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A kind of supramolecular hydrogel and preparation method thereof

A technology of supramolecular hydrogel and anhydrous potassium carbonate is applied in the field of biomedical material preparation, which can solve the problems of insufficient mechanical strength of supramolecular hydrogel, and achieve the effects of strong molecular recognition ability, simple method and improved mechanical strength.

Inactive Publication Date: 2019-07-09
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In view of the above-mentioned deficiencies in the prior art, the present invention provides a supramolecular hydrogel and its preparation method, which can effectively solve the problem of insufficient mechanical strength of the existing supramolecular hydrogel

Method used

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  • A kind of supramolecular hydrogel and preparation method thereof
  • A kind of supramolecular hydrogel and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0029] A preparation method of supramolecular hydrogel, comprising the following steps:

[0030] (1) Preparation of 4-arm-PEG-BPY 2+

[0031] a. Dissolve 1 g of four-arm PEG (4-arm-PEG, Mn=20000 g / mol) and 5 g of anhydrous potassium carbonate in 30 mL of dichloromethane at room temperature, and then in an ice-water bath with 100 ~ Magnetic stirring at a speed of 200r / min for 40min;

[0032] b. Add 0.1 g of bromoacetyl bromide to the product obtained in step a, seal it, take out the ice pack, and stir magnetically at a speed of 100 to 200 r / min for 24 hours at room temperature;

[0033] c. Centrifuge the product obtained in step b at 3500r / min. After centrifugation for 10min, collect the supernatant, add excess anhydrous ether for precipitation, then filter, and freeze-dry the filter cake at -80°C to obtain 4-arm-PEG-Br;

[0034] d. Add 1 mol of 4-arm-PEG-Br and 1 mol of 4,4'-bipyridine to 30 mL of anhydrous acetonitrile at the same time, heat and reflux at 80°C for 24 hour...

Embodiment 2

[0042] A preparation method of supramolecular hydrogel, comprising the following steps:

[0043] (1) Preparation of 4-arm-PEG-BPY 2+

[0044] a. Dissolve 1 g of four-arm PEG (4-arm-PEG, Mn=20000 g / mol) and 7 g of anhydrous potassium carbonate in 30 mL of dichloromethane at room temperature, and then in an ice-water bath with 100 ~ Magnetic stirring at a speed of 200r / min for 40min;

[0045]b. Add 0.1 g of bromoacetyl bromide to the product obtained in step a, seal it, take out the ice pack, and stir magnetically at a speed of 100 to 200 r / min for 24 hours at room temperature;

[0046] c. Centrifuge the product obtained in step b at 3500r / min. After centrifugation for 10min, collect the supernatant, add excess anhydrous ether for precipitation, then filter, and freeze-dry the filter cake at -80°C to obtain 4-arm-PEG-Br;

[0047] d. Add 1 mol of 4-arm-PEG-Br and 1.1 mol of 4,4'-bipyridine to 30 mL of anhydrous acetonitrile at the same time, heat and reflux at 80°C for 24 hou...

Embodiment 3

[0055] A preparation method of supramolecular hydrogel, comprising the following steps:

[0056] (1) Preparation of 4-arm-PEG-BPY 2+

[0057] a. Dissolve 1 g of four-arm PEG (4-arm-PEG, Mn=20000 g / mol) and 10 g of anhydrous potassium carbonate in 30 mL of dichloromethane at room temperature, and then in an ice-water bath with 100 ~ Magnetic stirring at a speed of 200r / min for 40min;

[0058] b. Add 0.1 g of bromoacetyl bromide to the product obtained in step a, seal it, take out the ice pack, and stir magnetically at a speed of 100 to 200 r / min for 24 hours at room temperature;

[0059] c. Centrifuge the product obtained in step b at 3500r / min. After centrifugation for 10min, collect the supernatant, add excess anhydrous ether for precipitation, then filter, and freeze-dry the filter cake at -80°C to obtain 4-arm-PEG-Br;

[0060] d. Add 1 mol of 4-arm-PEG-Br and 1.1 mol of 4,4'-bipyridine to 30 mL of anhydrous acetonitrile at the same time, heat and reflux at 80°C for 24 h...

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Abstract

The invention discloses a supramolecular hydrogel and a preparation method thereof. Its preparation method comprises the following steps: (1) with 4-arm-PEG-BPY 2+ Mix with cucurbituril [8], dissolve in water, and prepare 4‑arm‑PEG‑BPY 2+ (2) preparing a 4-arm-PEG-Pyr solution with a concentration of 1-5 wt%, and stirring and mixing with the mixed solution obtained in step (1) to obtain a supramolecular hydrogel ; among them, BPY 2+ , Pyr and cucurbituril [8] molar ratio is 0.5~1:1~2:0.3~1.5. The supramolecular hydrogel prepared by the method of the invention has an ideal uniform network structure and high mechanical strength.

Description

technical field [0001] The invention belongs to the technical field of preparation of biomedical materials, and in particular relates to a supramolecular hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a kind of gel material that uses water as the dispersion medium. It is formed by cross-linking one or more hydrophilic polymers through covalent or non-covalent bonds. It has a superior three-dimensional network structure and is stable. The three-dimensional spatial structure of the hydrogel allows the hydrogel to retain water without structural change, thus, the hydrogel has good permeability and biocompatibility; however, the general physical cross-linked supramolecular hydrogel often has relatively poor Low mechanical properties, and the mechanical properties of supramolecular hydrogels based on host-guest interactions reported so far are also at a low level, which cannot meet the needs. Contents of the invention [0003] In view of t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L71/02C08J3/075C08J3/24C08G65/332C08G65/333C08G65/337
CPCC08G65/3326C08G65/333C08G65/33337C08G65/337C08G2650/04C08G2650/20C08G2650/50C08J3/075C08J3/246C08J2371/02C08J2471/02
Inventor 汪建新王莹莹陈太军翁杰冯波鲁雄周绍兵屈树新智伟
Owner SOUTHWEST JIAOTONG UNIV