Semi-sandwich iridium complex having fluorescent property and containing N-N two-tooth chelated ligand, and preparation method and application of semi-sandwich iridium complex

Abstract

The invention relates to a semi-sandwich iridium complex having fluorescent properties and containing N-N two-tooth chelated ligand and belongs to the field of chemical pharmaceutical. The molecular structural formula of the iridium complex is as shown in the specification. As the iridium complex is creatively modified with rhodamine B, the whole complex has high anti-cancer activity and mitochondria targeting, has selectivity upon cancer cells, action process visibility and ideal purposes of real-time detection, and has a great significance on medicine targeting research. N-N is adopted as anion ligand for two-tooth chelation, the novel anionic iridium complex with relatively high anti-cancer activity and fluorescent properties can be synthesized, and the complex is good in effect and high in activity in cancer prevention and cell imaging.

Description

technical field [0001] The invention relates to a metal complex, in particular to a semi-sandwich iridium complex containing N^N bidentate chelating ligands with fluorescence characteristics, belonging to the field of chemical pharmacy. Background technique [0002] Cancer is one of the major diseases that seriously endanger human health. Overcoming cancer has always been a research topic attracting worldwide attention. Many metal complexes have anti-tumor activity and induce tumor cell apoptosis. Therefore, the research on the types, structures, properties, mechanisms of action and application status of anti-cancer drugs is the research content of anti-cancer drugs inducing tumor cell apoptosis. Therefore, it is a current research hotspot to search for new metal anticancer drugs with different mechanisms of action to improve or supplement the performance of existing platinum-based drugs. In addition, with the increasing research on cells, biomedical optical imaging such as...

AI Technical Summary

Problems solved by technology

However, these small organic molecules have some disadvantages: poor water solubility, easy to produce precipitation in water environment (such as culture medium) or precipitate out immediately after interacting with cells, affecting the dyeing effect; relatively high cytotoxicity, dyes interact with cells After that, it leads to cell death, which affects the observation of the normal state of the cell; the photostability is low, due to the action of the active agent group (singlet oxygen, etc.) in the air or in the medium, the fluorescence of the dye is continuously weakened after the excitation wavelength is irradiated , the phenomenon of photodrifting is serious, which is not conducive to stable imaging; the intersection of excitation and emission spectra is serious (the stoke shift is small), generally around tens of nanometers, which is not conducive to distinguishing endogenous fluorescence and reducing the self-quenching of the dye itself

However, since the half-sandwich iridium complex itself has no fluorescent properties, the understanding of the anti-cancer effect of the half-sandwich iridium complex is not deep enough. poor selectivity among cancer cells

Images