Innovative type ingredient saccharose and preparation method thereof

A technology of sucrose and excipients, which is applied in pharmaceutical formulations, sugar-containing food ingredients, medical preparations with non-active ingredients, etc., and can solve problems such as high energy consumption, environmental pollution, and limited product purity

Inactive Publication Date: 2018-09-21
天津信诚康达药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The problem to be solved by the present invention is to overcome the defects of the existing production technology, that is, to overcome the need to invest in large-scale production equipment, high energy consumption and certain pollution to the environment in the existing preparation process, and to overcome the need to dissolve sucrose and introduce other substances in the preparation process Such as anti-crystallization agent and other defects such as limited product purity, an innovative auxiliary material sucrose is provided. This innovative auxiliary material sucrose has compressibility, good fluidity, a wide range of purity and can be set according to actual requirements, and the water content is very high. Small, easy to store and transport, no pollution to the environment during the production process, all ingredients are soluble in water, convenient for the production and use of food, health care products and pharmaceuticals, retaining the natural flavor of sucrose and improving the chewing feeling

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Prescription: sucrose 1000g

[0032] 1. Grind the prescribed amount of sucrose, pass it through an 80-mesh sieve, and add it to the dry granulator;

[0033] 2. Adjust the working pressure of the pressure roller of the dry granulator to 80bar, the gap between the pressure rollers to 0.6mm, and the speed of the pressure roller to 8rpm. Run the machine to press out a large piece with a thickness of about 0.8mm;

[0034] 3. Install a sizing screen with an aperture of 0.7 mm, and carry out sizing of the above-mentioned large flakes with a sizing cutter rotating speed of 200 rpm;

[0035] 4. Sieve out the sucrose particles with a particle size of 425 microns to 850 microns required by the customer to obtain the compressible sucrose fine particles of the present invention;

Embodiment 2

[0037] Prescription: 900g of sucrose, 100g of lactose.

[0038] 1. Crush the prescribed amount of sucrose, pass through an 80-mesh sieve with lactose, mix evenly, and add to the dry granulator;

[0039] 2. Adjust the working pressure of the pressure roller of the dry granulator to 90bar, the gap between the pressure rollers to 0.9mm, and the speed of the pressure roller to 12rpm, run the machine, and press out a large piece with a thickness of about 1.1mm;

[0040] 3. Install a sizing screen with an aperture of 0.7 mm, and carry out sizing of the above-mentioned large slices with a sizing cutter rotating speed of 150 rpm;

[0041] 4. Sieve out the sucrose granules with a particle size of 425 microns to 850 microns required by the customer to obtain the compressible sucrose fine particles of the present invention.

Embodiment 3

[0043] Prescription: 800g sucrose, 200g glucose.

[0044] 1. Crush the prescribed amount of sucrose, pass through an 80-mesh sieve with glucose, mix evenly, and add it to the dry granulator;

[0045] 2. Adjust the working pressure of the pressure roller of the dry granulator to 100bar, the gap between the pressure rollers to 1.2mm, and the speed of the pressure roller to 15rpm. Run the machine to press out a large piece with a thickness of about 1.3mm;

[0046] 3. Install a sizing screen with an aperture of 1.0 mm, and carry out sizing of the above-mentioned large slices with a sizing cutter rotating speed of 100 rpm;

[0047] 4. Sieve out the sucrose granules with a particle size of 425 microns to 850 microns required by the customer to obtain the compressible sucrose fine particles of the present invention.

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Abstract

The invention relates to an innovative type ingredient saccharose and a preparation method thereof, and belongs to the technical field of medicine and food. The innovative type ingredient saccharose is fine particles, the grain diameters of the innovative type ingredient saccharose range from 425 microns to 850 microns, the water content is smaller than 0.5%, the bulk density is 0.55-0.78 g/ml, and the angle of repose is smaller than 30 degrees. The innovative type ingredient saccharose has the advantages that compressibility, good fluidity and the wide purity range are achieved, the innovative type ingredient saccharose can be set according to actual requirements, has the small water content, and is easy to store and transport, the environment is not polluted in the production process, all ingredients can be completely dissolved in water, and production and use of food, healthcare products and medicine are promoted.

Description

technical field [0001] The invention relates to an innovative medical or food auxiliary material, in particular to an innovative auxiliary material sucrose and a preparation method thereof, belonging to the technical fields of medicine and food. Background technique [0002] As an important sweetener and energy source, sucrose is widely used in the production fields of food, health care products, and pharmaceuticals. However, the industrial production of sucrose generally uses the crystallization method. The sucrose crystal particles are relatively large, and the compressibility is very poor, which is not conducive to pressing into tablets. Therefore, it is difficult to directly apply to the production of pharmaceutical tablets, food tablets, health care tablets, etc.; Even if the sucrose is crushed, it is not easy to apply to direct tablet production because of its extremely poor fluidity, easy to absorb moisture and agglomerate, which is not easy to store. Physically modi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/26
CPCA23V2002/00A61K47/26A23L29/30A23V2250/60
Inventor 王志会马乔于雷解辉刘海霞吴华夏沈艳斌
Owner 天津信诚康达药业有限公司
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