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A kind of centrifugal vaccine production method

A vaccine production, centrifugal technology, applied in centrifuges and other directions, can solve problems such as many limitations, damage to vaccines, and damage to vaccine structure, and achieve the effects of stable production sequence, increased survival rate, and improved survival efficiency.

Active Publication Date: 2019-11-01
YIXING HUADING FOOD MACHINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the field of vaccine production, the vaccine and the culture medium can be separated by physical separation through centrifugal movement. However, due to the complexity of the vaccine cultivation process and many limitations, it is not possible to simply separate directly, otherwise the structure of the vaccine will be destroyed and the vaccine will be damaged.

Method used

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  • A kind of centrifugal vaccine production method
  • A kind of centrifugal vaccine production method
  • A kind of centrifugal vaccine production method

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Embodiment Construction

[0023] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0024] Such as figure 1 , figure 2 and image 3 As shown, the present invention is divided into several stages of pre-rinsing, intermediate rinsing, post-rinsing, disinfection, vaccine separation and post-treatment, wherein the pre-rinsing, intermediate rinsing and post-rinsing are carried out respectively before and after the disinfection and vaccine separation stages; Each of the stages operates in an orderly manner on liquids with different components, such as stock solution and pure water.

[0025] First, open the pure water inlet valve to realize the pre-cleaning of the whole machine, and replace the remaining materials with hot water with a flow rate of 5m³ / h. The flushing time is 2-5min, and wait until the temperature in the pipe and cavity of the whole machine reaches 70 At -80°C, close the pure water valve, open the alkali valve channel, co...

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Abstract

The invention relates to a centrifugal vaccine production method. The method comprises pre-flushing, intermediate flushing, post-flushing, disinfecting, vaccine separation and aftertreatment. Pre-flushing comprises a heat water replacement material stage and a corrosion substance flushing stage, the adopted temperature is above 80 DEG C, hot water flushing with the liquid inlet flow being 5m<3> / his adopted, the operation continues for 5 min, the rotating speed of a centrifugal machine is larger than 500 rpm, the chloride-free sodium hydroxide solution with the concentration being 2% is addedinto hot water, the liquid inlet flow is kept being 5m<3> / h, and the operation continues for 20 min. Through the physical method, effective separation of vaccine and a nutrient solution is achieved, the vaccine survival rate is improved, and it is ensured that the production sequence of the vaccine is stable.

Description

technical field [0001] The invention belongs to the field of centrifugal separation of vaccines, and in particular relates to a centrifugal vaccine production method. Background technique [0002] The centrifuge uses high-speed rotation to generate centrifugal force to separate a variety of incompatible materials with different densities. In the field of vaccine production, the vaccine and the culture medium can be separated by physical separation through centrifugal movement. However, due to the complexity of the vaccine cultivation process and many limitations, it is not possible to simply separate directly, otherwise the structure of the vaccine will be destroyed and the vaccine will be damaged. Contents of the invention [0003] Purpose of the invention: The purpose of the present invention is to overcome the deficiencies in the prior art and provide a centrifugal vaccine production method that realizes the effective separation of vaccine and culture medium through phy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B04B15/02
CPCB04B15/02
Inventor 徐彬朱忠伟陈强邱超云
Owner YIXING HUADING FOOD MACHINE CO LTD
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