Acetanilide and high-efficiency synthesis method thereof

A synthetic method and technology of acetanilide, which is applied in the preparation of carboxylic acid amide, chemical instruments and methods, and the preparation of organic compounds, etc., can solve the problems of not being able to start and stop at any time, and continuous production cannot be realized, so as to improve the utilization rate, Raw material saving and high purity effect

Active Publication Date: 2018-08-24
新乡市锦源化工有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method cannot achieve continuous production, nor can it be turned on and off during the reaction process.

Method used

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Examples

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preparation example Construction

[0015] The invention provides a high-efficiency synthesis method of acetanilide, which comprises: separately atomizing the mixed solution of hydrochloric acid and water and aniline and then mixing them. Pass the mixed material through the preheated inert gas into the stirring sodium acetate solution, and at the same time pass the acetic anhydride into the sodium acetate solution.

[0016] In a specific operation, the aniline is atomized to obtain the first raw material. In a preferred embodiment of the present invention, before the aniline is atomized, the aniline is heated to 120-140° C., filtered through an activated carbon filter, and the obtained filtrate is atomized.

[0017] Because aniline contains certain impurities, it will change color after being stored for a certain period of time, resulting in the phenomenon of yellowing of the synthesized acetanilide. The activated carbon filter is used to filter the aniline, which has a certain effect on removing the impurities...

Embodiment 1

[0040] A kind of efficient synthetic method of acetanilide, comprising:

[0041] Heat 10.5mL of aniline to 120-140°C and filter through an activated carbon filter, and atomize the filtrate with an atomizer to obtain the first raw material. Mix 10 mL of concentrated hydrochloric acid and water and atomize with another atomizer to obtain the second raw material. The first raw material and the second raw material are respectively fed into the mixing chamber for 2 minutes and mixed simultaneously to obtain a mixed material.

[0042]Prepare 100 mL of sodium acetate solution with a molar concentration of 3.6 mol / L, and use stirring blades to stir at a speed of 350 r / min between 1 / 2 of the liquid surface of the sodium acetate solution and 1 / 3 of the distance from the liquid surface of the sodium acetate solution . Use helium heated to 200°C to blow the mixture into the middle of the sodium acetate solution, and at the same time, slowly and uniformly pass 14.5mL of acetic anhydride ...

Embodiment 2

[0045] A kind of efficient synthetic method of acetanilide, comprising:

[0046] Heat 11 mL of aniline to 120-140° C. and filter through an activated carbon filter, and atomize the filtrate with an atomizer to obtain the first raw material. Mix 10 mL of concentrated hydrochloric acid and 245 mL of water and atomize with another atomizer to obtain the second raw material. The first raw material and the second raw material are respectively fed into the mixing chamber for 2 minutes and mixed simultaneously to obtain a mixed material.

[0047] Prepare 100 mL of sodium acetate solution with a molar concentration of 3.8 mol / L, and use stirring blades to stir at a speed of 380 r / min between 1 / 2 of the liquid surface of the sodium acetate solution and 1 / 3 of the distance from the liquid surface of the sodium acetate solution . Use helium heated to 180°C to blow the mixture into the middle of the sodium acetate solution, and at the same time, slowly and uniformly pass 15mL of acetic ...

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Abstract

The invention discloses acetanilide and a high-efficiency synthesis method thereof, and belongs to the field of chemical industry. The high-efficiency synthesis method comprises the following steps: atomizing aniline to obtain a first raw material, mixing concentrated hydrochloric acid and water, then atomizing to obtain a second raw material, sending the first raw material and the second raw material into a mixing chamber, and mixing to obtain a mixed material; stirring a sodium acetate solution, and introducing acetic anhydride into the sodium acetate solution while an inert gas obtained bypreheating the mixed material to 180-200 DEG C is brown into the sodium acetate solution. By the high-efficiency synthesis method, the reaction efficiency is high, the continuity is good, the reactioncan start and stop at any time, and the flexibility is good. The acetanilide is prepared according to the high-efficiency synthesis method, and is high in purity, low in cost and convenient to prepare.

Description

technical field [0001] The invention relates to the field of chemical industry, and in particular to a high-efficiency synthesis method of acetanilide and acetanilide. Background technique [0002] Acetanilide is the raw material of sulfa drugs, which can be used as analgesic, antipyretic and antiseptic. Acetanilide is also used to manufacture dye intermediates such as p-nitroacetanilide, p-nitroaniline, p-phenylenediamine and para-ester. It was widely used in the manufacture of acetaminophensulfonyl chloride during World War II. Acetanilide is also used in the manufacture of thioacetamide. In industry, it can be used as a rubber vulcanization accelerator, a stabilizer for cellulosic coatings, a stabilizer for hydrogen peroxide, and for the synthesis of camphor, etc. Therefore, the synthesis technique of acetanilide is of great significance in practical application. [0003] In the prior art, the reaction of aniline and acetic anhydride is a common method for synthesizin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C231/02C07C233/07
CPCC07C231/02C07C233/07
Inventor 蔡红新闫玲玲王真真陈东梅王书擘
Owner 新乡市锦源化工有限公司
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