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Method for catalytic synthesis of glycine in homogeneous system

A glycine and system technology, applied in chemical instruments and methods, preparation of organic compounds, ammonium chloride, etc., can solve the problems of low catalytic efficiency of hexamethamine, side reactions, and easy loss of catalysts, etc., and achieve increased follow-up treatment Difficulty, increasing the amount of precipitation, and avoiding the effect of ammonium chloride precipitation

Active Publication Date: 2018-09-21
SICHUAN FOURSTAR BIOTECH RANDD CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The purpose of the present invention is to provide a method for catalytically synthesizing glycine in a homogeneous system, adding substituted pyridine as a catalyst to synthesize glycine in the reaction system, which can effectively solve the problem of low catalytic efficiency of methamphetamine, easy loss of catalyst, serious side reactions, etc. It has the advantages of high conversion rate, easy purification of products, easy loss of catalyst and recyclable utilization, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033]This example proposes a method for catalytically synthesizing glycine in a homogeneous system. Specific steps are as follows:

[0034] A: Using chloroacetic acid and ammonia as raw materials, the ammonolysis reaction is carried out in the presence of a substituted pyridine catalyst (3,5-lutidine) and a solvent (methanol, ethanol and isopropanol).

[0035] B: Filter the reaction solution obtained from the ammonolysis reaction in step A, wash the filter cake to obtain the product glycine, and filter the mother liquor to carry out the operation of step C.

[0036] C: Cool and filter the filtered mother liquor obtained in step B to obtain a mixed crystal solid containing ammonium chloride and glycine, and reuse the filtered filtrate to step A.

[0037] D: The mixed crystal solid obtained in step C is washed, filtered and dried to obtain ammonium chloride product.

Embodiment 2

[0039] This example proposes a method for catalytically synthesizing glycine in a homogeneous system. Specific steps are as follows:

[0040] A: Using chloroacetic acid and ammonia as raw materials, the ammonolysis reaction is carried out in the presence of a substituted pyridine catalyst (2,4-lutidine) and a solvent (methanol). During production, control chloroacetic acid, ammonia, The molar ratio of 2,4-lutidine is 1:2.5:0.05, and the weight of methanol is twice that of chloroacetic acid.

[0041] B: Filter the reaction solution obtained from the ammonolysis reaction in step A, wash the filter cake to obtain the product glycine, and filter the mother liquor to carry out the operation of step C.

[0042] C: Cool and filter the filtered mother liquor obtained in step B to obtain a mixed crystal solid containing ammonium chloride and glycine, and reuse the filtered filtrate to step A.

[0043] D: The mixed crystal solid obtained in step C is washed, filtered and dried to obta...

Embodiment 3

[0045] This example proposes a method for catalytically synthesizing glycine in a homogeneous system. Specific steps are as follows:

[0046] A: Using chloroacetic acid and ammonia as raw materials, carry out ammonolysis reaction in the presence of substituted pyridine catalysts (4-picoline) and solvents (ethanol and ethylene glycol). During production, control chloroacetic acid and ammonia , The molar ratio of 4-picoline is 1:2.0:0.01, and the weight of ethanol and ethylene glycol is 8 times the weight of chloroacetic acid.

[0047] B: Filter the reaction solution obtained from the ammonolysis reaction in step A, wash the filter cake to obtain the product glycine, and filter the mother liquor to carry out the operation of step C.

[0048] C: Cool and filter the filtered mother liquor obtained in step B to obtain a mixed crystal solid containing ammonium chloride and glycine, and reuse the filtered filtrate to step A.

[0049] D: The mixed crystal solid obtained in step C is...

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Abstract

The invention discloses a method for catalytic synthesis of glycine in a homogeneous system. Chloroacetic acid and ammonia gas are used as raw materials, an ammonolysis reaction is carried out in thepresence of a substituted pyridine catalyst and a solvent, and glycine and ammonium chloride are obtained from the reaction liquid obtained through the ammonolysis reaction after filtrating, washing and other operations. In the method provided by the invention, the reaction system adopts a homogeneous system of alcohol and uses substituted pyridine as a catalyst, so that the problems of low catalytic efficiency of urotropine, easy loss of catalyst, serious side reactions and the like can be effectively solved; and the method has the advantages of high conversion rate, easy purification of products, difficult loss of the catalyst and recycle utilization, reduces the production cost, reduces pollution, and has a high practical value.

Description

technical field [0001] The invention is a method for catalytically synthesizing glycine in a homogeneous system, in particular to a new method for synthesizing glycine in a homogeneous system, and belongs to the technical field of chemical synthesis. Background technique [0002] Glycine, also known as aminoacetic acid, has the molecular formula C 2 h 5 NO 2 , structural formula NH 2 CH 2 COOH, molecular weight 75.07. Glycine is a white monoclinic or hexagonal crystal or white crystalline powder. It is the amino acid with the smallest molecular weight and the simplest structure among amino acids. As an important fine chemical intermediate, glycine is widely used in the fields of pesticide, medicine, food, feed, electroplating, organic synthesis and so on. In terms of pesticides, glycine can be used to produce herbicide glyphosate and plant growth regulator glyphosate; in medicine, glycine can be used in various amino acid infusion formulas, aureomycin buffer, L-dopa an...

Claims

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Application Information

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IPC IPC(8): C07C227/08C07C227/42C07C229/08C01C1/16
CPCC01C1/164C07C227/08C07C227/42C07C229/08Y02P20/584
Inventor 吴狄峰李舟王文王长江高杉卢刚
Owner SICHUAN FOURSTAR BIOTECH RANDD CORP
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