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Extracting method and application of traditional Chinese medicine extracts in whitening cosmetics

An extraction method and technology of traditional Chinese medicine, which are used in cosmetics, cosmetic preparations, drug combinations and other directions to achieve the effects of improving stability and increasing inhibition rate

Active Publication Date: 2018-09-11
陈思
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no literature report that the extract of Simiao Yong'an Decoction can be developed into an additive for cosmetics with whitening effect

Method used

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  • Extracting method and application of traditional Chinese medicine extracts in whitening cosmetics
  • Extracting method and application of traditional Chinese medicine extracts in whitening cosmetics
  • Extracting method and application of traditional Chinese medicine extracts in whitening cosmetics

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Experimental program
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Effect test

preparation example Construction

[0029] Preparation of tyrosinase solution: Accurately weigh tyrosinase and prepare about 200U·mg with phosphate solution of pH=6.8 -1 The enzyme solution was stored frozen at -20°C and thawed at 4°C before use.

[0030] Preparation of dopa solution: Accurately weigh L-dopamine, first use a small amount of 0.1mol L -1 Dissolve hydrochloric acid solution completely, and then add PBS solution to prepare 1.5mg·mL -1 Dopa solution, refrigerated at 4°C protected from light.

[0031] Treatment of test solution for tyrosinase inhibition experiment: Dilute the extract to a concentration of 100mg·mL with a phosphate solution of pH=6.8 -1 of the test solution.

Embodiment 1

[0033] According to the weight ratio, Flos Lonicerae: Ginseng: Angelica: Radix Glycyrrhizae=3:3:2:1 is mixed and pulverized, and then 400 mesh sieves are used to obtain Chinese medicine powder for use;

[0034] Screening of extraction solvents:

[0035] Take 10.0g of pulverized traditional Chinese medicine powder and add it to 100g of solvent, extract at 50-60°C for 10-12h and then filter to obtain the filtrate; concentrate the filtrate under reduced pressure at 40-60°C until no distillate is evaporated to obtain a paste , then added to 20ml of water and ultrasonicated for 1-2h, placed in a lyophilizer, pre-frozen at -5°C for 6-8h, and then lyophilized at -30°C to obtain whitening agents derived from traditional Chinese medicine obtained in different solvents, using biochemical enzymatic methods Test the inhibitory rate of tyrosinase, the traditional Chinese medicine source whitening agent that different solvents obtain is shown in Table 2:

[0036] Table 2 The influence of s...

Embodiment 2

[0040]The classic prescription Simiao Yong’an Decoction is three liang each of honeysuckle and ginseng, two liang of angelica, and one liang of licorice, that is, calculated according to the weight ratio, honeysuckle: yuan ginseng: angelica: licorice = 3:3:2:1; but This prescription is not necessarily optimal proportioning to tyrosinase inhibitory effect, so the present invention has carried out further optimization to its proportioning, method is as follows:

[0041] According to different weight ratios, honeysuckle, root ginseng, angelica, and licorice are mixed and pulverized, and then 400 mesh sieves are used to obtain Chinese medicine powder for use; 10.0 g of pulverized Chinese medicine powder is added to 100 g of solvent (weight ratio acetone / water / acetic acid Ethyl ester = 1:1:1), extract at 50-60°C for 10-12h and then filter to obtain the filtrate; concentrate the filtrate at 40-60°C under reduced pressure until no distillate is evaporated to obtain a paste, then add ...

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Abstract

The invention belongs to the technical field of cosmetics, and particularly relates to an extracting method and application of traditional Chinese medicine extracts in whitening cosmetics. A traditional Chinese medicine classic famous formula, namely a Simiaoyong'an decoction formula, is regarded as the research object for the first time, mixed liquid of acetone, ethyl acetate and water serves asan extraction agent for extracting a high-tyrosinase-inhibition-rate extract traditional Chinese medicine source whitening agent from a mixture of flos lonicerae, radix scrophulariae, radix angelicaesinensis and licorice root, and the traditional Chinese medicine source whitening agent can be used for preparing whitening lotions, whitening creams, whitening toners and other forms of cosmetics. The traditional Chinese medicine source whitening agent is provided for overcoming the defect that a chemical whitening agent has cytotoxicity and is harmful to human bodies.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to an extraction method and application of a traditional Chinese medicine extract for whitening cosmetics. Background technique [0002] With the rapid development of my country's economy, people pay more and more attention to "beauty". The cosmetics industry is booming at this time, and "whitening" is an eternal topic in the cosmetics industry. There are many kinds of whitening raw materials and products on the market, which give cosmetic engineers, manufacturers and users a great choice, but at the same time, it causes the non-standardization of the cosmetics market and increases the difficulty of supervision by relevant departments. [0003] Tyrosinase is the only known enzyme in melanin metabolism that plays a key role in melanin biosynthesis. It controls the process of melanin formation, and its activity level plays a major role in the amount and deposition of pig...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61Q19/02A61Q19/00A61K36/808A61P17/16
CPCA61K36/232A61K36/355A61K36/484A61K36/808A61K2236/333A61K2800/10A61K2800/782A61K2800/805A61Q19/00A61Q19/02A61K8/9789A61P17/16A61K2300/00
Inventor 张言聚李峰朱玉霞高威锋高建成
Owner 陈思
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