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Compound injection of paracetamol pharmaceutical composition as well as preparation method and application thereof

A paracetamol and injection technology, applied in the directions of drug combination, antipyretic, drug delivery, etc., can solve the problems of restricting the application of antipyretic and analgesic treatment, reducing the curative effect, liver damage, etc., and achieve high-efficiency antipyretic and analgesic effect, obvious Curative effect, the effect of slowing down the damage of the liver

Inactive Publication Date: 2018-08-24
JILIN BAINIAN HANKE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although paracetamol is a good antipyretic and analgesic medicine, taking it for a long time or taking too much will cause damage to the human liver. Therefore, for safety reasons, the amount and frequency of taking it must be strictly controlled, but the curative effect has been greatly reduced. , seriously restricting its application in antipyretic and analgesic treatment

Method used

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  • Compound injection of paracetamol pharmaceutical composition as well as preparation method and application thereof
  • Compound injection of paracetamol pharmaceutical composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A compound paracetamol injection pharmaceutical composition, comprising the following raw materials in parts by weight:

[0029] Paracetamol 8g, angelica extract 50mL, smilax extract 30mL, allicin solution 700mL, licorice extract 70mL, dandelion extract 30mL, isatidis extract 90mL, solvent 50mL, dilute to 1000mL with water for injection.

[0030] Its preparation method comprises the following steps:

[0031] S1: heat the solvent to 45°C, then add paracetamol to it, stir to dissolve it fully, and obtain solution 1;

[0032] S2: Mix the extract of Angelica sinensis, Smilax smilax extract, allicin, licorice extract, Dandelion extract and Radix isatidis extract to obtain solution 2;

[0033] S3: After the temperature of solution 1 is cooled to room temperature, fully mix solution 1 and solution 2, and then dilute to 1000 mL with water for injection to obtain a mixed injection;

[0034] S4: adjusting the pH of the mixed injection obtained in step S3 to 6.5;

[0035] S5: f...

Embodiment 2

[0038] A compound paracetamol injection pharmaceutical composition, comprising the following raw materials in parts by weight:

[0039] Paracetamol 10g, angelica extract 65mL, smilax extract 50mL, allicin 85mL, licorice extract 85mL, dandelion extract 45mL, isatidis extract 105mL, solvent 80mL, dilute to 1000mL with water for injection.

[0040] Its preparation method comprises the following steps:

[0041] S1: heat the solvent to 48°C, then add paracetamol to it, stir to dissolve it fully, and obtain solution 1;

[0042] S2: Mix the extract of Angelica sinensis, Smilax smilax extract, allicin, licorice extract, Dandelion extract and Radix isatidis extract to obtain solution 2;

[0043] S3: After the temperature of solution 1 is cooled to room temperature, fully mix solution 1 and solution 2, and then dilute to 1000 mL with water for injection to obtain a mixed injection;

[0044] S4: adjusting the pH of the mixed injection obtained in step S3 to 6.8;

[0045] S5: filter th...

Embodiment 3

[0048] A compound paracetamol injection pharmaceutical composition, comprising the following raw materials in parts by weight:

[0049] Paracetamol 12g, angelica extract 80mL, soil tuckahoe extract 70mL, allicin solution 100mL, licorice extract 100mL, dandelion extract 60mL, isatidis extract 120mL, solvent 100mL, dilute to 1000mL with water for injection.

[0050] Its preparation method comprises the following steps:

[0051] S1: heat the solvent to 50°C, then add paracetamol to it, stir to dissolve it fully, and obtain solution 1;

[0052] S2: Mix the extract of Angelica sinensis, Smilax smilax extract, allicin, licorice extract, Dandelion extract and Radix isatidis extract to obtain solution 2;

[0053] S3: After the temperature of solution 1 is cooled to room temperature, fully mix solution 1 and solution 2, and then dilute to 1000 mL with water for injection to obtain a mixed injection;

[0054] S4: Adjust the pH of the mixed injection solution obtained in step S3 to 7.0...

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Abstract

The invention relates to a compound injection of paracetamol pharmaceutical composition as well as a preparation method and application thereof. According to the compound injection of paracetamol pharmaceutical composition as well as the preparation method and application thereof, 8-12 g of paracetamol, 50-80 mL of radix angelicae sinensis extracting solution, 30-70 mL of rhizoma smilacis glabraeextracting solution, 70-100 mL of allicin liquid, 70-100 mL of liquorice root extracting solution, 30-60 mL of dandelion extracting solution, 90-120 mL of isatis root extracting solution and 50-100 mLof solvent are prepared into the compound injection in paracetamol pharmaceutical composition through reasonable proportion and scientific compatibility of medicines, and the compound injection of paracetamol pharmaceutical composition is applied to the aspects of treating fever, headache, arthralgia and neuralgia, not only has efficient antipyretic and analgesic effects, but also is safe and reliable, and has a small side effect on a human body.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical compositions, in particular to a compound paracetamol injection pharmaceutical composition and its preparation method and application. Background technique [0002] Paracetamol, namely acetaminophen, is an over-the-counter drug with antipyretic and analgesic effects, and is widely used in the treatment of symptoms such as fever, headache, joint pain and neuralgia. Although paracetamol is a good antipyretic and analgesic medicine, taking it for a long time or taking too much will cause damage to the human liver. Therefore, for safety reasons, the amount and frequency of taking it must be strictly controlled, but the curative effect has been greatly reduced. , seriously restricting its application in antipyretic and analgesic treatment. Therefore, it is necessary to develop a new efficient and safe paracetamol composition to promote human health. Contents of the invention [0003] In orde...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/90A61K36/896A61K9/08A61P29/00A61P25/00A61P19/02A61K31/167A61K31/255
CPCA61K9/0019A61K9/08A61K31/167A61K31/255A61K36/195A61K36/232A61K36/288A61K36/315A61K36/484A61K36/896A61K36/90A61K47/10A61K2236/331A61K2236/333A61K2236/39A61P19/02A61P25/00A61P29/00A61K2300/00
Inventor 费青张丹张恒张戈
Owner JILIN BAINIAN HANKE PHARM CO LTD