A NMR Localized Spectroscopy Method for Non-Invasive Observation of Emulsion Formation Process

Abstract

The invention provides a nuclear magnetic resonance (MRS) localization spectrum method for non-invasively observing an emulsion formation process. The nuclear magnetic resonance localization spectrummethod comprises the following steps: preparing emulsion and sufficiently shaking and mixing by utilizing a vortex oscillator; introducing PRESS and GEMS pulse sequences of a nuclear magnetic resonance localization spectrum on a nuclear magnetic resonance spectrometer; setting pulse sequence parameters and sampling parameters and carrying out data acquisition and data post-processing to obtain high-resolution MRS spectrums of different space positions and a GEMS image of a whole body of a sample; carrying out integration on oil signal strength in the MRS spectrum and obtaining stable formationtime of the emulsion and judging the thickness of an emulsifying layer through analyzing an evolution law of the signal strength at the different space positions. The method provided by the inventionhas the advantages that small voxel sampling is adopted; with regard to a non-uniform emulsion dynamic system, the signal-to-noise ratio and resolution ratio of the obtained MRS spectrum are still very high and the method is suitable for carrying out quantitative analysis.

Description

technical field [0001] The invention relates to a magnetic resonance localized spectrum detection method, in particular to a magnetic resonance localized spectrum method for non-invasively observing the migration change of substances in the process of emulsion formation. Background technique [0002] Magnetic Resonance Imaging (MRI) technology has made outstanding contributions to medical diagnosis. After NMR technology was used in medical diagnosis in the 1970s, MRI technology has achieved rapid development in just a few decades. However, the image information obtained from MRI is mainly limited to the tissue structure, in fact, it is mainly the image of the spatial distribution of water and fat. Magnetic resonance spectroscopy (Magnetic Resonance Spectroscopy, MRS) is a method that combines magnetic resonance imaging and conventional spectroscopy. It is the only non-invasive technique to obtain quantitative information and diagnostic information of biochemical parameters i...

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Problems solved by technology

In recent years, NMR technology is mainly used to obtain the droplet size (Denkova et al., 2004) and particle size distribution (Slavka et al., 2003; Tuuk et al., 2016) of the emulsion by measuring the self-diffusion coefficient of the water-oil component in the emulsion. ), but there are still few research results on the mechanism of emulsion formation and the migration and change of substances during the phase transition process.

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