Insulin mesoporous carbon particles and its preparation method, oral preparation and application

A mesoporous carbon and insulin technology, applied in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve problems such as insulin instability and liver first-pass effect, and save preparation time. , The preparation method is simple and the effect of fast excretion in the body

Active Publication Date: 2020-05-29
GUANGDONG PHARMA UNIV
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Problems solved by technology

[0021] The technical problem to be solved by the present invention is to provide an oral preparation made of insulin mesoporous carbon particles, which solves the problems of insulin instability in the digestive tract environment and the first-pass effect of the liver, realizes oral administration, and Guaranteed high-efficiency treatment of oral peptides

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  • Insulin mesoporous carbon particles and its preparation method, oral preparation and application
  • Insulin mesoporous carbon particles and its preparation method, oral preparation and application
  • Insulin mesoporous carbon particles and its preparation method, oral preparation and application

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Embodiment Construction

[0050] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings.

[0051] The invention provides insulin mesoporous carbon particles, which include mesoporous carbon and insulin, the insulin is embedded in the mesoporous carbon, and the dosage ratio of the insulin to the mesoporous carbon is 3-6:10-15. Preferably, the dosage ratio of insulin to mesoporous carbon is 4-5:11-13. More preferably, the dosage ratio of insulin to mesoporous carbon is 4:12.

[0052] Mesoporous carbon is a new type of non-silicon-based mesoporous material, 2nm2 / g) and pore volume (up to 2.25cm 3 / g), to provide greater drug loading. Compared with pure mesoporous silicon materials, mesoporous carbon materials exhibit special properties, such as high specific surface area and high porosity; the pore size can be adjusted within a certain range; Adjustabl...

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Abstract

The invention discloses insulin mesoporous carbon particles comprising mesoporous carbon and insulin; insulin is embedded into mesoporous carbon; and the amount ratio of insulin to mesoporous carbon is 3-6:10-15. The invention also discloses a preparation method of the insulin mesoporous carbon particles, an oral preparation prepared from the insulin mesoporous carbon particles, and applications of the insulin mesoporous carbon particles in treatment of diabetes. The preparation method is simple; biocompatibility is high; toxic reaction of cells or internal organs is not caused; in vivo metabolism is relatively rapid. The oral preparation is capable of solving problems that insulin is not stable at alimentary canal environment and liver first pass effect is caused; oral administration is realized; and high efficiency treatment effect of polypeptide oral administration is ensured.

Description

technical field [0001] The invention relates to the technical field of insulin medication, in particular to an insulin mesoporous carbon particle and its preparation method, oral preparation and application. Background technique [0002] At present, for diabetic patients, insulin is still the primary drug for maintaining blood sugar levels by promoting blood sugar intake. Today, insulin is still the first-line drug for the treatment of type 1 diabetes, and it is also effective for patients with type 2 diabetes. Insulin is mainly administered by subcutaneous injection and cannot be taken orally because of its instability in the digestive tract environment, including the influence of gastric acid and protease, low intestinal wall permeability, and the first-pass effect of the liver. However, long-term subcutaneous injection of insulin can lead to infection at the injection site and increase the psychological stress of patients, resulting in decreased patient compliance and in...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/69A61K38/28A61P3/10
CPCA61K38/28
Inventor 臧林泉王秀芳林浩荣
Owner GUANGDONG PHARMA UNIV
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