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Preparation method of lacrimal duct plug with development function

A technology of lacrimal canaliculus and function, which is applied in the field of polymer material preparation, can solve the problems of small size of lacrimal duct plug, adjacent tissue lesions, and inability to accurately locate, etc., to achieve a simple and feasible preparation method, reduce rejection and inflammation, and facilitate postoperative surgery The effect of tracking

Inactive Publication Date: 2018-08-14
广州锐澄医疗技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the complex anatomical structure of the lacrimal duct and the narrow duct, blind implantation of emboli can easily lead to damage in the lacrimal duct, forming lacrimal duct granuloma, causing lacrimal duct adhesion, scarring of the lacrimal duct, and even causing lesions in adjacent tissues, leaving patients with a lifelong pain
Moreover, the size of the lacrimal plug is small, the self-fixation effect is not good, and it is easy to slip out of position, which is not conducive to postoperative tracking
[0003] The currently used canaliculus plug is usually fixed by using the end size larger than the physiological size of the lacrimal duct, the fixation effect is poor, the incidence of falling off is high, and the position of the canalicular plug cannot be accurately located before and after implantation and after falling off
The existing lacrimal canaliculus plugs are mainly obtained from materials such as polydioxanone, acrylic acid, and medical silicone rubber. These materials have relatively poor biocompatibility, poor self-fixation effect, and cannot be used in implants. Precise positioning before and after entering or after falling off

Method used

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  • Preparation method of lacrimal duct plug with development function
  • Preparation method of lacrimal duct plug with development function
  • Preparation method of lacrimal duct plug with development function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] An embodiment of the preparation method of the lacrimal canaliculus plug with developing function according to the present invention comprises the following steps:

[0032] (1), the preparation raw material of punctum plug is mixed uniformly, injects in the mould;

[0033] (2), react the mold at 50°C for 24 hours, solidify and form, and obtain a preliminary formed hydrogel;

[0034] (3), place the preliminarily formed hydrogel obtained in step (2) in a UV curing machine, irradiate with ultraviolet light for 10 minutes, and further solidify and form to obtain a formed hydrogel;

[0035] (4), take out the formed hydrogel obtained in step (3) from the mold, soak and wash with clear water for 3 days, take it out, and dry to obtain the lacrimal canaliculus plug with developing function;

[0036] Wherein, the raw materials for the preparation of the lacrimal canaliculus plug include the following components in parts by weight: 50 parts of hydroxyethyl methacrylate, 10 parts ...

Embodiment 2

[0041] An embodiment of the preparation method of the lacrimal canaliculus plug with developing function according to the present invention, the difference between the preparation method of the lacrimal canaliculus plug described in this embodiment and Example 1 is the thermal initiator in the raw materials for the preparation of the lacrimal canaliculus plug Different from the ratio of the photoinitiator, the punctal plug described in this embodiment contains the following preparation raw materials in parts by weight: 50 parts of hydroxyethyl methacrylate, 10 parts of polyethylene glycol diacrylate, ethylene glycol dimethacrylate 10 parts, 50 parts of water, 6 parts of photoinitiator, 6 parts of thermal initiator and 22 parts of barium sulfate;

[0042] The photoinitiator is a mixture of 2-hydroxyl-2-methylpropiophenone and 2,4,6-trimethylbenzoyl-diphenylphosphine oxide; the 2-hydroxyl-2-methylpropiophenone and 2,4,6-trimethylbenzoyl-diphenylphosphine oxide in a weight ratio ...

Embodiment 3

[0046] An embodiment of the preparation method of the lacrimal canaliculus plug with developing function according to the present invention, the difference between the preparation method of the lacrimal canaliculus plug described in this embodiment and Example 1 is the thermal initiator in the raw materials for the preparation of the lacrimal canaliculus plug Different from the ratio of the photoinitiator, the punctal plug described in this embodiment contains the following preparation raw materials in parts by weight: 50 parts of hydroxyethyl methacrylate, 10 parts of polyethylene glycol diacrylate, ethylene glycol dimethacrylate 10 parts, 50 parts of water, 8 parts of photoinitiator, 4 parts of thermal initiator and 22 parts of barium sulfate;

[0047] The photoinitiator is a mixture of 2-hydroxyl-2-methylpropiophenone and 2,4,6-trimethylbenzoyl-diphenylphosphine oxide; the 2-hydroxyl-2-methylpropiophenone and 2,4,6-trimethylbenzoyl-diphenylphosphine oxide in a weight ratio ...

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Abstract

The invention discloses a preparation method of a lacrimal duct plug with a development function. The method comprises the following steps of (1) uniformly mixing preparation raw materials of lacrimalduct plug; injecting the raw materials into a mold; (2) performing reaction in the mold for 18 to 26 h at 25 to 88 DEG C; performing curing shaping to obtain primarily formed water gel; (3) performing ultraviolet radiation for 5 to 30min on the primarily shaped water gel obtained in the step (2); performing further curing shaping to obtain the shaped water gel; (4) taking out the water gel shapedin the step (3) from the mold; performing soaking washing by clean water for 2 to 4 days; then, taking out the water gel; performing drying; obtaining the lacrimal duct plug with the development function. The lacrimal duct plug with the development function uses hydroxyethyl methacrylate as a substrate; in addition, a development agent is loaded in the lacrimal duct plug; after the implementationin the operation, the water absorption expansion can be realized; the self fixing effect is achieved; the exclusion and inflammation are reduced; the lacrimal passage condition of a patient is accurately judged; the postoperative tracking is convenient.

Description

technical field [0001] The invention relates to a preparation method of a polymer material, in particular to a preparation method of a lacrimal canaliculus plug with a developing function. Background technique [0002] The etiology of dry eye is complex, and the condition is affected by many factors such as age, sex hormone levels, autoimmune diseases, antihistamines, corneal refractive surgery, and environmental conditions. In recent years, the rise of lacrimal plugs has provided a new idea for the treatment of dry eye. However, due to the complex anatomical structure of the lacrimal duct and the narrow duct, blind implantation of emboli can easily lead to damage in the lacrimal duct, forming lacrimal duct granuloma, causing adhesion of the lacrimal duct, scarring of the lacrimal duct, and even lesions of adjacent tissues, which leaves patients with considerable Pain for life. Moreover, the size of the lacrimal plug is small, the self-fixation effect is not good, and it i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F283/06C08F220/20C08F2/44C08F2/48C08K3/30C08K3/22A61L24/06A61L24/00
CPCA61L24/001A61L24/06C08F283/065C08K3/22C08K3/30C08K2003/2244C08K2003/3045C08F220/20C08L51/08
Inventor 李锐聪杨习锋曾晨光郭少成
Owner 广州锐澄医疗技术有限公司