Tartrate salt of selective cdk9 inhibitor and its crystal form
A technology of tartrate salt and crystal form, which is applied in the field of chemical pharmacy, can solve the problems of unsalted species, further evaluation of performance, and unprepared, etc., and achieve good crystallinity, easy production scale expansion, and good stability. Effect
Active Publication Date: 2020-03-20
CHANGZHOU QIANHONG BIOPHARMA +1
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Abstract
The invention relates to the technical field of chemical pharmacy, and discloses a compound of 3-(5-fluoro-4-(4-methyl-2-(methylamino)thiazol-5-yl)pyrimidin-2-ylamino)-benzenesulfonamide Tartrate and its polymorphs, which are inhibitors of protein kinases, especially cyclin-dependent kinase 9 (CDK9), are useful in the treatment of proliferative disorders such as cancer and other diseases in which protein kinase/CDK activity is implicated.
Application Domain
Organic active ingredientsOrganic chemistry methods +1
Technology Topic
Selective inhibitionPyrimidine +13
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