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A kind of preparation method of sugar-free type Ganmaozhike granules

A cold and cough-relieving, sugar-free technology is applied in the directions of medical preparations, pharmaceutical formulations, and drug combinations containing active ingredients, which can solve the problems of complex preparation methods, affecting the purity and effect of active ingredients of medicines, and achieve the loss of active ingredient content. Less, stable and feasible process parameters, high efficiency

Active Publication Date: 2020-10-02
HARBIN KANGLONG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation method of this application is relatively complicated, and it is easy to introduce new impurities, which will affect the purity and effect of the active ingredients of the drug.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A preparation method of sugar-free Ganmaozhike granules, comprising the steps of:

[0038] S1: Take bupleurum chinensis, forsythia japonicus and bitter almonds and add twice the amount of water, keep warm at 55°C for 45 minutes, pass steam distillation for 1 hour, collect the distillate, and continue steam distillation for 45 minutes to obtain the secondary distillate, combine the two distillations The liquid is the volatile oil part;

[0039] S2: Take scutellaria baicalensis, mountain silver flower, kudzu root and the medicinal residue obtained in step S1, add Bupleurum bupleurum, forsythia, bitter almond, scutellaria baicalensis, mountain silver flower and kudzu root to a mixed solution of acetic acid and sodium acetate that is 7 times the total weight, and heat at 45°C Under the temperature of above, ultrasonic extraction 3 times, each time 12min, filtrate and medicine dregs are filtered; Wherein, in the mixed solution of acetic acid and sodium acetate, the concentra...

Embodiment 2

[0045] A preparation method of sugar-free Ganmaozhike granules, comprising the steps of:

[0046] S1: Take bupleurum chinensis, forsythia japonicus and bitter almonds, add 2 times of water, keep warm at 50°C for 0.5h, put in steam for distillation for 1h, collect the distillate, continue to put in steam for 1h, get the second distillate, combine twice The distillate is the volatile oil part;

[0047] S2: Take scutellaria baicalensis, mountain silver flower, kudzu root and the medicinal residue obtained in step S1, add a mixed solution of acetic acid and sodium acetate that is 5 times the total weight of bupleurum, forsythia, bitter almond, scutellaria baicalensis, mountain silver flower and kudzu root, and heat at 40°C Under the temperature of above, ultrasonic extraction 2 times, each 15min, filter and obtain filtrate and dregs; Wherein, in the mixed solution of acetic acid and sodium acetate, the concentration of acetic acid is 20wt%, and the concentration of sodium acetate ...

Embodiment 3

[0053] A preparation method of sugar-free Ganmaozhike granules, comprising the steps of:

[0054] S1: Take bupleurum chinensis, forsythia japonicus and bitter almonds and add 3 times of water, keep warm at 60°C for 1 hour, steam for 1.5 hours, collect the distillate, and continue steam distillation for 30 minutes to obtain a secondary distillate, which is combined twice The distillate is the volatile oil part;

[0055] S2: Take scutellaria baicalensis, mountain silver flower, kudzu root and the medicinal residue obtained in step S1, add Bupleurum chinensis, forsythia, bitter almond, scutellaria baicalensis, mountain silver flower and kudzu root 5-8 times the mixed solution of acetic acid and sodium acetate, in At a temperature of 50°C, ultrasonic extraction was performed 3 times, each time for 10 minutes, and the filtrate and medicinal residues were obtained by filtration; wherein, in the mixed solution of acetic acid and sodium acetate, the concentration of acetic acid was 25...

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PUM

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Abstract

The invention relates to cold and cough-relieving granules and in particular discloses a preparation method of sugar-free cold and cough-relieving granules. The preparation method comprises the following steps: S1, taking radix bupleuri, fructus forsythiae and semen armeniacae amarae and adding water; extracting volatile parts; filtering to obtain filtrate and medicine dreg; S2, taking radix scutellariae and the medicine dreg obtained by S1; adding a mixed solution of acetic acid and sodium acetate; carrying out ultrasonic extraction and filtering to obtain filtrate and medicine dreg; S3, taking honeysuckle flowers, radix puerariae, herba artemisiae annuae, radix platycodonis and the medicine dreg obtained by S2; adding the filtrate of S1 and decocting with water to obtain a decocted solution; S4, taking the filtrate of S2 and the decocted solution obtained by S3 and combining; filtering through a membrane and decompressing and concentrating; S5, taking an extracted concentrated solution and spraying and drying to obtain spraying fine powder; S6, taking the spraying fine powder and adding cyclodextrin, sucralose and menthol crystal; spraying a volatile oil part and blending and granulating to obtain the sugar-free cold and cough-relieving granules. According to the preparation method of the sugar-free cold and cough-relieving granules, active components in medicines are effectively extracted and the curative effect of a medicine is improved.

Description

technical field [0001] The invention relates to a Ganmaozhike granule, in particular to a preparation method of a sugar-free Ganmaozhike granule. Background technique [0002] Ganmaozhike granules are composed of Bupleurum chinensis, mountain silver flower, kudzu root, artemisia annua, forsythia, skullcap, bellflower, bitter almond and menthol. The above nine flavors, except menthol, and the other eight flavors such as Bupleurum, are decocted twice with water for 4 hours each time, the decoction is filtered, the filtrates are combined, and concentrated to an appropriate amount. The traditional method is prepared by wet granulation. The traditional extraction method only uses water extraction, which cannot effectively extract the active ingredients in the drug, which affects the curative effect of the drug; moreover, due to the long drying time and large drying area of ​​the wet granulation method, the active ingredients in the drug are more damaged, and the product Unstable...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/736A61K9/16A61P11/00A61P11/14
CPCA61K9/1652A61K36/233A61K36/282A61K36/346A61K36/355A61K36/488A61K36/539A61K36/634A61K36/736A61K2236/331A61K2236/37A61K2300/00
Inventor 穆滨
Owner HARBIN KANGLONG PHARM CO LTD