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Blood activated coagulation time determination biosensor and manufacturing method thereof

A technology of biosensor and coagulation time, which is applied in the field of medical detection, can solve the problem of inability to accurately detect blood clots, and achieve the effect of reducing inherent changes, ensuring accuracy and reliability, and accurate coagulation time

Pending Publication Date: 2018-08-14
GUANGZHOU WONDFO BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the study found that even low doses of heparin (up to 2.5 units / mL of blood) could not accurately detect the presence of blood clots

Method used

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  • Blood activated coagulation time determination biosensor and manufacturing method thereof
  • Blood activated coagulation time determination biosensor and manufacturing method thereof
  • Blood activated coagulation time determination biosensor and manufacturing method thereof

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Embodiment Construction

[0046] In order to facilitate the understanding of the present invention, the present invention will be described more fully below with reference to the associated drawings. Preferred embodiments of the invention are shown in the accompanying drawings. However, the present invention can be embodied in many different forms and is not limited to the embodiments described herein. On the contrary, these embodiments are provided to make the understanding of the disclosure of the present invention more thorough and comprehensive.

[0047] It should be noted that when an element is referred to as being “fixed” to another element, it can be directly on the other element or there can also be an intervening element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or intervening elements may also be present.

[0048] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as...

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Abstract

The invention discloses a blood activated coagulation time determination biosensor and a manufacturing method thereof. The biosensor comprises a bottom layer, a middle layer and an upper layer connected sequentially in a stacking way, wherein the middle layer is provided with a detection cell; the bottom layer and the upper layer face and correspond to a surface area of the detection cell so as tobe matched with cell walls of the detection cell to form a sample detection cavity in a surrounding way; dried coagulation accelerant coatings are arranged on an upper cavity wall of the sample detection cavity and a lower cavity wall between a working electrode and a reference electrode. Through the coagulation accelerant coatings on the top part, the bottom part and side walls of a coagulationreaction unit, an inherent change of the surface of a polymer is reduced maximally, a uniform contact surface is provided for accurate and consistent activated coagulation time determination, blood tobe tested and a dried coagulation accelerant can fully contact during activated coagulation time determination, a maximum contact surface is maintained, the blood and the coagulation accelerant can be fully mixed, and thus the accuracy and the reliability of an activated coagulation time determination result are further ensured.

Description

technical field [0001] The invention relates to the field of medical detection, in particular to a biosensor for measuring blood activation coagulation time and a manufacturing method thereof. Background technique [0002] ACT (activated clotting time, activated clotting time) measurement is usually used before, during or after bypass surgery, percutaneous transluminal coronary angioplasty, hemodialysis, extracorporeal life support (ECLS) and other operations , Such operations usually require a certain dose of heparin to prevent thrombosis. Especially in cardiopulmonary bypass patients, ACT is the key to determine the dosage of heparin. Heparin is excreted by the kidneys in a metabolically unsaturated manner, so blood coagulation must be checked every 15 to 20 minutes during surgery. When used without heparin, the normal ACT is about 120 seconds, while the ACT added with heparin is greater than 480 seconds. When the ACT is lower than 400 seconds to 480 seconds, another he...

Claims

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Application Information

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IPC IPC(8): G01N27/30G01N27/327G01N33/86
CPCG01N27/301G01N27/307G01N27/3275G01N33/86G01N33/5438G01N33/4905G01N2333/745
Inventor 张彤赵腾飞汤嘉慧方磊周楚青陈雨薇余绍炀王继华
Owner GUANGZHOU WONDFO BIOTECH
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