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A kind of preparation method of porous fiber composite hemostatic material

A hemostatic material, porous fiber technology, applied in pharmaceutical formulations, surgical adhesives, surgery, etc., can solve the problems of insufficient water absorption, slow water absorption, low water absorption ratio, etc., to increase the healing speed, increase stability, The effect of increasing tissue nutrition

Active Publication Date: 2021-07-06
INST OF APPLIED CHEM JIANGXI ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the overall water absorption of the hemostatic material is not strong enough, the water absorption multiple is low, and the water absorption speed is slow, especially for active bleeding.

Method used

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  • A kind of preparation method of porous fiber composite hemostatic material

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The preparation method of the porous fiber composite hemostatic material in this embodiment is mainly composed of modified zeolite and modified starch loaded on the modified zeolite, including the following steps:

[0034] (1) Preparation of modified zeolite: after natural zeolite is purified, alkalized, and then subjected to thermal activation treatment, modified zeolite is obtained;

[0035] (2) Preparation of modified starch: the original starch is firstly produced through a pregelatinization process, then undergoes denaturation treatment, and then undergoes agglomeration, pelletizing, and sieving to obtain modified starch;

[0036] (3) The modified zeolite in step (1) is dropped into a 5% hydroxyethyl cellulose solution, stirred, then centrifuged to separate the modified zeolite from the hydroxyethyl cellulose solution, and finally dried;

[0037] (4) Get the modified zeolite of step (3) drying treatment and the modified starch obtained in step (2), add the modified...

Embodiment 2

[0048] The preparation method of the porous fiber composite hemostatic material in this embodiment is mainly composed of modified zeolite and modified starch loaded on the modified zeolite, including the following steps:

[0049] (1) Preparation of modified zeolite: after natural zeolite is purified, alkalized, and then subjected to thermal activation treatment, modified zeolite is obtained;

[0050] (2) Preparation of modified starch: the original starch is firstly produced through a pregelatinization process, then undergoes denaturation treatment, and then undergoes agglomeration, pelletizing, and sieving to obtain modified starch;

[0051] (3) The modified zeolite in step (1) is dropped into a 5% hydroxyethyl cellulose solution, stirred, then centrifuged to separate the modified zeolite from the hydroxyethyl cellulose solution, and finally dried;

[0052] (4) Get the modified zeolite of step (3) drying treatment and the modified starch obtained in step (2), add the modified...

Embodiment 3

[0063] The preparation method of the porous fiber composite hemostatic material in this embodiment is composed of modified zeolite and modified starch loaded on the modified zeolite, including the following steps:

[0064] (1) Preparation of modified zeolite: after natural zeolite is purified, alkalized, and then subjected to thermal activation treatment, modified zeolite is obtained;

[0065] (2) Preparation of modified starch: the original starch is firstly produced through a pregelatinization process, then undergoes denaturation treatment, and then undergoes agglomeration, pelletizing, and sieving to obtain modified starch;

[0066] (3) The modified zeolite in step (1) is dropped into a 5% hydroxyethyl cellulose solution, stirred, then centrifuged to separate the modified zeolite from the hydroxyethyl cellulose solution, and finally dried;

[0067] (4) Get the modified zeolite of step (3) drying treatment and the modified starch obtained in step (2), add the modified zeolit...

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Abstract

The invention discloses a method for preparing a porous fiber composite hemostatic material. The hemostatic material is mainly composed of modified zeolite and modified starch loaded on the modified zeolite, including the following steps: (1) Preparation of the modified zeolite; ( 2) Preparation of modified starch; (3) Put the modified zeolite in step (1) into the hydroxyethyl cellulose solution with a concentration of 5%, stir, and then perform centrifugation to separate the modified zeolite from the hydroxyethyl cellulose solution , and finally perform drying treatment; (4) take the modified zeolite dried in step (3) and the modified starch obtained in step (2), add the modified zeolite to the acetic acid solution of the modified starch, and spray dry after sufficient stirring. Pass through a 100-mesh sieve, pack under aseptic conditions, and sterilize to obtain the porous fiber composite hemostatic material. The hemostatic material prepared by the method of the invention can be directly used on bloody wounds, has rapid hemostasis, good hemostatic effect, and has a viscous sealing effect.

Description

technical field [0001] The invention relates to the technical field of hemostatic materials, in particular to a preparation method of a porous fiber composite hemostatic material. Background technique [0002] Hemostasis is an important part of surgery, especially first aid for war wounds and trauma. The normal hemostasis mechanism mainly includes three aspects: the contraction of small blood vessels, the activation of platelets and the activation of the coagulation system. Among them, the contraction of small blood vessels is the earliest response to hemostasis after trauma. After the blood vessels are damaged, the smooth muscles of the blood vessels constrict the blood vessels and slow down the blood flow through axon reflex, which is beneficial to blood coagulation and hemostasis. Platelets have the physiological function of adhering to the surface of wounds and foreign bodies, and play an important role in the initial stage of hemostasis. The activation of adhered plat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/02A61L24/08A61L24/00
CPCA61L24/001A61L24/0015A61L24/0042A61L24/02A61L24/08A61L2400/04C08L3/04C08L1/284
Inventor 张鹏孙复钱黄日明舒泉水
Owner INST OF APPLIED CHEM JIANGXI ACAD OF SCI