperature, and Fe-Dy NPs could be obtained by precipitation with alcohol. Dissolve 2 mg of Fe-Dy NPs in cyclohexane, add 10 mL of dimethylformamide, add 100 mg of NOBF4, stir vigorously, and react at room temperature for 2.5 hours. 10 mL of toluene was added to obtain NPs without oleic acid coating, and the resulting precipitate was dissolved in 7.5 mL of cyclohexane, and PAA (concentration: 20 mg / mL) was added, and the reaction was stirred for more than 20 hours. Add 10 mL of acetone to precipitate PAA-coated NPs. NPs were dissolved in 5 mL of water and sonicated until completely dissolved. Water-soluble NPs were filtered at 2 µM and stored at 4 ºC.

[00...

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Abstract

The invention provides a contrast medium for improving the nuclear magnetic resonance detection accuracy. The contrast medium comprises nanoparticles containing iron and dysprosium. The invention alsoprovides a preparation method of the contrast medium and application thereof. The contrast medium provided by the invention meets the basic requirements of magnetic resonance imaging contrast media,has the advantages of high relaxation performance, low toxicity in animal bodies, good stability, selective distribution, good water solubility and easy discharge out of the body after examination, and is expected to be applied to timely, clear and reliable diagnosis.

Description

technical field [0001] The invention belongs to the field of nuclear magnetic resonance imaging contrast agent materials, and in particular relates to a contrast agent for improving the detection accuracy of nuclear magnetic resonance, a preparation method and an application. Background technique [0002] Liver B-ultrasound, spiral CT, and color Doppler can detect some signs of liver fibrosis, such as irregular or nodular liver outline, changes in the intensity of liver parenchyma, irregular or nodular, spleen Increased thickness, widened portal vein and splenic vein, etc. However, these imaging diagnoses are still unable to make a definite diagnosis of liver fibrosis and fibrosis degree, so they are clinically used as auxiliary diagnostic indicators of liver fibrosis. [0003] Magnetic resonance (MR) has many advantages in the diagnosis of liver fibrosis, including no radiation, no trauma, full-view evaluation, real-time imaging, etc. Physicians can also diagnose liver f...

Claims

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Application Information

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IPC IPC(8): A61K49/12A61K49/18
CPCA61K49/126A61K49/1854
Inventor 蒋兴宇刘野
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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