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Preparation method of spongy macroporous polyvinyl alcohol hydrogel

A technology of polyvinyl alcohol and polyvinyl alcohol solution is applied in the field of preparation of novel spongy macroporous polyvinyl alcohol hydrogels, which can solve the problems of limiting the application range and the lack of macroporous structure of hydrogels, and achieve high porosity. efficiency, good mechanical properties and biocompatibility, good application potential

Active Publication Date: 2018-08-17
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the hydrogel prepared by this method usually does not have a macroporous structure, which limits its application range.

Method used

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  • Preparation method of spongy macroporous polyvinyl alcohol hydrogel
  • Preparation method of spongy macroporous polyvinyl alcohol hydrogel
  • Preparation method of spongy macroporous polyvinyl alcohol hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Step 1: Weigh polyvinyl alcohol with a molecular weight of 89,000 Da and dissolve it in 20 ml of deionized water to obtain a polyvinyl alcohol solution with a mass-volume concentration of 10%, and place it in a 95°C water bath and stir to fully dissolve it;

[0038] Step 2: adding polyethylene glycol with a molecular weight of 1500 Da to the above solution to make it fully mixed to form a homogeneous solution, so that the concentration of polyethylene glycol by mass to volume is 8%;

[0039] Step 3: Place the mixed solution of polyvinyl alcohol and polyethylene glycol at room temperature for 1 h;

[0040] Step 4: Dissolve the nano-hydroxyapatite in the turbid mixed solution at a mass volume ratio concentration of 10% after the mixed solution becomes turbid;

[0041] Step 5: The above-mentioned mixed solution was placed at room temperature for 1 hour; then, a gel was prepared by a cycle freezing / melting method, wherein the freezing temperature was -20°C, the melting temp...

Embodiment 2

[0043] Step 1: Weigh polyvinyl alcohol with a molecular weight of 98,000 Da and dissolve it in 20ml of deionized water to obtain a polyvinyl alcohol solution with a mass fraction of 10%, and place it in a 95°C water bath and stir to fully dissolve it;

[0044] Step 2: adding polyethylene glycol with a molecular weight of 1500 Da to the above solution to make it fully mixed to form a homogeneous solution, so that the concentration of polyethylene glycol by mass to volume is 8%;

[0045] Step 3: Place the mixed solution of polyvinyl alcohol and polyethylene glycol at room temperature for 1 h;

[0046] Step 4: Dissolve the nano-hydroxyapatite in the turbid mixed solution at a mass volume ratio concentration of 6% after the mixed solution becomes turbid;

[0047] Step 5: The above-mentioned mixed solution was placed at room temperature for 1 hour; then, a gel was prepared by a cycle freezing / melting method, wherein the freezing temperature was -20°C, the melting temperature was ro...

Embodiment 3

[0049]Step 1: Weigh polyvinyl alcohol with a molecular weight of 98,000 Da and dissolve it in 20ml of deionized water to obtain a polyvinyl alcohol solution with a mass fraction of 8%, and place it in a 95°C water bath and stir to fully dissolve it;

[0050] Step 2: adding polyethylene glycol with a molecular weight of 3000 Da to the above solution to make it fully mixed to form a homogeneous solution, so that the polyethylene glycol mass volume ratio concentration is 4%;

[0051] Step 3: Place the mixed solution of polyvinyl alcohol and polyethylene glycol at room temperature for 1 hour;

[0052] Step 4: Dissolve the nano-hydroxyapatite in the turbid mixed solution at a mass volume ratio concentration of 10% after the mixed solution becomes turbid;

[0053] Step 5: Place the above-mentioned mixed solution at room temperature for 1 hour; then prepare a gel by cyclic freezing / melting method, wherein the freezing temperature is -20°C, the melting temperature is room temperature,...

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Abstract

The invention discloses a preparation method of novel spongy macroporous polyvinyl alcohol hydrogel. The preparation method comprises the following specific steps: dissolving polyethylene glycol in apolyvinyl alcohol solution, enabling the mixed solution to be subjected to phase separation by reducing the temperature, and then, adding nano hydroxyapatite to the mixed solution subjected to phase separation so as to stabilize the phase separation system; and forming the hydrogel by a cyclic freezing / melting method, and washing out polyethylene glycol and nano hydroxyapatite, thereby obtaining the polyvinyl alcohol hydrogel with a macroporous structure. Compared with the polyvinyl alcohol hydrogel which is not added with hydroxyapatite and is prepared only by the cyclic freezing / melting method, the hydrogel prepared by the preparation method disclosed by the invention has the advantages of appearance and elasticity similar to those of sponge, three-dimensional perforated porous structure, high porosity (pore size is 30-100mu m), and good mechanical properties and biocompatibility. The spongy macroporous polyvinyl alcohol hydrogel has great application potential in the field of biomedical materials.

Description

technical field [0001] The invention relates to a preparation method of a novel spongy macroporous polyvinyl alcohol hydrogel, which belongs to the field of biochemical industry. Background technique [0002] Hydrogels are hydrophilic polymers with a three-dimensional network structure produced by chemical or physical crosslinking. It can absorb a lot of water to swell and keep a certain shape. Typical hydrogels are often jelly-like, soft and elastic. Good water absorption, water retention and slow release characteristics make it show good application prospects in the fields of tissue engineering, wound dressing and drug slow and controlled release. [0003] Materials for preparing hydrogels can be divided into two categories: natural polymer materials and chemically synthesized polymer materials. The preparation methods are usually physical cross-linking and chemical cross-linking. Physical cross-linking refers to the interaction between ionic bonds, hydrogen bonds and hy...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08J9/26C08J9/28C08L29/04
CPCC08J3/075C08J9/26C08J9/28C08J2201/0444C08J2201/0464C08J2205/044C08J2329/04
Inventor 朱晨辉范代娣冯瑞蕊惠俊峰
Owner NORTHWEST UNIV
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