A nanoparticle with excellent blood stability and preparation method thereof

A nanoparticle, stable performance technology, applied in the field of nanoparticle and its preparation, can solve the problems of limiting the use of nanomedicine and the inability to significantly improve the bioavailability of nanomedicine
CN108542893BActive Publication Date: 2020-07-07SUN YAT SEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SUN YAT SEN UNIV
Publication Date
2020-07-07

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Abstract

The invention belongs to the technical field of nano-medicines, and provides a nano-particle with an excellent blood stabilizing performance, and a preparation method thereof. Poly(glycolide-co-lactide) (PLGA), a medicine / probe molecule, distearoyl phosphoethanolamine-polyethylene glycol-maleimide (DSPE-PEG) and pluronic F127 (PF127) which are used as raw materials undergo a rapid nanoprecipitation technique to prepare the nano-particle having the advantages of controlled particle size, good monodispersity, and excellent stability and performances in various solutions. A large number of hydroxyl groups and negative charges on the surface of the particle have a protection effect, so the nano-particle do not bind to proteins in serum, thereby the protein is avoided from being absorbed and metabolized by the reticuloendothelial system; and the hydrophobic medicine and the hydrophobic or amphipathic probe are encapsulated, so the particle can significantly prolong the blood circulation half-life of the medicine and the probe, and provides a good medicine delivery platform for disease detection and treatment.
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Description

technical field

[0001] The invention relates to the technical field of nanomaterials, in particular to a nanoparticle with excellent blood stability and a preparation method thereof. Background technique

[0002] Clinically, intravenous injection or infusion is often used to deliver drugs into the body for disease treatment. However, after the drug enters the blood circulation, a large part will be captured by the protein in the blood and transported to the liver and kidney for metabolism through the reticuloendothelial system, and finally excreted from the body, resulting in extremely low bioavailability of the drug, and has immunosuppression, tissue damage and neurotoxic side effects. With the continuous advancement of nanotechnology and medicine, a large number of nanomedicines have been designed to achieve targeted drug delivery (such as folic acid and other small molecules, vascular endothelial growth factor receptors, etc.) Drug side effects, improve drug bioavailabi...

Claims

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