Gradient hyaluronic acid dressing and preparation method thereof

A technology of hyaluronic acid and oligomeric hyaluronic acid, which is applied in medical science, absorbent pads, bandages, etc., can solve problems that do not involve the prevention and reduction of scars, affect the appearance, and severe itching, and achieve prevention and scar formation, Reduces scar formation and promotes healing effects

Inactive Publication Date: 2018-09-28
广州芬森医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The above inventions and their dressing products mainly focus on protecting the wound environment, promoting wound healing, and preventing wound infection. Although they have played a good role in wound treatment, th

Method used

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  • Gradient hyaluronic acid dressing and preparation method thereof

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preparation example Construction

[0069] The preparation method of this gradient hyaluronic acid dressing comprises the following steps:

[0070] 1) Pack the base material into the packaging material, sterilize, and set aside;

[0071] 2) Mix high-molecular-weight hyaluronic acid, medium-molecular-weight hyaluronic acid, low-molecular-weight hyaluronic acid, oligomeric hyaluronic acid and water, stir and dissolve to obtain liquid A;

[0072] 3) Mix EGF, KGF, FGF, glycerin and water, and stir evenly to obtain liquid B;

[0073] 4) Mix hydroxyethyl cellulose, collagen, alginate, chitosan, phenoxyethanol, plant extracts and water, and stir evenly to obtain liquid C;

[0074] 5) mixing liquid A, liquid B and liquid C to obtain a dressing agent;

[0075] 6) Fill the dressing agent into the packaging material obtained in step 1) and fully infiltrate it to obtain a gradient hyaluronic acid dressing.

[0076] Preferably, in step 2) of the preparation method, the total content of hyaluronic acid in liquid A is 0.1 w...

Embodiment 1

[0081] The preparation method of embodiment 1 gradient hyaluronic acid dressing, comprises the following steps:

[0082] 1) Fold the non-woven fabric into an aluminum foil bag, sterilize it, and set it aside;

[0083] 2) Take 50 grams of hyaluronic acid (including: 25 grams of high molecular weight hyaluronic acid, 5 grams of medium molecular weight hyaluronic acid, 15 grams of low molecular weight hyaluronic acid, and 5 grams of oligomeric hyaluronic acid), add 1000 mL of ultrapure water , heated and stirred to dissolve to obtain liquid A;

[0084] 3) Mix 0.5gEGF, 0.25gKGF, 0.25gFGF, 100g glycerin and 1000mL ultrapure water, and stir evenly to obtain liquid B;

[0085] 4) 20g hydroxyethyl cellulose, 10g sodium alginate, 15g chitosan, 20g phenoxyethanol, 5g witch hazel extract, 20g scutellaria root extract, 10g raspberry extract, 5g Burnet extract, Mix 10g of onion extract with 8000mL of ultrapure water, and stir evenly to obtain liquid C;

[0086] 5) mixing liquid A, liqui...

Embodiment 2

[0089] The preparation method of embodiment 2 gradient hyaluronic acid dressing, comprises the following steps:

[0090] 1) Fold the non-woven fabric into an aluminum foil bag, sterilize it, and set it aside;

[0091] 2) Take 50 grams of hyaluronic acid (including: 25 grams of high molecular weight hyaluronic acid, 5 grams of medium molecular weight hyaluronic acid, 15 grams of low molecular weight hyaluronic acid, and 5 grams of oligomeric hyaluronic acid), add 1000 mL of ultrapure water , heated and stirred to dissolve to obtain liquid A;

[0092] 3) Mix 0.5gEGF, 0.25gKGF, 100g glycerin and 1000mL ultrapure water, and stir evenly to obtain liquid B;

[0093] 4) 20g hydroxyethyl cellulose, 10g sodium alginate, 10g collagen, 15g chitosan, 20g phenoxyethanol, 5g witch hazel extract, 20g scutellaria baicalensis root extract, 10g raspberry extract, 5g ground Mix elm extract, 10g onion extract and 8000mL ultrapure water, and stir evenly to obtain liquid C;

[0094] 5) mixing li...

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Abstract

The invention discloses a gradient hyaluronic acid dressing and a preparation method thereof. The gradient hyaluronic acid dressing contains a packing material, a base material and a dressing medicament, wherein the dressing medicament is prepared from the following raw materials: high-molecular-weight hyaluronic acid, medium-molecular-weight hyaluronic acid, low-molecular-weight hyaluronic acid,oligomeric hyaluronic acid, EGF, KGF, FGF, glycerin, hydroxyethyl cellulose, collagen, alginate, chitosan, phenoxyethanol, plant extract and water. The invention also discloses a preparation method ofthe gradient hyaluronic acid dressing. The scar-preventing repair dressing made by adopting the gradient hyaluronic acid has the remarkable effects of promoting healing and preventing and reducing scar formation on skin injuries and can be used for treatment and nursing of various body surface injuries and problematic skin.

Description

technical field [0001] The invention relates to a gradient hyaluronic acid dressing and a preparation method thereof. Background technique [0002] The repair of human skin damage is a complex physiological process. The speed of wound healing and the formation and proliferation of scars after healing have always been difficult problems for people. For this reason, people are trying to find ideal dressings, including good biocompatibility, control and absorption of wound exudate, preventing bacterial invasion and inhibiting bacterial growth and reproduction, protecting new tissues, accelerating wound healing, preventing and reducing scars , hemostatic analgesia, good mechanical properties, etc. But also do not have a kind of dressing can reach and satisfy above-mentioned requirement so far. [0003] With the development of molecular biology, the research on the application of biomaterials in medical dressings is increasing, and a lot of results have been obtained, such as c...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/32A61L15/44
CPCA61L15/28A61L15/32A61L15/325A61L15/44A61L2300/30A61L2300/412A61L2300/414C08L5/08C08L1/284C08L89/00
Inventor 沈静飞
Owner 广州芬森医学科技有限公司
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